Randall King, Winnipeg Free Press
"Soderbergh, working from a script by Scott Z. Burns, delivers a genre mash-up, a murder mystery that strives to address the social ills that attend prescription pharmaceuticals. This has the capacity to be a hot-button movie playing on the all-too-pertinent link between violence and prescription meds. But Soderbergh seems to be gingerly avoiding head-on confrontation. Instead, he bottles a more mundane thriller of the type that might have appealed to Brian De Palma a decade or two earlier."

Jeff Myers, Metro Times
"From Soderbergh’s head-scratching opening homage to Roman Polanski’s Rosemary’s Baby to a plot that, at first, seems to be a cautionary legal tale of big pharma abuses, Side Effects unexpectedly develops into a postmodern Hitchcockian thriller —which is actually akin to one of Brian De Palma’s chilly psychological puzzles. That’s an awful lot of cinematic referencing for one movie. But let me put a cherry on top, won’t you? With its eventual double-cross plot turns, paranoid wrong-man drama, and corrupt corporate subtext, Side Effects plays like a particularly nasty episode of Law and Order: Criminal Intent had it been directed by Robert Altman."

Josh Board, Fox 5 San Diego
"Now, this is about all I will tell you regarding the plot. Even the trailers, and the stars of the movie on talk shows, have given away too much. I went in knowing nothing about it when I saw it last month. And I loved the way it went from a bit of an ethical dilemma to a psychological thriller. It was Hitchcock-light. More like Brian De Palma."

Al Alexander, The Patriot Ledger
"To even begin to describe the plot would be a disservice to anyone who has not yet basked in the film’s psychotic pleasures. Just know that nothing – and I mean, nothing – is what it seems, right up to the superbly composed final shots that come courtesy of Soderbergh, who serves as both editor and cinematographer (under the pseudonym of Peter Andrews) as well as director. It’s easily his finest – and most commercial – effort since Oceans 13. It’s also like nothing he’s ever done before, as he boldly treads into the domain normally reserved for masters of suspense like Hitchcock (think Vertigo) and Brian De Palma (Body Double, anyone?)."

Kurt Loder, Reason.com
"Steven Soderbergh’s Side Effects is a grippingly 'Hitchcockian' movie, but not in the manner of, say, Brian De Palma, who blithely appropriated the master’s narrative elements and visual techniques for ’80s films like Dressed to Kill and Body Double. Soderbergh’s picture is something else, a bracingly lurid tale of a man trapped in a thickening web of circumstance—the sort of story that Hitchcock might well have wanted to tell himself. In the late director’s absence, Soderbergh, who over the course of 24 years has demonstrated a rare facility in a wide array of genres, proves to be just the man for the job."

Brian Tallerico, Hollywood Chicago
"Side Effects not only draws on Soderbergh’s career but has conscious echoes of Roman Polanski, Brian De Palma, and Alfred Hitchcock as well...

"That first act has echoes of Polanski’s wonderful, urban paranoia films like Repulsion as Soderbergh (under the pseudonym of Peter Andrews) shoots the 'wounded bird' of Mara often from below or above, heightening the claustrophobia of a city in which millions can feel alone despite being in such close proximity. Then the film twists and Soderbergh/Andrews & Burns bring a different, pulpier style that’s more reminiscent of De Palma when he so blatantly mimicked Hitchcock. Technically, it’s a marvelous piece of work as Soderbergh proves defter with his camera with every film."

Kate Erbland, Film School Rejects
"Yet, Side Effects seems more intent on toying with its viewers’ expectations than in really crafting its own internal cat-and-mouse game. The actual meat of its full storyline is unexpectedly trashy and tawdry, like some unholy mix of Brian De Palma film and Lifetime Original movie."