SR 272 begins at Jct US 195 in Colfax and heads east via Palouse to the Washington-Idaho state line. At the state line, Washington SR 272 ends and Idaho SR 6 begins. SR 270 and SR 27 share the same roadway for a few blocks in Palouse. SR 272 is 19.22 miles long.
Before 1964, SR 272 had been SSH 3F from Colfax to Palouse and part of an unnamed branch of PSH 3 from Palouse to the Idaho state line.
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