Site hosted by Angelfire.com: Build your free website today!

Subir K. Roy Chowdhury, M.D., Ph.D.

 

302 Mandalay Drive, Winnipeg MB   R2P 1K2 CANADA

 

skr_chowdhury@yahoo.ca Tel: 204-235-3574 (office), 204-221-6951 (home) &

204-995-6183 (cell)

 

 

Professional Profile

 

q  Mitochondrial Research Scientist and Biochemist with several years of experience in diabetes, cardiovascular diseases, inherited metabolic mitochondrial disorders, neuromuscular and neurodegenerative diseases, andcancer

 

q  Expertise in evaluation of mitochondrial physiology and function in different types of tissues and cultured cells (Oroboros oxygraph, Seahorse XF analyzer)

 

q  Extensive experience, knowledge and skills in the areas of Biochemistry, Molecular and Cellular Biology

 

q  Sound knowledge of Clinical Trial Research Methodology

 

q  Well-published researcher with vast experience in experimental research and teaching with strong interpersonal and communication skills

 

 

Career Summary

 

Research Associate, University of Manitoba, Winnipeg, Canada, 2006 – present

 

q  Investigating the role of mitochondrial dysfunction in impaired insulin signaling that lead to the progression of diabetic neuropathy

 

q  Exploring the importance of BNip3 proteins, hypoxia and mitochondrial death pathway in cardiac ischemia

 

q  Evaluated the role of oxidative stress in the development of cardiovascular complications and endothelial dysfunction due to diabetes-associated atherogenic lipoproteins

 

                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                                        

 

Postdoctoral Fellow, McMaster University, Hamilton, ON, Canada, 2002 – 2006

 

q  Evaluated the importance of glycolysis, mitochondrial dysfunction, oxidative stress in cancer progression

 

q  Investigated the role of mitochondrial glycerophosphate dehydrogenase in production of reactive oxygen species in cancer (prostate, breast, ovarian)

 

q  Developed methods to detect free radical formation from mitochondria

 

 

Graduate Student and Research Assistant, Charles University, Prague, Czech Republic

 

q  Studied the functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome and functional evaluation of respiratory chain enzymes of mitochondria in neuromuscular disorders

 

q  Investigated the role of mitochondrial glycerophosphate dehydrogenase as an active site of hydrogen peroxide production in mammalian mitochondria

 

q  Developed a systematic methodology for prenatal diagnosis of mitochondrial inherited disorders in cultured amniocytes

 

 

Specialized skills and Techniques

 

Diagnostic Assay Design:

 

q  Experienced in sample preparations using clinical samples from blood, tissues and cultured cells.

 

 

Tissue Culture Techniques:

 

q  Expertise in culture of cell lines (various types of endothelial, cancer, and neuronal) as well as in primary cell cultures (skin fibroblasts; human embryonic cells – amniocytes; dorsal root ganglion cells).

 

 

Cell-based Assays:

 

q  Expert in cell-based assays using fluorescence, absorbance and luminescence based detection methods.  

 

 

Protein Biochemistry Techniques:

 

q  Expert in measurement of mitochondrial reactive oxygen species, measurement of respiratory chain enzyme activities, membrane potential, Western blot analysis, immunochemistry, preparation of tissue extracts, protein purification, subcellular fractionation, receptor characterization and general radioisotope techniques.                                                                                                          

 

 

Molecular Biology:

 

q  Experienced in recombinant DNA techniques, RNA and DNA isolation, Real-Time PCR, thorough understanding of GFP and RFP fusion proteins and transfections. Design and transfection of targeted reporter vectors. Principle and application of siRNA technology.

 

 

Animal Care:

 

q  Oriented in animal research ethics, small animals handling and dissection.

 

 

Specialized Instrumentation:

 

q  Experienced in cellular biology techniques and biochemical assay development (Spectrofluorometry, FACS techniques, UV-Vis spectrophotometers, microscopy). Expert in using the OROBOROS oxygraph and Seahorse XF analyzer for the functional evaluation of mitochondrial complexes with specific inhibitors in isolated mitochondria and lymphocytes, cultured cells and muscle. Expert in the isolation of mitochondria from different tissues: different nerve tissues (brain, spinal cord, sciatic nerve, dorsal root ganglia), liver, heart, muscle, various types of cells. Experienced in isolation of low-density lipoproteins (LDL) from human blood.

 

 

Clinical Research Trial Methodology:

 

q  Extensive knowledge of principles and practices of clinical trial research methodology. Knowledgeable in research ethics and regulatory affairs, the duties of managing and organizing a clinical trial, the ethical guidelines, issues and challenges of conducting research on human subjects, basic biostatistical concepts and methods required in the development and implementation of a clinical trial and the analysis and interpretation of data.

 

 

Computer Skills and Personal Attributes:

 

q  Strong PC skills and able to use Corel draw, Sigma scan, Graph Pad Prism, SPSS. Expertise in reference management (EndNote, Reference Manager), experienced in planning, writing and proofreading scientific papers for publication in referred journals, eexperienced in searching referred journal databases, able to prepare graphics and illustrative materials, proficient in time management and prioritization, excellent organizational and record keeping skills, attention to details and accuracy, hard working with initiative, detail oriented and team player, excellent communicator with ability to work under minimal supervision, problem identification and trouble-shooting capabilities, adaptable to flexible work hours. Experienced in training and supervision of graduate, undergraduate students and research staff.  Multilingual: English, Bengali, Czech and Slovak.

 

 

Education

 

q  Certified Clinical Research Associate (completed 3 semesters, out of 5, McMaster University, Hamilton, Ontario, Canada, 2005-2006

 

q  Ph.D. /Biochemistry and Pathobiochemistry/ Charles University, Prague, Czech Republic                                                                      

 

Dissertation Title: “Biochemical and Functional Manifestations of Inherited Disorders of the Respiratory Chain”. 2002

 

q  M.D. /General Medicine/ Charles University, Prague, Czech Republic, 1997

 

 

Supplementary training, Courses and Workshops

 

q  Seahorse Bioscience Introductory XF Training Course, Billerica, Boston, USA, 2011

 

q  DaleCarnegie® Course, Hamilton, Ontario, Canada, 2003

 

q  The Socrates Intensive Program on "Cellular Energetics and Regulation", Konstanz, Germany, 2001

 

q  Study stay for training in spectrophotometric analysis for the optimization of mitochondrial enzymes at the Department of Biochemistry, Erasmus University, Rotterdam, Netherlands, 2000

 

q  Seminar on "Standardisation of Methods for the Diagnosis of Mitochondrial Diseases." Salzburg, Austria, 1999

 

q  Molecular diagnostics in Oncology, 1st Medical Faculty, Charles University, Prague, Czech Republic, 1999

 

q  Basic DNA diagnostics, 1st Medical Faculty, Charles University, Prague, Czech republic, 1998

 

q  Advances of Molecular Biology in Genetics, 1st Medical Faculty, Charles University, Prague, Czech Republic, 1998

 

q  Introduction to methodology in science, 1st Medical Faculty, Charles University, Prague, Czech republic, 1997

 

 

Awards, Scholarships and Recognitions

 

q  Editorial board member of “Journal of Diabetes and Metabolism” since 2010

 

q  Invited reviewer of the journals “Free Radical Research” and “International Journal of Molecular Sciences”

 

q  Travel awards from Henry G. Friesen Chair in Endocrine and Metabolic Disorders, Canada, 2010

 

q  PNS Fellowship Award from the Peripheral Nerve Society, USA, 2009

 

q  Postgraduate Scholarship, The Ministry of Education, Youth and Sports, Czech Republic, 1st Medical Faculty, Charles University, Prague, 1997-2002                                                                

 

q  Scholarship for studies of M.D., The Ministry of Education, Youth and Sports, Czech Republic, 1st Medical Faculty, Charles University, Prague, 1991-1997

 

 

Grants

 

q  A two-year postdoctoral grant from the U.S. Army, Department of Defense, USA for the project "Role of mitochondria in prostate cancer". Total amount: 120,000 USD. 2004-2006

 

q  A three-year grant from the Grant Agency of Charles University, Prague, Czech Republic for the project "The function of mitochondrial glycerophosphate dehydrogenase in production of oxygen radicals".Total amount: 600,000 CZK. 1999-2001

 

 

Invited Lectures

 

q  16th European Bioenergetics Conference (EBEC 2010). Abnormalities of mitochondrial physiology and phenotype in sensory neurons in diabetes. Warsaw, Poland, July 17-22, 2010.

 

q  International Symposium on Diabetic Neuropathy (ISDN/Neurodiab). Impaired mitochondrial respiratory chain in dorsal root ganglia of streptozotocin-induced diabetic rats. Toronto, Ontario, Canada, October 15-18, 2009.

 

q  Biennial Meeting, The Peripheral Nerve society (PNS). Mitochondrial respiratory chain dysfunction of dorsal root ganglia in streptozotocin-induced diabetic rat and its correction by insulin treatment. Wurzburg, Germany, July 4-8, 2009.

 

q  Special invitation from the U.S. Army for the oral presentation “Role of mitochondrial glycerophosphate dehydrogenase in prostate cancer” at the conference "Innovative Minds in Prostate Cancer Today - IMPaCT", Atlanta, Georgia, USA, September 5-8, 2007.

 

q  5th Meeting of Canadian Oxidative Stress Consortium. Effects of oxidized or glycated low-density lipoproteins on mitochondrial function in porcine aortic endothelial cells. Montreal, Quebec, Canada, May 3-6, 2007.

 

 

Professional Affiliations

 

q  Society for Neuroscience, USA, 2011-present

 

q  Manitoba Neuroscience Network, Canada, 2010-present

 

q  Winnipeg Chapter Society for Neuroscience, Canada, 2009-present

 

q  Society for Free Radical Biology and Medicine, USA, 2009-present

 

q  Peripheral Nerve Society, USA, 2008-present

 

q  American Association for Cancer Research, USA, 2003-2006

 

q  Czech Society for Biochemistry and Molecular Biology, Czech Republic, 1999-2002

 

 

Peer Reviewed Publications

 

*indicates corresponding author

 

1.      *Roy Chowdhury SK, Dobrowsky RT, Fernyhough P. Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes. In press, Mitochondrion, July 2, 2011 (Epub ahead of print).

 

 

2.      *Roy Chowdhury SK , Smith DR, Schopansky J, Saleh A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P. Impaired AMP-activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and sensory neuropathy in diabetes. Submitted, Brain, 2011.

 

 

3.      Roy Chowdhury SK, Fernyhough P. Impaired mitochondrial bioenergetics in diabetic sensory neuropathy. In preparation (invited review, submission by October 31, 2011), Neurobiology of Disease, 2011.

 

 

4.      Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Akude E, Van der Ploeg R, Martens C, Mutch E, Glazner GW, Calcutt NA, Fernyhough P. Cytokines modulate an NF-kB-dependent signal transduction pathway that enhances neurite outgrowth in adult and that is impaired in diabetic sensory neuropathy. In preparation, Diabetes, 2011.

 

 

5.      Roy Chowdhury SK, Smith DR, Gomes S, Saleh A, Frizzie K, Kotra L, Calcutt NA, Fernyhough P. Altered AMPK, PGC1a and mitochondrial respiratory chain dysfunction in streptozotocin-induced diabetic rats/mice were prevented by certain drug treatment. In preparation, Nature Medicine, 2011.

 

 

6.      Akude E, Zherebitskaya E, Roy Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes, 60 (1), 1082-91, 2011.

 

 

7.      *Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes, 59 (4), 1082-91, 2010.

 

 

8.      Roy Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX. Effects of extensively oxidized low-density lipoproteins on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. American Journal of Physiology – Endocrinology and Metabolism, 298 (1), E89-98, 2010.

 

 

9.      Sangle GV, Chowdhury SK, Xie X, Stelmack GL, Halayko AJ, Shen GX. Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated LDL. Free Radical Biology and Medicine, 48 (6), 2010.

 

 

10.  Fernyhough P, Roy Chowdhury SK, Schmidt RE. Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Review of Endocrinology and Metabolism, 5(1): 39-49, 2010.

 

 

11.  Xie X, Chowdhury SR, Sangle GV, Shen GX. Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cell. Acta Biochimica Polonica, 57(4): 393-398, 2010.

 

 

12.  Akude E, Zherebitskaya E, Roy Chowdhury SK, Girling K, Fernyhough P. 4-hydroxy-2-noneal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy. Neurotoxicity Research, 17(1): 28-38, 2010.

 

 

13.  Chowdhury SK, Raha S, Tarnopolsky MA, Singh G. Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer. Free Radical Research, 41(10): 1116-1124, 2007.

 

 

14.  Chowdhury SK, Gemin A, Singh G. High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS generation in prostate cancer cell lines. Biochemical and Biophysical Research Communications, 333:1139-1145, 2005.

 

 

15.  Pecina P, Capkova M, Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstkova H, Zeman J, Godinot C, Houstek J. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome.  Biochimica et Biophysica acta, 1639(1): 53-63, 2003.

 

 

16.  Drahota Z, Chowdhury SK, Floryk D, Mracek T, Wilhelm J, Rauchova H, Lenaz G, Houstek J. Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide. Journal of Bioenergetics and Biomembranes, 34(2): 105-113, 2002.

 

 

17.  Williams Sion L, Taanman JW, Hansikova H, Houstkova H, Chowdhury SK, Zeman J, Houstek J. A novel mutation in SURF1 of a patient with cytochrome c oxidase deficient Leigh syndrome causes skipping of exon 8. Molecular Genetics and Metabolism, 73(4): 340-343, 2001.

 

 

18.  Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J. Activities of mitochondrial oxidative phosphorylation in cultured amniocytes. Clinica Chimica Acta, 298(1-2): 157-173, 2000.

 

 

19.  Houstek J, Klement P, Floryk D, Antonicka H, Hermanska J, Kalous M, Hansikova H, Houstkova H,  Chowdhury SK, Rosipal S, Kmoch S, Stratilova L, Zeman J. A novel deficiency of mitochondrial ATPase of nuclear origin. Human Molecular Genetics, 8(11): 167-174, 1999.

 

 

Abstracts

 

 

1.      Roy Chowdhury SK, Saleh A, Schapansky J, Smith DR, Gomes S, and Fernyhough P. Impaired AMPK/ PGC-1 is linked to mitochondrial dysfunction and sensory neuropathy in diabetes. 21st Annual Meeting of Neurodiab, Porto, Portugal, September 7-11, 2011.

 

 

2.      Smith DR, Roy Chowdhury SK, Frizzie K, Kotra L, Calcutt NA, and Fernyhough P. Muscarinic receptor antagonism corrects deficits in mitochondrial protein expression and function in dorsal root ganglia tissue of streptozotocin-induced diabetic rodents. 21st Annual Meeting of Neurodiab, Porto, Portugal, September 7-11, 2011.

 

 

3.      Roy Chowdhury SK, Raha S, Tarnopolsky MA, and Singh G. The role of mitochondrial glycerophosphate dehydrogenase in prostate cancer. "Innovative Minds in Prostate Cancer Today - IMPaCT", Orlando, Florida, USA, March 9-11, 2011.

 

 

4.      Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Aberrant mitochondrial proteome expression and physiology in sensory neurons in diabetic neuropathy. 20th Annual Meeting of Neurodiab, Stockholm, Sweden, September 17-19, 2010.

 

 

5.      Akude E, Roy Chowdhury SK, Zherebitskaya E, and Fernyhough P. Mitochondria in the axons of type 1 diabetic rats exhibit aberrant physiology and reduced respiratory chain-dependent ROS generation. 20th Annual Meeting of Neurodiab, Stockholm, Sweden, September 17-19, 2010.

 

 

6.      Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Abnormalities of mitochondrial physiology and phenotype in sensory neurons in diabetes. 16th European Bioenergetics Conference (EBEC 2010 - selected for oral presentation), Warsaw, Poland, July 17-22, 2010. Biochimica et Biophysica Acta, Suppl. (1797), 76, 2010.

 

 

7.      Roy Chowdhury SK, Xie X, Sangle GV, Shen GX. Impact of diabetes-associated lipoproteins on oxygen consumption, enzymatic activities of mitochondrial respiratory chain complexes. 16th European Bioenergetics Conference, Warsaw, Poland, July 17-22, 2010. Biochimica et Biophysica Acta, Suppl. (1797), 53, 2010.

 

 

8.      Akude E, Roy Chowdhury SK, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Diabetes induces aberrant mitochondrial physiology and phenotype in sensory neurons: relevance to oxidative stress and associated neurodegeneration. Physiology 2010, Manchester, England, June 30-July 2, 2010.

 

 

9.      Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Mitochondrial respiratory chain dysfunction of dorsal root ganglia in type 1 diabetic rats is the result of down-regulation of the mitochondrial proteome. Annual Canadian Neuroscience Meeting, Ottawa, Ontario, Canada, May 15-18, 2010.

 

 

10.  Zhao R, Sangle GV, Roy Chowdhury SK, and Shen GX. Mechanism for oxidized and glycated LDL-induced oxidative stress in vascular endothelial cells: role of mitochondrial dysfunction and NADPH oxidase. Arteriosc Thromb Vasc Biol 2010 Scientific Sessions, P76, 2010.

 

 

11.  Roy Chowdhury SK, Zherebitskaya E, Smith DR, and Fernyhough P. Impaired mitochondrial respiratory chain in dorsal root ganglia of streptozotocin-induced diabetic rats. International Symposium on Diabetic Neuropathy (ISDN/Neurodiab - selected for oral presentation), Toronto, Ontario, Canada, October 15-18, 2009.

 

                                                                                                                                                                                 

 

12.  Akude E, Zherebitskaya E, Roy Chowdhury SK, and Fernyhough P. Lipid peroxidation product-dependent alteration of mitochondrial activity and inhibition of axonal outgrowth in sensory neurons isolated from streptozotocin diabetic rats. International Symposium on Diabetic Neuropathy (ISDN/Neurodiab), Toronto, Ontario, Canada, October 15-18, 2009.

 

 

13.  Roy Chowdhury SK, Smith DR, and Fernyhough P. Mitochondrial respiratory chain dysfunction of dorsal root ganglia in streptozotocin-induced diabetic rat and its correction by insulin treatment (selected for oral presentation). Biennial Meeting, The Peripheral Nerve society, Wurzburg, Germany, July 4-8, 2009.

 

 

14.  Akude E, Zherebitskaya E, Roy Chowdhury SK, and Fernyhough P. 4-Hydroxy-2-noneal modifies mitochondrial proteins, impairs mitochondrial activity and causes suboptimal axonal outgrowth in cultured adult sensory neurons. Biennial Meeting, The Peripheral Nerve society, Wurzburg, Germany, July 4-8, 2009.

 

 

15.  Fernyhough P, Akude E, Roy Chowdhury SK, Smith DR, and Zherebitskaya E. Mitochondrial stress and the pathogenesis of diabetic neuropathy. Complications of diabetes and obesity, Vancouver, British Columbia, Canada, February 24 – March 1, 2009.

 

 

16.  Sangle GV, Roy Chowdhury SK, Xie X, and Shen GX. Impairment of electron transport chain activity in mitochondria of endothelial cells induced by glycated LDL. 6th Meeting of Canadian Oxidative Stress Consortium, Winnipeg, Manitoba, Canada, P89, 2009.

 

 

17.  Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial respiratory chain activity and enzymes in arterial endothelial cells. Atherosclerosis, 10 (suppl. P275), 2009.

 

 

18.  Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Canadian lipoprotein conference, P42, 2009.

 

 

19.  Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial respiration chain activity and enzymes in arterial endothelial cells. International Diabetes Federation, Canadian Journal of Diabetes, 33:231, 2009.

 

                                                                                                                                                              

 

20.  Roy Chowdhury SK, and Shen GX. Effects of oxidized or glycated low-density lipoproteins on mitochondrial function in porcine aortic endothelial cells (selected for oral presentation). 5th Meeting of Canadian Oxidative Stress Consortium, Montreal, Quebec, Canada, May 3-6, 2007.

 

 

21.  Roy Chowdhury SK, Raha S, Tarnopolsky MA, and Singh G. Role of mitochondrial glycerophosphate dehydrogenase in prostate cancer (selected for oral presentation). "Innovative Minds in Prostate Cancer Today - IMPaCT", Atlanta, Georgia, USA, September 5-8, 2007.

 

 

22.  Roy Chowdhury SK, and Shen GX. Effects of oxidized or glycated low-density lipoproteins on mitochondrial function in porcine aortic endothelial cells (selected for oral presentation). 5th Meeting of Canadian Oxidative Stress Consortium, Montreal, Quebec, Canada, May 3-6, 2007.

 

 

23.  Roy Chowdhury SK, and Shen GX. Alterations in mitochondrial function in vascular endothelial cells exposed to oxidized or glycated LDL, Canadian Journal of Diabetes, 31:290, 2007.

 

 

24.  Roy Chowdhury SK, and Shen GX. Attenuated activities of mitochondria function in vascular endothelial cells exposed to oxidized or glycated low density lipoproteins, Circulation, 116II:81, 2007.

 

 

25.  Roy Chowdhury SK, and Singh G. Role of mitochondrial glycerophosphate dehydrogenase in prostate cancer cells. 95th Annual Meeting of AACR (American association for Cancer Research), Orlando, Florida, USA, March 27-31, 2004.

 

 

26.  Wang HP, Roy Chowdhury SK, Esspiritu M, Rainbow AJ, and Singh G. Activation of nuclear factor kappa B in hypoxia-resistant prostate tumor cells. 94th Annual Meeting of AACR (American association for Cancer Research), Washington, D.C., USA, July 11-14, 2003.

 

 

27.  Roy Chowdhury SK, Vojtiskova A, Drahota Z, and Houstek J. Evaluation of mitochondrial oxidative capacity in cultured amniocytes and fibroblasts. 27th International Meeting of the Federation of European Biochemical societies (FEBS) Lisbon, Portugal, June 30 – July 5, 2001. European Journal of Biochemistry, 268 (Suppl I), 141, 2001.

 

 

28.  Roy Chowdhury SK, Drahota Z, Vojtiskova A, Pecina P, Hansikova H, Zeman J, and Houstek J.Functional alteration of cytochrome c oxidase (COX) by SURF1 mutations. 39th Annual Symposium of SSIEM (Society for the study of Inborn errors of Metabolism), Prague, Czech Republic, September 7-9, 2001. Journal of Inherited Metabolic Diseases, 24 (suppl. 1), 82, 2001.

 

 

29.  Roy Chowdhury SK, Drahota Z, Vojtiskova A, Pecina P, Capkova M, Hansikova H, Houstkova H, Zeman J, and Houstek J. Changes of cytochrome c oxidase induced by SURF1 mutation in cultured fibroblasts. 5th European Meeting on Mitochondrial Pathology, Venice, Italy, September 19-23, 2001. Mitochondrion, 1 (suppl.1), 38, 2001.

 

 

30.   Drahota Z, Roy Chowdhury SK, Floryk D, Mracek T, Wilhelm J, Rauchova H, Lenaz G, and Houstek J. Mitochondrial Glycerophosphate dehydrogenase (mGPDH) is an active site of hydrogen peroxide production in mammalian mitochondria. 5th European Meeting on Mitochondrial Pathology, Venice, Italy, September 19-23, 2001. Mitochondrion, 1 (suppl.1), 44, 2001.

 

 

31.  Lapathitis G, Mracek T, Roy Chowdhury SK, Sebesta O, Houstek J, and Motlik J. Effect of butyrolactone I on the function and distribution in human skin fibroblasts. 5th European Meeting on Mitochondrial Pathology, Venice, Italy, September 19-23, 2001. Mitochondrion, 1 (suppl.1), 59, 2001.

 

 

32.  Houstek J, Klement P, Antonicka H, Kaplanova V,Pickova A, Paul J, Sebesta O, Hansikova H, Houstkova H, Roy Chowdhury SK,and Zeman J. Specific defects of mitochondrial ATPase due to alteration of enzyme assembly. 5th European Meeting on Mitochondrial Pathology, Venice, Italy, September 19-23, 2001.  Mitochondrion. 1(2), 307, 2001.

 

 

33.   Roy Chowdhury SK, Drahota Z, and Houstek J. Evaluation of mitochondrial function in cultured amniocytes. 2nd Colloquium on Mitochondria and Myopathies, Halle, Germany, March 31- April 2, 2000. European Journal of Medical Research, 5 (Suppl I), 51, 2000.

 

 

34.  Houstek J, Klement P, Floryk D, Antonicka H, Stratilova L, Hermanska J, Kalous M, Hansikova H, Houstkova H, Roy Chowdhury SK, Rosipal S, Kmoch S, and Zeman J. A novel deficiency of mitochondrial ATPase of nuclear origin. 2nd Colloquium on Mitochondria and Myopathies, Halle, Germany, March 31- April 2, 2000. European Journal of Medical Research, 5 (Suppl I), 51, 2000.

 

 

35.  Roy Chowdhury SK, Drahota Z, and Houstek J. Evaluation of mitochondrial enzymes in amniocytes. 6th Meeting of Czech and Slovak Societies for Physiology, Hradec Kralove, Czech Republic, February 2-4, 2000. Physiological Research, 49 (Issue 4), P29, 2000.

 

 

36.  Roy Chowdhury SK, Drahota Z, and Houstek J. Mitochondrial respiratory enzyme activities in human fetal cells. 17th Biochemical Congress of Czech and Slovak Societies for Biochemistry and Molecular Biology, Prague, Czech Republic, September 7-9, 2000. Chem. Listy, 94, 620, 2000.

 

 

37.  Drahota Z, Roy Chowdhury SK, and Houstek J. The role of cytochrome c oxidase in regulation of cell energy metabolism. 17th Biochemical Congress of Czech and Slovak Societies for Biochemistry and Molecular Biology, Prague, Czech Republic, September 7-9, 2000. Chem. Listy, 94, 619, 2000.

 

 

38.  Houstek J, Klement P, Floryk D, Antonicka H, Stratilova L, Hermanska J, Kalous M, Hansikova H, Houstkova H, Roy Chowdhury SK, Rosipal S, Kmoch S, and Zeman J. Genetic defects of mitochondrial ATPase synthase. 17th Biochemical Congress of Czech and Slovak Societies for Biochemistry and Molecular Biology, Prague, Czech Republic, September 7-9, 2000. Chem. Listy, 94, 620, 2000.

 

 

39.  Stieglerova A, Roy Chowdhury SK, Drahota Z, Rauchova H, Ostadal B, and Houstek J. Optimal conditions for determination of maximum cytochrome c oxidase activity in the rat heart and brain. World Congress of International Association for Heart Research, Prague, Czech Republic, July 2-4, 1999. Physiological Research, 48 (Suppl I), 123, 1999.

 

 

Other Personal Data

 

Canadian Citizen

 

 

References

 

Provide upon request