- Disseminate info on TB in India
- Improve care of TB patients in India
- Enable doctors and NGO's interested in TB control to interact
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Objectives
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| Dosages and pharmacokinetics of antituberculosis medications | |||
| Drug | Usual adult dose | Peak serum concentration(µg/ml) | Usual range MIC |
| First line oral drugs | |||
| Isoniazid | 300mg | 3-5 | 0.01-1.25 |
| Rifampicin | 450-600mg | 8-20 | 0.06-0.25 |
| Pyrazinamide | 1500mg(30mg/kg) | 20-60 | 6.2-50 |
| Ethambutol | 15-25mg/kg | 3-5 | 0.5-2.0 |
| Injectable drugs | |||
| Streptomycin | 15mg/kg | 35-45 | 0.25-2.0 |
| Amikacin | 15mg/kg | 35-45 | 0.5-2.0 |
| Kanamycin | 15mg/kg | 35-45 | 0.5-1.0 |
| Capreomycin | 15mg/kg | 35-45 | 1.5-3.0 |
| Second line oral drug | |||
| Ofloxacin | 400mg bid | 8-10 | 0.25-2.0 |
| Ciprofloxacin | 750mg bid | 3-5 | 0.25-2.0 |
| Ethionamide | 250mg or tid | 1-5 | 0.3-1.2 |
| Para amino salicylic acid | 3G qidb | 40-70 | not Known |
| Cycloserine | 250mg bid or tid | 20-35 | not known |
| a bid=Twice a day. tid=Thrice a day qid=four times a day b 4g bid for new formulations c MIC=Minimal inhibitory concentration | |||