An ancient flower called Nicodemus was resurrected by Dr. Hamilton, Lex Luthor's meteor rock researcher. Unfortunately, these flowers are found to be very dangerous to humans when sprayed with it's pollens. One of the Nicodemus flower from Dr. Hamilton's lab was stollen and he got himself infected and made him act wild and unsure about himself.

Jonathan Kent got sprayed by the flower too. So as Lana Lang and Pete Ross. They all turned into a very wild people. Jonathan starts acting like a bad boy, Lana broke up with Whitney and puts the move on Clark. Pete almost killed Lex for taking away his friendship with Clark. After all this chaos, They all ended up in a deadly coma. Clark and Chloe must find the mystery behind these flowers before it's too late. Luckily, Dr. Hamilton discovered an antidote and saves everybody from their deadly coma.