Fictional US-2 has a north-south alignment through the state. The fictional portion runs from Macinac Island, MI, multiplexed with I-75 over the bridge, then as either full freeway or partial limited access to suppliment I-75 down to Detroit. From Detroit to the state line, US-2 is multiplexed with I-75. I-75 multiplex: Exit numbers are dually signed on this exit list. The first number is the fictional exit number on US-2. The second number (the one in parenthesis) is the already existing exit number on the multiplexed interstates.
| Exit Number/Mile Marker | Eastbound | Westbound | Other Features | ||||||||
| Mile 305.54 |
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| WEST REAL
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Mile 305.54 (344) |
Sault Ste Marie |
Jump to fictional MI-666 | |||||||||
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| Mile 306.54 (343) | Macinac Island Bridge PAY TOLL $1.50 |
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| Mile 309.54 (340) | Macinac Island Bridge PAY TOLL $1.50 |
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| 310A (339B) | SOUTH FICTIONAL
Hell |
Jump to fictional MI-666 | |||||||||
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| 310B (339A) | SOUTH
Local to Flint |
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| 311 (338) | SOUTH
Detroit |
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EAST
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| Mile 320.54 | Levering Road | 
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| Mile 321.04 |
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326 |
Silver Beach |
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340 |
Tower |
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367 |
Atlanta |
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392 |
Curran |
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406 |
Glennie |
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| Mile 425.54 |
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| Mile 428.04 |
Hemlock |
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| Mile 445.04 |
Twining |
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| Mile 451.04 |
Omer |
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| Mile 462 |
Worth |
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| Mile 480.04 | Beaver Road |
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| Mile 483.54 |
North Euclid Ave. |
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| 484 | Wilder Road | ||||||||||
| 485A | East Midland Road | ||||||||||
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485B |
Bay City |
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| 486 |
Lafayette Avenue |
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| Mile 500.19 |
Reese |
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| Mile 509.19 |
Frankenmuth |
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| Mile 522.22 |
Millington |
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| Mile 538.91 |
Lapeer |
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| 541A | WEST
Flint |
Exit 156 |
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541B |
London, ON |
Exit 156 |
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| Mile 551.19 |
Thomas |
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| 564 | Goodison | ||||||||||
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575 |
Utica |
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| 576 | 19 Mile Road | ||||||||||
| 580 | Metro Parkway Utica Road |
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| 582 | 14 Mile Road Frasier |
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| 583 | Groesbeck Highway | ||||||||||
| 585 |
Roseville |
Exit 26A |
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| 589 |
Ann Arbor |
Exit 221 |
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| 591 | Mack Avenue | ||||||||||
| 595 |
Gratiot Avenue |
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| 597 |
Auburn Hills |
Exit 53 |
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| 598 |
Woodward Avenue |
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| 600 |
Michigan Avenue |
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| 601 |
West Fort Street |
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| 602 |
John C. Lodge Freeway |
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WEST
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| 605A (46B) | NORTH
Auburn Hills |
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| 605B (46A) | Dragoon Avenue Livernois Avenue |
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| 606 (45) | Springwells Avenue | ||||||||||
| 607 (44) | Dearborn Avenue | ||||||||||
| 608A (43B) | Shaefer Highway NORTH | ||||||||||
| 608B (43A) | SOUTH
Fort Street |
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| 608 (43) | SOUTH
Fort Street |
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| 609 (42) | Outer Drive | ||||||||||
| Mile 609.69 (42.75) |
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| 610 (41) | SOUTH
Southfield Highway |
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| 611 (40) | Dix Highway | ||||||||||
| 614 (37) | North Line Road Allen Road |
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| 615 (36) | Eureka Road | ||||||||||
| 616 (35) |
Telegraph Road |
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| 617 (34) | TO
Dix Highway |
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| 619A (32B) | West Road WEST | ||||||||||
| 619B (32A) | West Road EAST | ||||||||||
| 622 (29) | Flat Rock Gibralter |
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| 623 (28) | NORTH
Fort Street |
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| 624 (27) | North Huron Drive Rockwood |
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| 625 (26) | South Huron Drive South Rockwood |
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| 630 (21) | Newport Road Newport |
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| 631 (20) | NORTH
Romulus |
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| 633 (18) | Nadeau Road | ||||||||||
| 636 (15) | Dixie Highway | ||||||||||
| 637 (14) | Elm Street | ||||||||||
| 638 (13) | Front Street | ||||||||||
| 640 (11) | Bolles Harbor LaPlaisance Road Downtown Monroe |
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| 642 (9) | S. Otter Creek Road LaSalle |
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| Mile 644.04 (7.50) | Weigh Station ALL TRUCKS MUST ENTER |
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| 645 (6) | Luna Pier | ||||||||||
| 646 (5) | Erie Road | Erie Temperance |
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| 649 (2) | Erie Temperance |
Sterns Road Point Place, OH |
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| Mile 651.54 (0.00) | WELCOME TO OHIO | WELCOME TO MICHIGAN | |||||||||
| SEE THE ENTIRE OHIO EXIT LIST | |||||||||||
| SEE ONLY THE TRUE FICTIONAL OHIO EXIT LIST | |||||||||||
