INFO FOR PROSTATE CANCER In conjunction with �in general� suggestions Saw palmetto � used to treat benign prostatic hypertrophy. Best to use product that contains the lipid extract with a high fatty acid content. This is high in phytosterols.(85- 95%) Inhibits the metabolism of testosterone to its inactive form, dihydrotestosterone, which doesn�t compete with estrogen. Creates high risk of prostatic adenocarcinoma and BPH. May also be converted to estrogen( along with testosterone) in fat cell. Competes with testosterone for binding sites. Vitex � flavonoids found to reduce testosterone production and resulting conversion to estrogen. Zinc � deficiency of this can cause metabolism of �bad� estrogen in men. Don�t take more than 50mg/day DIM or Indol-3-Carbinol � supplementation of either of these may result in the healthy metabolism of the �good� estrogen. This does not signal the conversion of testosterone to estrogen. �good� estrogen also stops the process of cell division in abnormal cells. Protects the prostate from unwanted estrogen stimulation. The way to obtain these are by eating plenty of lightly steamed cruciferous vegetables Calcium D-glucurate � shown to have anti-estrogenic properties, an estrogen blocker. Very effective detoxifier. Inhibits the action of beta-glucuronidase which has been found to break the bond between estrogen and glucuronic acid in the liver � which allows the hormone to be reabsorbed back into the body rather than be excreted. Recommended dose has been found to be 200-400mg preventatively, or 400-1200 mg. with existing hormone related cancer. Chrysin � 500mg. 3 times a day. A natural aromatase-inhibitor blocking the conversion of testosterone to estrogen. The estrogen is the cause of the hormonal prostate cancer. Specifically, estradiol � which is the very strongest estrogen which we get from exposure to environmental estrogens or endocrine disruptors from pesticides, herbicides, plastics, all meat, dairy, eggs � unless organic, and other environmental toxins. They are in the air you breathe and the water you drink. Clinical results have shown a decrease in estrogen of up to 70%-80% and an increase in testosterone of 50%-100%. Testosterone is also converted to estrogen in the fat cell. Consequently, obesity is a risk for prostate cancer or any hormonal cancer. Not only is more estrogen produced, the estrogen that�s produced stimulates more fat cells to be produced. So, it�s a vicious circle. A proven effect for the concept of calorie restriction and attention to insulin metabolism. Excess insulin stimulates the production of more fat cells also. Insulin is a storage molecule, not a metabolism molecule. Restrict all dietary means of stimulating an insulin reaction. Panax ginseng � found to increase testosterone levels. Best not to use this with prostate cancer. Beneficial in healthy males. Is known to increase blood pressure. Modified citrus pectin � found to be extremely beneficial with prostate cancer. Shown to decrease development of metastases and inhibit adhesion of prostate cancer cells Increased intake of fat has been associated with increased incidence of prostate cancer. Omega �3s from fish oil are highly beneficial fats � shown to have inhibitory effect on cancer. May inhibit metastasis by inhibiting platelet aggregation. DHA in omega-3 competes for cell uptake with arachidonic acid and decreases platelet activating factor which inhibits tumors ability to induce angiogenesis. Try to take 1000mg./3X day. Best to take 1T. a day Nettle root � found to show specificity in the inhibition of prostate cancer. Also binds with Sex Hormone Binding Globulin ( SHBG), countering it�s effect on free testosterone. Thereby increasing levels of free testosterone. Free testosterone is not the cause of prostate cancer, it�s the conversion of testosterone to DHT � which is the inactive metabolite of testosterone � which does not counter estrogen. High doses of melatonin when given at night with a variety of chemo drugs has shown reduction in side effects or improvement. Shark cartilage � found highly effective against prostate tumors, achieving tumor reduction rates of 15-67%. Also lowers PSA counts in 12-16 weeks. ---implantation of radiation seeds into the prostate gland has been found to actually asten development of that cancer. Prostate cancer cells have been found to double in as little as 1.2 months after radiation as opposed to an average of 4 years with no radiation. Prostate surgery can release cancer cells into the blood. Drop in PSA from radiation is sustained in only 20% of patients. 90% will have cancer cells that now multiply 40 times faster than non-radiated cells. Shark cartilage attacks tumors via anti-angiogenesis. It contains no blood vessels and has proteins which prevent new vessels from forming. Shark cartilage works best with solid tumors. Does not interfere with normal angiogenesis for healing, therefore does not need to be stopped after surgery � is actually beneficial after surgery to aid in healing. Obesity creates a vicious cycle of conversion of testosterone into estrogen by an enzyme (aromatase) within the fat cells. This conversion to estrogen leads to the production of more fat cells. (increased weight) and �hence- the conversion of more estrogen. Age also increases the amount of aromatase. Chrysin blocks the aromatase. Progesterone blocks the estrogen. Dietary fiber intake may influence circulating levels of testosterone and estradiol, thereby affecting the prostate cancer biology which may decrease the progression of prostate cancer. Testosterone, in and of itself, does not cause prostate cancer. The male body is exposed to and makes estrogen (estradiol) and progesterone just as women do. They do this in much lower amounts. The testosterone is antagonistic to estradiol (which is the primary cause of both breast and prostate cancer) by destroying the prostate cancer cells that the estradiol stimulates. The progesterone prevents the male body from converting testosterone to di-hydro- testosterone, which DOES NOT destroy the cancer cells that estradiol stimulates. Progesterone does this by inhibiting an enzyme called 5-alpha reductase. However, as the male body ages, progesterone levels decrease. When this happens, the male�s 5-alpha reductase then converts testosterone to di-hydro- testosterone which is useless and, in a sense, promotes prostate cancer growth. Studies have also shown that progesterone stimulates the p53 gene which controls cell growth and inhibits cancer. Continuing research is showing that men using natural transdermal progesterone cream use doses about half of what a woman would use. This would be about the size of a small pea. It is suggested that the cream be used in small doses twice a day. Men do not have cyclic hormonal patterns as women do, so , they are able to use it without taking time off as women do. As with women, progesterone has been found to increase bone density.That would make progesterone very beneficial in osteoporosis. It is also found that, in balancing the estrogen in the body, progesterone helps the thyroid hormone to be more effective. Estrogen has been found to mask the effects of the thyroid hormone. Because prostate cancer is a slow-growing cancer, studies show that nutritional interventions may spare patients from undergoing toxic and various treatments and improve quality of life. Vit D3 (active form) found to inhibit growth and invasiveness of prostate cancer cells. Soy found to be highly beneficial in treatment and prevention of prostate cancer- in small amounts --- genestein and diadzen shown to inhibit growth of androgen dependent and androgen independent prostatic cancers --- inhibits angiogenesis � preventing growth and metastasis --- inhibits activity of cellular receptors for EGF-1, insulin, IGF-1, and PGF-1 --- best to use soy in it�s complete form � as soy beans, or tofu or fermented soy powder (drink) --- studies have shown that other components of soybeans which are not isoflavones may be responsible for anti-cancer effects. --- scientific evidence is now allowing soy to be tested clinically as an adjuvant therapy for prostate cancer. .