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To Casper Wistar, Jefferson wrote:
"Washington, Feb. 28, 1803.
"Dear Sir,--The enclosed sheets may contain some details which perhaps may be thought interesting enough for the transactions of our society. They were forwarded to me by Mr. Dunbar with a couple of vocabularies which I retain to be added to my collection.
"What follows is to be perfectly confidential. I have at length succeeded in procuring an essay to be made of exploring the Missouri & whatever river heading with that, runs into the western Ocean. Congress by a secret authority enables me to do it. A party of about 10. chosen men headed by an officer will immediately set out. We cannot in the U. S. find a person who to courage, prudence, habits & health adapted to the woods, & some familiarity with the Indian character, joins a perfect knowledge of botany, natural history, mineralogy & astronomy, all of which would be desirable. To the first qualifications Captain Lewis my secretary adds a great mass of accurate observation made on the different subjects of the three kingdoms as existing in these states, not under their scientific forms, but so as that he will readily seize whatever is new in the country he passes thro' and give us accounts of new things only; and he has qualified himself for fixing the longitude & latitude of the different points in the line he will go over. I have thought it would be useful to confine his attention to those objects only on which information is most deficient & most desirable: & therefore would thank you to make a note on paper of those which occur to you as most desirable for him to attend to. He will be in Philadelphia within two or three weeks & will call on you. Any advice or hints you can give him will be thankfully received & usefully applied. I presume he will compleate his tour there & back in two seasons. Accept assurances of my sincere esteem & high respect."

The original document can be viewed on the Library of Congress website.  It also contains a link to the entire transcription.