Pennsylvania State Route 221 is a north-south highway in Washington County. This is the northern most county that PA St Rt 221 passes through. PA St Rt 221 passes through the following towns in Washington County. Taylorstown Prosperity Dunns Station PA St Rt 221 is multi-plexed in Washington County. Pennsylvania State Route 18, near Prosperity. PA St Rt 221 intersects the following highways in Washington County. Pennsylvania State Route 231, near Taylorstown. U.S. Rt. 40, near Lagonda. Interstate 70, near Lagonda. Pennsylvania State Route 18, near Prosperity. Pennsylvania State Route 18, near Prosperity.
