Misty
Misty first met Ash when he stole her bike as she was fishing for water Pokémon. She soon caught up with him at the nearest Pokémon Center in Viridian City. Misty came to see the power in Ash's love for Pokémon and joined up beside him, wanting to be the greatest Pokémon Trainer ever! She also wanted him to pay her back for the bike he had stolen and crashed. After Misty and Ash met up with Brock, their journey led them to Cerulean City, the birthplace of Misty. The two boys soon learned that she was the little sister of the three gym trainers there. Misty battled Ash to show her sisters what she had learned after running away from Cerulean City. During the battle Misty showed her skill of being a Pokémon trainer for the first time. From then on she and Ash became better friends but stayed the comedic element in the show when they bickered with eachother constantly on their journey to find more Pokémon!
Brock
Brock was the Gym trainer in Pewter City when Ash and Misty first met him. This older member of the trio was deserted by his father early in life and was given the responsibility of raising his many little brothers and sisters. After Brock saw Ash had truly earned a badge, he followed him and Misty on their adventure. Brock left only because his father who had finally returned agreed to take care of his siblings. During battles with Team Rocket, Brock showed his true ability to fight and capture Pokémon. This was not his true calling though, since Brock only wished to be a Pokémon breeder, not trainer. His expertise on Pokémon also helped Ash many times throughout his journey of capturing, training, and fighting different Pokémon.
Proffesor. Oak
Professor Oak is Pallet Town's expert on Pokemon; he is the one who prepares prospective Pokemon trainers to go out into the world, although he can be a little absent-minded at times. He offers encouragement to Ash whenever he can. Ash's rival Gary, is unfortunately Oak's grandson.