Location and Function:
- found in the membrane of the sarcoplasmic reticulum (SR) of skeletal muscle
- located at the junction face of the terminus of the cisternae
- [diagram]
- hydrophobic part located in the membrane of the SR
- triad junction of 2 terminal cisternae surrounding 1 transverse tubule (T-tubule)
- large hydrophilic part bridges gap between SR and T-tubule
- the T-tubule carries the action potential to the
dihydropyrdine receptor (DHPR)
- theory that the DHPR has direct interaction with the ryanodine receptor (RYR1)
- interaction causes RYR1 to release Ca2+
- the released Ca2+ binds with troponin in the thin filament which initiates muscle contraction
- [diagram]
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