CURRICULUM VITAE

Beverly A. Tinkelenberg

Contact                    Department of Molecular Biology                                    

Information:           University of Medicine and Dentistry of New Jersey                 

                                    Two Medical Center Drive                                                   

                                    Stratford, New Jersey  08084                                                 

                                    Phone:  (856) 566-6046

                                    Fax:  (856) 566-6291

                    email:  mastraba@umdnj.edu                                                          

Education:

1993-1997:  Mount St. Mary’s College, Emmitsburg, MD: B.S. (Biology)

1998-present:  University of Medicine and Dentistry of NJ, Stratford, NJ: Ph.D. candidate (Molecular Biology)

Awards and Activities:

1997                Summa Cum Laude Graduate

1997                Seton Memorial Prize for Highest GPA in Biology

1997                Lewis McAllister Memorial Prize for Excellence in the study of music

1993-1997            George Henry Miles Honor Society – council member

1993-1997            Delta Epsilon Sigma Honor Society

1993-1997            Beta Beta Beta Honor Society

1993-1997            Monsignor Tierney Honor Society

1996-1997            Mount St. Mary’s Golf Team

2001-present            UMDNJ-SOM Library Committee

2001-2002            Graduate Student Association - Treasurer

Major Research Interests:

Development and validation of molecular targets for cancer chemotherapeutic drug development.  Development of prognostic markers for overall survival and tumor response to chemotherapy in gastrointestinal cancers. 

Research and Work Experience:

1995-1997       Teaching Assistant: Physics, Concepts of Physical Science, and Organic Chemistry, Mount St. Mary’s College

1996                Summer Research Intern, Department of Molecular Biology,             UMDNJ

1998-2000            Teaching Assistant, Microbiology, UMDNJ-School of Osteopathic Medicine

1997-present             Research Teaching Specialist, Department of Molecular Biology, UMDNJ-SOM,                                                   Stratford, N.J.

Other Interests:

Horseback riding

Golfing

Biking

Jogging

PUBLICATIONS:

Muller-Weeks, S., Mastran, B., and Caradonna, S.  (1998) The Nuclear Isoform of the Highly Conserved Human Uracil-DNA Glycosylase Is an M_r 36,000 Phosphoprotein.  J. Biol. Chem. 273, 21909-21917.

Tinkelenberg, B.A., Hansbury, M., and Ladner, R.D.  (2002) dUTPase and Uracil-DNA Glycosylase are Central Modulators of Antifolate Toxicity in Saccharomyces cerevisiae.  Cancer Research 62, 4909-4905.

Tinkelenberg, B.A., Fazzone, W., Lynch, F., and Ladner, R.D.  (2003) Identification of Sequence Determinants of Human Nuclear dUTPase Isoform Localization.  Experimental Cell Research (in press)

Elateri, I.*, Tinkelenberg, B.A.*, Hansbury, M., Caradonna, S., Muller-Weeks, S., and Ladner, R.D.  (2003) hSMUG1 Can Functionally Compensate for Ung1 in the Yeast Saccharomyces cerevisiae.  DNA Repair (in press).        

Presentations and Abstracts:

2002: Mastran-Tinkelenberg, B.A., Hansbury, M.J., Ladner, R.D.,  “Effects of Inactivated Uracil-DNA Repair on Antifolate-induced Toxicity and Checkpoint Initiation in Saccharomyces cerevisiae”.   93^rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002, San Francisco, CA.

2002: Koehler, S., Mastran-Tinkelenberg, B.A., Lynch, F., Ladner, R.D.,  “Evaluation of dUTPase-induced Resistence to Thymidylate Synthase Inhibitors Utilizing Adenoviral Mediated Gene Transfer of Human dUTPase Isoforms”.  93^rd Annual Meeting of the American Association for Cancer Research, April 6-10, 2002, San Francisco, CA.

2002: Mandola, M.V., Rupert, D., Tinkelenberg, B.A., Lynch, F.J. and Ladner, R.D. Functional characterization of the human dUTPase promoter.  AACR special conference: Colon Cancer: Genetics to Prevention, Phialdelphia, PA.

2001: Mastran, B.A., Lynch, F.J., and Ladner, R.D., “Intracellular Localization of Nuclear and Mitochondrial Isoforms of dUTPase is Determined by their Respective Amino Termini”.  92^nd Annual Meeting of the American Association for Cancer Research, New Orleans, LA.

2000: Ladner, R.D., Mastran-Tinkelenberg, B.A. and M.J. Hansbury.  Aberrant Uracil-DNA Metabolism Activates Three Distinct Checkpoints in Saccharomyces cerevisiae.  LXV Cold Spring Harbor Symposium, Biological Responses to DNA Damage, Cold Spring Harbor Laboratory, NY.

2000:  Ladner, R.D., Mastran-Tinkelenberg, B.A., Meyer, A., Wisniewski, T.J., Geng, L., Muller-Weeks, S., and Henry, M.F.  The Role of Uracil-DNA Metabolism in Mediating Antifolate Cytotoxicity in Saccharomyces cerevisiae. 91st Annual Meeting of the American Association for Cancer Research, San Francisco, CA.

2000:  Mastran-Tinkelenberg, B.A., Hansbury, M.J. and Ladner, R.D.  The Role of Uracil-DNA Metabolism in Mediating Thymineless Death in Saccharomyces cerevisiae:  Implications for Cell Cycle Checkpoint Control.  The University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine, Fourth Annual Research Day, Stratford, NJ.

2000:  Meyer, A., Mastran-Tinkelenberg, B.A., and Ladner, R.D. The Role of dUTPase and Uracil-DNA Glycosylase in Mediating Antifolate Cytotoxicity in Saccharomyces cerevisiae.  The University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine, Fourth Annual Research Day, Stratford, NJ.

2000:  David MacBride, D., Mastran-Tinkelenberg, B.A., and Ladner, R.D.  A Genetic Screen for Temperature Sensitive Mutants of dUTPase in Saccharomyces cerevisiae.  The University of Medicine and Dentistry of New Jersey - School of Osteopathic Medicine, Fourth Annual Research Day, Stratford, NJ.