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Mercury in Vaccines

Threads - Mercury in Vaccines

On 8/8/2004, Gerald Cairnes posted:

am amazed that mercury should be in any systemic medicine these days.
Apparently used as a preservative in 5 in 1 vaccine for
infants??????????????????????

http://news.bbc.co.uk/go/em/-/1/hi/health/3544674.stm

Peter Macinnis replied:

My recollection is that the amount of mercury used is very small indeed, and that this is a very old claim.

John Winckle responded:

It was compared to the amount of mercury in half a tuna sandwich, (that is in all the child vaccinations combined) but you have to eat the half sandwich over five years.

Gerald cairnes answered:

I did not check the quantities or the story, however I don't believe it to be an appropriate material to be used in such a fashion - there are some things you just don't do whatever the background levels and they are a bloody sight higher than they ought to be by our own hand.

Jim Edwards added:

I would never even feed tuna to my cat since I was told by a vet that most tuna comes from Thailand where there is mercury pollution in the ocean and that it accumulates as it goes up the marine food chain to the tuna at the
top.

Paul Williams commented:

Thought that these sites may be of interest:
"Vaccines listed in the Australian Vaccination Schedule for Children have not contained thiomersal [an orgonomercurial] since 2000. All childhood vaccine stock in circulation is thiomersal free."
http://www.vaccination.org.au/questions/question2111.html

There doesn't appear to be any conclusive evidence that trace amounts of thiomersal are harmful. Nevertheless, it appears that possible neurological damage is plausible and a general movement away from this preservative is now being actively encouraged:

Daya Papalkar responded:

I am not sure why thiomersal is being used in this vaccine in the UK. As a preservative in vaccines, it has been used for many years, but as Paul has stated, there is a trend to removing it. This is apparently on the basis of minimising exposure to mercury rather than there being known adverse outcomes due to thiomersal levels used in vaccines. Not using thiomersal is obviously a good thing in terms of preventing *potential* for adverse
outcomes.

In Western countries, a very important issue is the perception of safety of the vaccine, not just the actual safety. Even though the mercury levels used in vaccines were below the accepted exposure limits, it is ammunition for
the anti-vaccination lobby. So removing thiomersal may be an important public health issue more in terms of vaccination rates/acceptibility rather than mercury toxicity (in Western countries).

As I have previously stated, IMO, in general, people are not good at calculating & comparing risks when the odds of the adverse events are very low. This is particularly true with vaccination, because many parents have no experience of the actual disease that is being vaccinated against.

In developing countries, thiomersal is used in multiple use vaccine vials.  The risk/benefit/cost analysis there is very different. Removing thiomersal may be prohibitively expensive for these countries (changing to single use
vials), and if that means lower vaccination rates, then that is a potentially far more hazardous outcome than giving small amounts of mercury with the vaccine.

The BBC article that Gerald referenced was alarmist & somewhat unbalanced. I think it is actually important for the media to remind people of the success of vaccination in preventing disease - it is too often portrayed as an
impost of government. The article did not mention that the live attenuated polio vaccine is far more effective at preventing polio than the killed vaccine. We can't assume that changing back to the old vaccine will not result in more cases of polio.

Gerald Cairnes replied to Daya:

I was not being alarmist when I referred to this article, not that you suggested I was being alarmist, but the mere use of metals like mercury and cadmium in what I suspect is an unnecessary application is not good policy. I can't offer any alternative preservative suggestions in this area - I have been too long away from matters biological. If it is not necessary then don't use it these things have a habit of coming back to bite you.

I see unnecessary applications of these metals all around us and must question why it is we still persist in spite of all of the so called proscriptions against them. Some time ago car manufacturers switched from brass welch plugs to cadmium plated steel plugs. I presume on a basis of cost. The result was that the cadmium was electrolytically removed in service or at the first time the engine was flushed with the cadmium trapped between the plug and the block setting up a differential current that rapidly corroded through the plugs. Brass or copper has none of these problems as they are far more easily corrosion protected chemically and do not represent a real problem in terms of pollution so why change, they can last a lifetime? They have ceased this practise I understand but it is a decision that should never have been made in the first place.

Another such application of cadmium is the plating on screws and bolts that again could be just as easily plated with passivated copper and present a risk many orders of magnitude lower than cadmium. I received a request from a client through an agent to comment on why fungal growth was occurring all over the Colourbond roofing except directly above the underlying purlins. Looking at the image it appears to be associated with a zone of inhibition around each roofing screw  and the adjacent zones have merged to produce the longitudinal zone illustrated. The longitudinal effect is well defined and there may be another explanation or compounding process at work here. Regardless if this is the correct interpretation it is an interesting effect and if I am correct then it is a good visual demonstration of why cadmium should not be used in these applications as it is dispersing into the environment in significant amounts over large areas to accumulate in the food chain. So many of these inappropriate substances are used because they happen to be low cost waste products from other processes.
Zoned Roof Fungus - Inhibited by cadmium  on bolts.

and to Paul:

It is not only a question of the toxicity of mercury per se, now where did I put my course of BAL, it is also the question of the toxicity of thiomersal (50% mercury approx) itself ending with the residual effects of mercury accumulation. I am not being alarmist simply making the point that although I do not have any immediate alternative suggestions I feel sure we can do better than this. As someone has already noted background levels may be low but this varies wisely from place to place bio- accumulation is an issue.

A quick Google will bring up some PDF's on the subject.

It is the same type of situation that we encountered recently with a certain government department who did not want to know so they shot the messenger and claimed I had a conflict of interest. Bullshit, they had not done the most fundamental of tests before choosing their material and the hands over arse syndrome took over at various levels. In this case there is a very serious public safety issue that could have been resolved quietly and sensibly in the public interest practically and financially, so now instead they have the publicity they did not want. It's called a whitewash!

Will the person who has nicked my BAL please return it quick, now I know why I have only two neurones left and I need them, so who do I sue. :-)

Daya Papalkar replied:

Yes, I know you weren't being alarmist, and I agree that we should avoid the use of these metals if possible. Changing from multiple use to single use vials can obviate the need for thiomersal; I am not sure about alternative preservatives. However, it is important to remember developing countries and the cost/benefit analysis there.

The following excerpt from a review may be interesting to some. "The
Toxicology of Mercury - Current Exposures and Clinical Manifestations"
Clarkson T. W., Magos L., Myers G. J. N Engl J Med 2003; 349:1731-1737, Oct
30, 2003.

"At concentrations found in vaccines, thimerosal meets the requirements for a preservative set forth by the U.S. Pharmacopeia - that is, it kills the specified challenge organisms and can prevent the growth of the challenge fungi. It contains the ethyl mercury radical (CH3CH2Hg+) attached to the sulfur group of thiosalicylate and is believed to behave toxicologically like other ethyl mercury compounds. Early toxicity studies found no adverse health effects; recently, however, Ball et al. reevaluated thimerosal by applying the revised EPA guideline for methyl mercury to ethyl mercury. They calculated that infants undergoing the usual U.S. program of vaccines from birth to six months of age would receive more than 0.1 µg of mercury per
kilogram per day. Steps were rapidly taken to remove thimerosal from vaccines by switching to single-dose vials that did not require any preservative. This process is now virtually complete in the United States.

The decision itself is remarkable, and the speed of execution even more so; however, the EPA guideline is based on epidemiologic data on prenatal exposure to methyl mercury rather than postnatal exposure to ethyl mercury. Ethyl mercury has some similarities to methyl mercury. They are closely related chemically, have a similar initial distribution in the body, and cause similar types of damage to the brain in toxic doses.

They also have differences. Methyl mercury is more potent. Ethyl mercury is metabolized more rapidly to inorganic mercury; perhaps this is why ethyl mercury, unlike methyl mercury, causes kidney damage in humans. Of greater importance is the recent finding that the half-life of ethyl mercury in the body is much shorter. The half-life of methyl mercury in blood, which is assumed to indicate the total body burden, is usually assumed to be about 50 days. In contrast, in children receiving thimerosal in vaccines, the half-life of ethyl mercury in blood was 7 to 10 days, or 1/7 to 1/5 as long as that of methyl mercury. Therefore, in the two-month periods between vaccinations (at birth and at two, four, and six months), all of the mercury should have been excreted, so that there is no accumulation.

Given the short half-life of ethyl mercury, any risks of its damaging either the brain or kidneys would seem remote. A World Health Organization advisory committee recently concluded that it is safe to continue using thimerosal in vaccines. This is especially important in developing countries, where the use of a preservative is essential in multidose vials. The known risk of infectious diseases far exceeds that of the hypothetical risk of thimerosal. Claims have been made that thimerosal in vaccines may be a cause of autism and related disorders, but studies testing that theory have yet to be performed."