 |
Abstract of articles from |
| Indian Journal of Tuberculosis | |
| reproduced with kind permission |
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Vol 55 
No 3Jul 2008
ISSN 0019-5707 |
Original articles
- Evaluation of different types of chest symptoms for diagnosing Pulmonary tuberculosis cases in community surveys
- DOTS in drug addicts with TB:Delhi experience
- Is the quality of life different in patients with active and inactive tuberculosis?
- Relationship of Nitric Oxide and Protein Carbonyl in Tuberculosis
- Status report on RNTCP
Case reports
- Scapholunate dissociation :A rare presentation of TB wrist in a case of multi-focal skeletal tuberculosis
- An unusual case of pleural effusion with an abdominal mass
Short communication
Evaluation of different types of chest symptoms for diagnosing Pulmonary tuberculosis cases in community surveys
P.G.Gopi,R.Subramani and P.R.Narayanan
Background: Prevalence of tuberculosis(TB)is an important epidemiological index to measure the load of te disease in a community.A series of disease surveys were undertaken in rural community in Tiruvallur district in Tamilnadu ,South India
Objective: To investigate the yield of pulmonary tuberculosis(TB)cases by different symptom status and suggest predominant symptoms for detection of cases in the community based surveys Methods: Three disease surveys were conducted during 199 to 2006,in a random sample of 82000 adults aged 15 years and more to estimate the prevalence and incidence of pulmonary TB. All subjects were screened for chest symptoms and chest radiography.Sputum examination was done among those who were either symptomatic or abnormal on Xray or both.Cases observed through symptom enquiry were included for analysis.
Results: In survey-I 65.6% had cough of 14 days and more and yielded 79.1% of the total cases.In surveys II and III symptomatic subjects with cough contributed 69.5% and 69.2% of the cases respectively.In survey I 26.8% had symptoms without cough but with at least chest pain of cough of 1 month or more contributed 8.4% of total cases.The corresponding proportions in subsequent surveys were 29.3,11.5%;and 23.4,11.2% respectively.The number of symptomatics without cough and chest pain but with fever more than 1 month was negligible.
Conclusion The relative importance of cough as a predominant symptom was reiterated.The yield of pulmonary TB cases from symptomatics having fever of more than 1 month was negligible.Fever may be excluded from the definition of symptomatics for screening the population in community surveys.
Indian J Tuberc 2008;55:116-121
DOTS in drug addicts with TB:Delhi experience V.K.Dhingra,Dori Lall,Nishi Agarwal and R.P.Vasisht
Background Drug abuse is on the rise.Drug addiction lowers the general immunity of the body. Tuberculosis is known to be one of the major infectious diseases with a high incidence among drug addicts.Treatment of drug addicts suffering from tuberculosis is a challenge to the treating physician.
Methods: .An interventional prospective study which involved free de-addiction drugs and motivation along with free anti-tubercular drugs under revised national tuberculosis programme(RNTCP)was undertaken among drug addicts. Sixty drug addicts suffering from tuberculosis,registered under RNTCP in SPM Marg TB clinic(Pilikothi)between 2002 and 2007 and treated under DOTS along with de-addiction treatment by an NGO(Sharan)formed the study sample.
Methods A cluster sample house based tuberculin survey was carried out in a representative sample
Objectives: Objectives of the study were:
- To study the profile of drug addicts with tuberculosis
- To assess the success results of DOTS in drug addicts with tuberculosis (along with de-addiction treaatment)
Conclusion: DOTS along with with supplementary intervention was observed to be quite effective in drug addicts with TB.
Indian J Tuberc 2008;55:122-126
Is the quality of life different in patients with active and inactive tuberculosis?
Demet UNALAN,Ferhan SOYUER,Osman CEYHAN,MustafaBASTURK,Ahmet OZTURK
Objective: The aim of this study was to evaluate the quality of life(QOL)in outpatients with active and inactive tuberculosis,and to study the relations between QOL and demographic and socio-cultural characteristics and variables concerning the disease and depression.
Materials and Methods: Included in the present study were 196 active and 108 inactive cases who attended dispensary for tuberculosis within a 1 year period plus 196 healthy controls. In this study questionnaire form,SF36 quality of life scale and Beck depression inventory(BDI)were used.
Results: It was determined that in all fields of QOL,scores of the control group were higher than those of the patient groups. QOL scores in physical and social functionality dimensions of inactive cases were higher than in active cases(p< 0.001).As BDI scores increased in active and inactive cases,physical component summary(PCS)and mental component summary (MCS)decreased.As the treatment period increased in active cases,MCS increased.In active and inactive cases,marital status and accompanying diseases have an effect on the decrease of PCS scores(l<0.05).In patients with tuberculosis the QOL of men single patients with a high level of education and those not having the disease that accompanies tuberculosis were found to be high(p<0.05).The QOL was negatively correlated with age and BDI,while being positively correlated with monthly income,daily sleep period and treatment period(p<0.05)
Conclusion It is stated that in inactive tuberculosis cases,as in active cases QOL is deformed and demographic socio-cultural characteristics,depression,daily sleep period,treatment period and accompanying diseases are factors that affect quality of life.
Indian J Tuberc 2008,55,127-137.
Relationship of Nitric Oxide and Protein Carbonyl in Tuberculosis
Aruna KulKarni and Narayan.A.Madrasi
Background: Tuberculosis(TB is a highly contagious disease caused by Mycobacterium tuberculosis .The bacilli replicate within the macrophages and can remain dormant for years;Activated macrophages show immunity against these bacilli. Material and methods: A prospective study was carried out in newly diagnosed TB patients(n=70)before their anti-tuberculosis treatment and in normal control subjects(n=35).Serum level of nitric oxide was estimated by Moshage method,1995 and Bories and Bories method,1995 and protein carbonyl by Levine method,1990.Pearson's correlation(r and Fisher's "z" test was performed on the obtained results.
Results: In our study,serum nitric oxide and protein carbonyl levels were significantly increased(p<0.001)in TB patients as compared to normal control group.Positive correlation was seen in pulmonary TB[r=0.8892,p<0.001)(Fisher's "Z" transformed =0.7901 to 0.9430)and extra-pulmonary TB)r=0.8330,p<0.001)]Fisher's "z" transformed=0.6918 to 0.9128]"r" and Fisher's "z" was significantly different from zero(Two sided p<0.001).
Conclusion: The mean serum nitric oxide and protein carbonyl levels were concomitantly increased and positively correlated with each other in patients with pulmonary TB and extra-pulmonary-TB.The changes in the level of nitric oxide and protein carbonyl are a reflexion of increased defence mechanism and free radical activity in tuberculosis
Indian J Tuberc 2008,55,138-144
Status Report on RNTCP During the first quarter 2008
- Over 1.7 million pulmonary TB suspects were examined
- 00.22 million sputum positive cases were diagnosed
- A total of 368,969 TB cases were registered for treatment
- of which 147,778 were new sputum positive pulmonary TB(NSP)
- 97,909 were new smear smear negative (NSN) cases
- 53,057 were new extrapulmonary TB(EPTB) cases
- 69890 were retreatment cases
Scapholunate dissociation :A rare presentation of TB wrist in a case of multi-focal skeletal tuberculosis
Dhananjaya Sabat,Vinod Kumar and Ajay Gupta
Tuberculosis rarely involves wrist joint and is usually diagnosed in arthritic stage. Early presentations are easily confused with traumatic event and commonly missed.We describe a case presenting with cephalonate dissociation initially,which later progressed to full blown arthritis. Similar presentation has never been documented
Indian J Tuberc 2008,55,149-152
An unusual case of pleural effusion with an abdominal mass
Pretam.R.Acharya,Ramesh Chandra Sahoo and Poornima Baliga A 38 year old presented to us with a left sided pleural effusion. Pleural fluid was aspirated and analysis revealed it to be an exudate with lymphocytes and elevated ADA level.He was discharged on antituberculous treatment.Patient returned with re-accumulation of pleural fluid.Computed tomography done in our institute picked up not only parenchymal disease in the lung which was not evident on chest radiographs but also picked up an abdominal mass in left renal fossa.Pathological examination of excised mass revealed its tuberculous nature.The repeated recollection of pleural fluid was attributed to a "paradoxical response";The patient was reassured and his anti-tuberculous treatment continued.Recognition of the fact that evidence of tuberculosis at distant site may occasionally be needed to substantiate the diagnosis of tuberculous pleural effusion in a difficult and bacteriologically 'negative' case prompted us to report this case.
[Indian J Tuberc 2008;55:153-156
Annual risk of Tuberculosis infection in Chennai cityBR> P.G.Gopi,V..Venkatesh Prasad,M.Vasntha,R.Subramani,A.S.Tholkappian,D.Sargunan and P.R.Narayanan
Aim: To sttudy the proportion of children infected with Mycobacterium tuberclosis in Chennai city.
Methodology: A cluster sampling methodology was adopted to select an estimated sample size of seven thousand children from five corporation zones selected systematically fro ten zones of the city.A total of 7098 children aged 1-5 years were subjected to Mantoux and test read;1897(27%)from slum area and 5201(73%)from non slum area.
Results: The prevalence of infection among children without BCG scar estimated to be 10.5%(ARTI of 2.0%)and was sismilar to that among children irrespective of scar status.The prevalence of infection was higher among children in slum areas(11.1%)(ARTI 2-1%) compared to non slum areas(8.9% ARTI 1.&%);But the difference was not statiscally different.
Conclusion: The tuberculosis situation in Chennai as measured by risk of infection was higer in urban city area then rural areas and comparable to that found iin other cities as reported from earlier studies.This information can be used as baseline information for monitoring the epidemiological trends in Chennai city in futue.
[Indian J Tuberc 2008;55:157-161
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