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Pokeballs
| Name | Use | Cost |
| Pokeball | Catches a Pokemon | $200 |
| Great Ball | Catches a Pokemon, better than a Pokeball | $600 |
| Ultra Ball | Catches a Pokemon, better than a Great Ball | $1200 |
| Safari Ball | Catches a Pokemon in the Safari Zone | 30 for $500 |
| Master Ball | Always catches Pokemon | None |
Stones and Fossils
| Name | Use | Cost |
| Fire Stone | Evolves certain Fire-type Pokemon | $2100 |
| Water Stone | Evolves certain Water-type Pokemon | $2100 |
| Thunder Stone | Evolves certain Lightning-type Pokemon | $2100 |
| Leaf Stone | Evolves certain Grass-type Pokemon | $2100 |
| Moon Stone | Evolves certain Pokemon | None |
| Helix Fossil | Used to get Omanyte | None |
| Dome Fossil | Used to get Kabuto | None |
| Old Amber Fossil | Used to get Aerodactyl | None |
Field Items
| Name | Use | Cost |
| Bicycle | Inceases speed over land | $1,000,000 |
| Escape Rope | Used to escape caves | $300 |
| Repel | Keeps Pokemon away | $350 |
| Super Repel | Keeps Pokemon away, better than Repel | $500 |
| Max Repel | Keeps Pokemon away, better than Super Repel | $700 |
| Old Rod | Used to fish in water | None |
| Good Rod | Used to fish in water, better than Old Rod | None |
| Super Rod | Used to fish in water, better than Good Rod | None |
Healing and Curing Items
| Name | Use | Cost |
| Anitdote | Cures "Poison" | $100 |
| Burn Heal | Cures "Burn" | $250 |
| Ice Heal | Cures "Frozen" | $250 |
| Awakening | Cures "Sleep" | $250 |
| Paralyze Heal | Cures "Paralyze" | $200 |
| Full Heal | Cures all ailments | $600 |
| Potion | Restores 20 HP | $300 |
| Super Potion | Restores 50 HP | $700 |
| Hyper Potion | Restores 200 HP | $1500 |
| Max Potion | Restores all HP | $2500 |
| Full Restore | Restores all HP and cures all ailments | $3000 |
| Revive | Cures "Faint" and restores up to half HP | $1500 |
| Max Revive | Cures "Faint" and restores all HP | None |
| Ether | Restores 10 PP of one attack | None |
| Max Ether | Restores all PP of one ability | None |
| Elixer | Restores 10 PP of all abilities | None |
| Max Elixer | Restores all PP of all abilities | None |
Power Up Items
| Name | Use | Cost |
| Rare Candy | Increases Pokemon's level by one | None |
| HP UP | Increases HP level | $9800 |
| Protein | Increases power level | $9800 |
| Iron | Increases defense level | $9800 |
| Carbos | Increases speed level | $9800 |
| Calcium | Increases special level | $9800 |
| X Attack | Increases attack in battle | $500 |
| X Defend | Increases defense in battle | $500 |
| X Speed | Increases speed in battle | $350 |
| X Special | Increases special in battle | $350 |
| Guard Spec | Enemy cannot use special in battle | $700 |
| Dire Hit | More effective attacks in battle | $650 |
| X Accuracy | Increases accuracy in battle | $950 |
| Poke Doll | Distracts opponents in battle | $1000 |
| PP UP | Increases PP level | None |
| Fresh Water | Restores 50 HP in battle | $200 |
| Soda Pop | Restores 60 HP in battle | $300 |
| Lemonade | Restores 80 HP in battle | $350 |
Special Items
| Name | Use | Cost |
| Pokedex | Holds Pokemon data | None |
| Town Map | Helps navigate in the world | None |
| TM | Technical Machine, teaches one skill to one pokemon | Varies |
| HM | Hidden Machine, teaches one skill to any number of pokemon | None |
Other Items
| Name | Use | Cost |
| Nugget | Sell for $5000 | None |
| Gold Teeth | Allows Safari Zone Warden to speak | None |
| S.S. Anne Ticket | Lets you aboard S.S. Anne | None |
| Silph Scope | Allows you to see the pokemon in the Pokemon Tower | None |
| Poke Flute | Wakes sleeping Pokemon | None |
| Itemfinder | Helps find hidden items | None |
| EXP All | Shares Exp among all pokemon | None |
| Coin | Used to play slots at Game Corner | 50 for $1000 |
| Coin Case | Holds 9,999 coins | None |
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