U.S. Federal Route 52 runs north-south in Jackson County. It runs along the western banks of the Mississippi River. U.S. Rt. 52 passes through the following towns in Jackson County. St. Donatus Bellevue Sabula
U.S. Rt. 52 is multi-plexed in Jackson County. Iowa State Route 64, near Sabula.
The Iowa Welcome Sign on NB U.S. Rt. 52/WB IA St Rt 64. SB U.S. Rt. 52/EB IA St Rt 64 at the Mississippi River Bridge. SB U.S. Rt. 52/EB IA St Rt 64 at the main truss. SB U.S. Rt. 52/EB IA St Rt 64 crossing the Mississippi River. EB U.S. Rt. 52/EB IA St Rt 64 near the Illinois side.