| NAME | ORIGIN | REFERENCE | PROPERTIES |
| Acetin | Naturally occurring. | DS9: Paradise | Acetin deposits in the swamp beds near Alixus' community created duonetic fields that prevented equipment from operating. |
| Acetylcholine | Naturally occurring. | DS9: Melora | Bashir used a medication designed to increase acetylcholine absorption to increase Melora's tensile muscular strength, thus enabling her to walk. |
| Acetyline | Artificially generated by crew | Star Trek: Episode Name | A general anesthetic. |
| Acid Dichloride | Artificially generated by crew. | VOY: Threshold | A gaseous chemical The Doctor determines that the evolved Tom Paris requires to breathe. |
| Actinides | Naturally occurring. | TNG: The Mind's Eye | Radioactive compounds generally found in uranium ore. Actinides are known to interfere with Federation sensors. The crew of the Enterprise encountered these in the Ilkalian asteroid belt. The actinides made it difficult to locate the Kriosian rebels. |
| Adenosine triphosphate | Naturally occurring. | VOY: Sacred Ground | A natural neuro-chemical produced by the brain. Janeway's adenosine triphosphate levels has increased which suggests that she is going through a grueling experience. |
| Alazine | Artificially generated by crew. | VOY: Darkling | The Doctor gives Torres 10 cc's of alazine after she is found unconscious in sickbay. |
| Anesthezine | Artificially generated by crew. | DS9: The Siege of AR-558 | A general anesthetic. Fatal if present in the air. |
| Anetrizine | Artificially generated by crew. | VOY: The Gift | An anesthetic used on Seven's cranial nerves. |
| Animazine | Artificially generated by crew. | VOY: Waking Moments | A stimulant used to prevent the crew from going to sleep. |
| Antimonium | Origin unknown. | DS9: Business As Usual | Quark's investment in antimonium options were wiped out. |
| Archybite | Naturally occuring. | DS9: The Nagus | A substance gouge-mined in the Clarius system. |
| Argine | Origin unknown. | DS9: The Nagus | Used in the construction of Ferengi Locator Bombs. |
| Argonite | Origin unknown. | DS9: Doctor Bashir, I Presume | A gas with rising levels in the station's air supply, though it was still well within safety margins. |
| Astatine | Naturally occuring. | DS9: Paradise | A substance which Alixus claimed was probably responsible for the neutralized EM readings on her colony's planet. |
| Astilinee | Origin unknown | VOY: Tattoo | The polyferranide deposit that Torres finds is contaminated with astiline. |
| NAME | ORIGIN | REFERENCE | PROPERTIES |
| Baakonite | Naturally occuring. | DS9: Blood Oath | Dax's bat'leth was made of this metal. |
| Bakrinium | Naturally occuring. | DS9: The Sword of Kahless | A mineral mined on a planet located in the Gamma Quadrant, which was later revealed to be the Hur'q homeworld. |
| Barium | Naturally occurring. | VOY: Tuvix | Barium was administered by physicians until the late 21st century to patients with certain gastrointestinal conditions; the radioactive properties of the barium made the lining of the intestines visible with an imaging technology called X-rays. |
| Benzine | Naturally occuring. | DS9: Improbable Cause | Yalosians breath an atmosphere that is 10% benzine. |
| Beritium | Naturally occuring. | DS9: The Search, Part I | Used in construction of Bajoran earrings. |
| Bicaridine | Artificially generated by crew. | TNG: The First Duty | A painkiller. Wesley Crusher is allergic to metorapan treatments, so he is treated with a bicaridine substitute instead. |
| Bilitrium | Naturally occurring. | DS9: Past Prologue | A rare crystalline element which can be an incredible source of energy if hooked up to an anti-matter converter. |
| Birythium | Naturally occuring. | DS9: The Jem'Hadar | Found on the planet Sisko, Jake, Quark and Nog went camping. |
| Bitrium | Naturally occurring. | TNG: The Silicon Avatar | Bitrous fibers were found on planet after crystalline entity had left. The crew theorized that bitrium was a byproduct of the consumption of biological matter. |
| Boridium | Artificially generated by crew. | TNG: The Quality of Life | Used as a power generator or convertor in compact machines and devices. |
| Boronite | Naturally occurring. | VOY: Real Life | Voyager finds this in the composition of the debris field where the Vostigye station should be. |
| Brizeen nitrate | Artificially generated by aliens. | DS9: Rules of Acquisition | Zek offered 50,000 kilos of it to Bajor in order to conduct business with the Dosi on DS9. |
| Byzatium | Origin unknown. | DS9: Defiant | Six transports of it were on the way. |
| NAME | ORIGIN | REFERENCE | PROPERTIES |
| Cabrodine | Artificially genereated by aliens. | DS9: In the Hands of the Prophets | Neela used it in combination with infernite to bomb the DS9 schoolroom. |
| Calendenium | Naturally occurring. | TNG: Night Terrors | Chemical and possibly an element. Combined with hydrogen released by the Enterprise by the alien ship in order to produce a massive chemical explosion to free both vessels from the Tychon rift. |
| Carbon neutronium | Artificially generated by aliens. | TNG: Relics | The shell of the Dyson sphere was composed of carbon neutronium. A phaser blast was ruled out as an option to get out of the sphere because it would be ineffective. |
| Carbon 60 composites | Origin unknown. | VOY: Real Life | Used in space station construction. Voyager finds this in the composition of the debris field where the Vostigye station should be. |
| Carbrodine | Origin unknown. | DS9: In the Hands of the Prophets | When mixed with infernite, becomes explosive. |
| Castrodinium | Naturally occurring. | TOS: Balance of Terror | The hardest substance known to Federation science. The outer protective layers of Federation outposts along the Romulan neutral zone are composed of this material. However, even with an outpost buried miles underground, it provided insufficient defense against the Romulan energy weapon. A piece of the destroyed shield was crushed by Spock. |
| Catoline | Artificially genereated by crew. | VOY: Darkling | The Doctor uses catoline to simulate Torres's anaphylactic shock in order to fool Janeway and Tuvok. |
| Cervaline | Artificially generated by crew. | VOY: Lifesigns | Unknown function. Kes administered 500 milligrams of this drug every 4 hours to Danara as the Doctor has instructed. |
| Chemicite | Origin unknown. | DS9: Little Green Men | A highly explosive compound, dangerous to transport, can be sold for a good profit on Orion. A cascade reaction in the chemicite caused Quark's shuttle to be flung through time. |
| Cobalt Diselenide | Artificially generated by crew. | DS9: For the Uniform | A chemical compound that is considered a biogenic weapon. Cobalt dinitrate is harmless to most humanoids but is lethal to Cardassians. |
| Coladrium | Naturally occurring. | DS9: Captive Pursuit | Space matter collected by the arva nodes in Tosk's ship. |
| Corbomite | Artificially generated by Captain Kirk. | TOS: The Corbomite Maneuver | A fictional substance which supposedly reflects weapon fire back at the attacker. |
| Cordrazine | Artificially generated by crew. | TOS: City on the Edge of Forever | A stimulant. |
| Cormaline | Naturally occurring. | DS9: The Ship | A useful, relatively common mineral found in vast deposits on Torga IV. Sisko and an away team were conducting a mineral survey to determine the feasibility of a mining operation there. |
| Corodum | Artificially generated by crew. | TNG: Disaster | Used in thruster packs. |
| Corundium | Artificially generated by aliens. | DS9: The Forsaken | The material of which the probe that brought "Pup" to the station appeared to be made. |
| Cryptobiolin | Artificially generated by aliens. | TNG: The Hunted | An alien equivalent of steroids. During a checkup on Roga Danar, Beverly discovered high levels of cryptobiolin and other drugs in Danar's body. |
| Cyanoacrylate | Naturally occurring. | TNG: The Child | In real life, cyanoacrylate ester is Crazy Glue. According to Data, Eichner radiation, which caused genetically altered spores in stasis cage to expand uncontrollably and threaten the Enterprise, is released by "certain cyanoacrylates." |
| Cyrillium | Naturally occurring. | VOY: Flashback | Occurs in nebulae/gaseous anomalies in Delta and Alpha quadrants. Highly combustible. Collected by Voyager for use as an energy source; used by Sulu to disable Klingons. |
| NAME | ORIGIN | REFERENCE | PROPERTIES |
| Dermateralean Plasticine | Artificially generated by aliens. | DS9: Duet | Marritza was using the plasticine to preserve his appearance as Gul Darhe'el. |
| Deuridium | Naturally occurring. | DS9: The Passenger | Found as deposits in asteroid fields. The Kobliad need deuridium to stabilize their cell membranes in order to survive. |
| Deuterium | Naturally occurring. | TNG: Phantasms | Isotope of hydrogen, having twice the mass of ordinary hydrogen, also called heavy hydrogen. Used to power the warp core. Deuterium and antideuterium are combined to provide energy. |
| Diamide | Naturally occuring. | DS9: The Search, Part I | Used in construction of Bajoran earrings. |
| Diburinium | Origin unknown | TOS: By Any Other Name | A metallic substance. The Kelvins imprisoned Captain Kirk and company in a cave composed of a substance described by Spock as "similar to diburinium, but much denser." |
| Diburnium-osmium Alloy | Artificially generated by aliens. | TOS: That Which Survives | A substance highly resistant to energy and radiation. The Kelandans made an artificial planet out of a diburnium-osmium alloy. |
| Dicoromium | Naturally occurring. | TOS: Obsession | An element that makes up part of the molecular structure of a gaseous creature, possibly allowing the creature to exist in a state on the border between matter and energy and avoid weapons fire by moving itself through time. |
| Dilithium | Naturally occurring. | TOS, TNG, VOY: all | Focuses energy into highly concentrated form. Necessary for the operation of warp drives, and a vital part of a starship's power system. |
| Dolamide | Origin unknown. | DS9: Dramatis Personae | Used in power generators, reactors, and short-range transporters. If pure enough, it can be made into weapons. |
| Dopamine | Naturally occurring. | VOY: Scientific Method | The aliens have been increasing Janeway's dopamine levels to see how much more strain she can bear. |
| Duranium | Artificially generated by crew | TNG: Hollow Pursuits | A hard metal alloy. Used in construction of access tunnels on DS9; impervious to normal sensors. The outer shielding of the warp core is made of duranium. |
| Dycosilium | Origin unknown. | TNG: A Matter of Perspective | Optic material used to build lenses and mirrors. Used to build Kreeger wave generator. |