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Section 1
To Meriwether Lewis, Jefferson wrote:
"Washington, April 27, 1803.
"Dear Sir,--Yours of the 20th from Lancaster was received the night before last. Not having heard from you since the time of my leaving Washington I had written to you on the 23d and lodged it in Philadelphia. You will therefore probably receive that & this together. I inclose you a copy of the rough draft of instructions I have prepared for you, that you may have time to consider them, &c to propose any modifications which may occur to yourself as useful. Your destination being known to Mr. Patterson, Doctrs Wistar, Rush & Barton, these instructions may be submitted to their perusal. A considerable portion of them being within the field of the Philosophical society, which once undertook the same mission, I think it my duty to consult some of its members limiting the communication by the necessity of secrecy in a good degree. These gentlemen will suggest any additions they will think useful, as has been before asked of them. We have received information that Connor cultivates in the first degree the patronage of the British government; to which he values ours as only secondary. As it is possible however that his passion for the expedition may overrule that for the British, and as I do not see that the British agents will necessarily be disposed to counteract us, I think Connor's qualifications make it desirable to engage him, and that the communication to him will be as useful, as it was certainly proper under our former impression of him. The idea that you are going to explore the Mississippi has been generally given out. It satisfies public curiosity, and masks sufficiently the real destination. I shall be glad to hear from you, as soon after your arrival at Philadelphia as you can form an idea when you will leave, and when be here. Accept assurances of my constant & sincere affection."
 

Section 2
" Instructions to Lewis.
"To Merryweather Lewis, Esq., Captain of the 1st Regiment of Infantry of the United States of America.
"Your situation as Secretary of the President of the United States has made you acquainted with the objects of my confidential message of Jan. 18, 1803, to the legislature. You have seen the act they passed, which, tho' expressed in general terms, was meant to sanction those objects, and you are appointed to carry them into execution.
"Instruments for ascertaining by celestial observations the geography of the country thro' which you will pass, have been already provided. Light articles for barter, & presents among the Indians, arms for your attendants, say for from 10 to 12 men, boats, tents, & other travelling apparatus, with ammunition, medicine, surgical instruments & provision you will have prepared with such aids as the Secretary at War can yield in his department; & from him also you will receive authority to engage among our troops, by voluntary agreement, the number of attendants above mentioned, over whom you, as their commanding officer are invested with all the powers the laws give in such a case.

Section 3
"As your movements while within the limits of the U. S. will be better directed by occasional communications, adapted to circumstances as they arise, they will not be noticed here. What follows will respect your proceedings after your departure from the U. S.
"Your mission has been communicated to the Ministers here from France, Spain, & Great Britain, and through them to their governments: and such assurances given them as to it's objects as we trust will satisfy them. The country of Louisiana having been ceded by Spain to France, the passport you have from the Minister of France, the representative of the present sovereign of the country, will be a protection with all it's subjects: And that from the Minister of England will entitle you to the friendly aid of any traders of that allegiance with whom you may happen to meet.

Section 4
"The object of your mission is to explore the Missouri river, & such principal stream of it, as, by it's course & communication with the water of the Pacific Ocean may offer the most direct & practicable water communication across this continent, for the purposes of commerce.
"Beginning at the mouth of the Missouri, you will take observations of latitude and longitude at all remarkable points on the river, & especially at the mouths of rivers, at rapids, at islands & other places & objects distinguished by such natural marks & characters of a durable kind, as that they may with certainty be recognized hereafter. The courses of the river between these points of observation may be supplied by the compass, the log-line & by time, corrected by the observations themselves. The variations of the compass too, in different places should be noticed.
"The interesting points of the portage between the heads of the Missouri & the water offering the best communication with the Pacific Ocean should be fixed by observation & the course of that water to the ocean, in the same manner as that of the Missouri.

Section 5
"Your observations are to be taken with great pains & accuracy to be entered distinctly, & intelligibly for others as well as yourself, to comprehend all the elements necessary, with the aid of the usual tables to fix the latitude & longitude of the places at which they were taken, & are to be rendered to the war office, for the purpose of having the calculations made concurrently by proper persons within the U. S. Several copies of these as well as of your other notes, should be made at leisure times & put into the care of the most trustworthy of your attendants, to guard by multiplying them against the accidental losses to which they will be exposed. A further guard would be that one of these copies be written on the paper of the birch, as less liable to injury from damp than common paper.

Section 6
"The commerce which may be carried on with the people inhabiting the line you will pursue, renders a knolege of these people important. You will therefore endeavor to make yourself acquainted, as far as a diligent pursuit of your journey shall admit,

• with the names of the nations & their numbers;
• the extent & limits of their possessions:
• their relations with other tribes or nations;
• their language, traditions, monuments;
• their ordinary occupations in agriculture, fishing, hunting, war, arts, & the implements for these;
• their food, clothing, & domestic accommodations;
• the diseases prevalent among them, & the remedies they use;
• moral and physical circumstance which distinguish them from the tribes they know;
• peculiarities in their laws, customs & dispositions;
• and articles of commerce they may need or furnish & to what extent.

Section 7
"And considering the interest which every nation has in extending & strengthening the authority of reason & justice among the people around them, it will be useful to acquire what knolege you can of the state of morality, religion & information among them, as it may better enable those who endeavor to civilize & instruct them, to adapt their measures to the existing notions & practises of those on whom they are to operate.
"Other objects worthy of notice will be

• the soil & face of the country, its growth & vegetable productions especially those not of the U. S.
• the animals of the country generally, & especially those not known in the U. S.
• The remains & accounts of any which may be deemed rare or extinct;
• the mineral productions of every kind; but more particularly metals, limestone, pit coal & saltpetre; salines & mineral waters, noting the temperature of the last & such circumstances as may indicate their character; volcanic appearances; climate as characterized by the thermometer, by the proportion of rainy, cloudy & clear days, by lightening, hail, snow, ice, by the access & recess of frost, by the winds, prevailing at different seasons, the dates at which particular plants put forth or lose their flowers, or leaf, times of appearance of particular birds, reptiles or insects.

Section 8
"Altho' your route will be along the channel of the Missouri, yet you will endeavor to inform yourself by inquiry, of the character and extent of the country watered by its branches, and especially on it's southern side. The north river or Rio Bravo which runs into the gulph of Mexico, and the north river, or Rio colorado, which runs into the gulph of California, are understood to be the principal streams heading opposite to the waters of the Missouri, & running Southwardly. Whether the dividing grounds between the Missouri & them are mountains or flatlands, what are their distance from the Missouri, the character of the intermediate country, & the people inhabiting it, are worthy of particular enquiry. The northern waters of the Missouri are less to be enquired after, because they have been ascertained to a considerable degree, and are still in a course of ascertainment by English traders & travellers. But if you can learn anything certain of the most northern source of the Mississippi, & of it's position relative to the lake of the woods, it will be interesting to us. Some account too of the path of the Canadian traders from the Mississippi, at the mouth of the Ouisconsin river, to where it strikes the Missouri and of the soil and rivers in it's course, is desirable.

Section 9
"In all your intercourse with the natives treat them in the most friendly & conciliatory manner which their own conduct will admit; allay all jealousies as to the object of your journey, satisfy them of it's innocence, make them acquainted with the position, extent, character, peaceable & commercial dispositions of the U. S., of our wish to be neighborly, friendly & useful to them, & of our dispositions to a commercial intercourse with them; confer with them on the points most convenient as mutual emporiums, & the articles of most desirable interchange for them & us. If a few of their influential chiefs, within practicable distance, wish to visit us, arrange such a visit with them, and furnish them with authority to call on our officers, on their entering the U. S. to have them conveyed to this place at the public expense. If any of them should wish to have some of their young people brought up with us, & taught such arts as may be useful to them, we will receive, instruct & take care of them. Such a mission, whether of influential chiefs, or of young people, would give some security to your own party. Carry with you some matter of the kine-pox, inform those of them with whom you may be of it's efficacy as a preservative from the small-pox; and instruct & encourage them in the use of it. This may be especially done wherever you may winter.

Section 10
"As it is impossible for us to foresee in what manner you will be received by those people, whether with hospitality or hostility, so is it impossible to prescribe the exact degree of perseverance with which you are to pursue your journey. We value too much the lives of citizens to offer them to probably destruction. Your numbers will be sufficient to secure you against the unauthorized opposition of individuals, or of small parties: but if a superior force, authorized or not authorized, by a nation, should be arrayed against your further passage, & inflexibly determined to arrest it, you must decline it's further pursuit, & return. In the loss of yourselves, we should lose also the information you will have acquired. By returning safely with that, you may enable us to renew the essay with better calculated means. To your own discretion therefore must be left the degree of danger you may risk, & the point at which you should decline, only saying we wish you to err on the side of your safety, & to bring back your party safe, even if it be with less information.

Section 11
"As far up the Missouri as the white settlements extend, an intercourse will probably be found to exist between them and the Spanish posts at St. Louis, opposite Cahokia, or Ste. Genevieve opposite Kaskaskia. From still farther up the river, the traders may furnish a conveyance for letters. Beyond that you may perhaps be able to engage Indians to bring letters for the government to Cahokia or Kaskaskia on promising that they shall there receive such special compensation as you shall have stipulated with them. Avail yourself of these means to communicate to us at seasonable intervals a copy of your journal, notes & observations of every kind, putting into cipher whatever might do injury if betrayed.

Secton 12
"Should you reach the Pacific Ocean inform yourself of the circumstances which may decide whether the furs of those parts may not be collected as advantageously at the head of the Missouri (convenient as is supposed to the waters of the Colorado & Oregon or Columbia) as at Nootka Sound or any other point of that coast; & that trade be consequently conducted through the Missouri & U. S. more beneficially than by the circumnavigation now practised.
"On your arrival on that coast endeavor to learn if there be any port within your reach frequented by the sea-vessels of any nation, and to send two of your trusted people back by sea, in such way as shall appear practicable, with a copy of your notes. And should you be of opinion that the return of your party by the way they went will be eminently dangerous, then ship the whole, & return by sea by way of Cape Horn or the Cape of Good Hope, as you shall be able. As you will be without money, clothes or provisions, you must endeavor to use the credit of the U. S. to obtain them; for which purpose open letters of credit shall be furnished you authorizing you to draw on the Executive of the U. S. or any of its officers in any part of the world, in which drafts can be disposed of, and to apply with our recommendations to the consuls, agents, merchants or citizens of any nation with which we have intercourse, assuring them in our name that any aids they may furnish you, shall be honorably repaid and on demand. Our consuls Thomas Howes at Batavia in Java, William Buchanan of the Isles of France and Bourbon & John Elmslie at the Cape of Good Hope will be able to supply your necessities by drafts on us.

Secton 13
"Should you find it safe to return by the way you go, after sending two of your party round by sea, or with your whole party, if no conveyance by sea can be found, do so; making such observations on your return as may serve to supply, correct or confirm those made on your outward journey.
"In re-entering the U. S. and reaching a place of safety, discharge any of your attendants who may desire & deserve it: procuring for them immediate paiment of all arrears of pay & cloathing which may have incurred since their departure & assure them that they shall be recommended to the liberality of the Legislature for the grant of a souldier's portion of land each, as proposed in my message to Congress: & repair yourself with your papers to the seat of government.
"To provide, on the accident of your death, against anarchy, dispersion & the consequent danger to your party, and total failure of the enterprise, you are hereby authorized by an instrument signed & written in your own hand to name the person among them who shall succeed to the command on your decease, & by like instruments to change the nomination from time to time, as further experience of the characters accompanying you shall point out superior fitness: and all the powers & authorities given to yourself are, in the event of your death transferred to & vested in the successor so named, with further power to him, & his successors in like manner to name each his successor, who, on the death of his predecessor shall be invested with all the powers & authorities given to yourself.
"Given under my hand at the city of Washington, this 20th day of June, 1803."