U.S. Federal Route 45 runs through the extreme northwestern corner of Cumberland County. U.S. Rt. 45 passes through the following town in Cumberland County. Neoga U.S. Rt. 45 is multi-plexed in Cumberland County. Illinois State Route 121, from the Coles/Cumberland County Line to near Trilla. U.S. Rt. 45 intersects the following highways in Cumberland County. Illinois State Route 121, near Trilla. Interstate 57, near Neoga.
