Subir K. Roy Chowdhury, M.D., Ph.D.
302 Mandalay Drive, Winnipeg MB R2P 1K2 CANADA
skr_chowdhury@yahoo.ca Tel: 204-235-3574 (office), 204-221-6951 (home) &
204-995-6183 (cell)
Supplementary training, Courses and Workshops
q Postgraduate Scholarship, The Ministry of Education, Youth and Sports, Czech Republic, 1st Medical Faculty, Charles University, Prague, 1997-2002
1. *Roy Chowdhury SK, Dobrowsky RT, Fernyhough P. Nutrient excess and altered mitochondrial proteome and function contribute to neurodegeneration in diabetes. In press, Mitochondrion, July 2, 2011 (Epub ahead of print).
2. *Roy Chowdhury SK , Smith DR, Schopansky J, Saleh A, Gomes S, Akude E, Morrow D, Calcutt NA, Fernyhough P. Impaired AMP-activated protein kinase signaling in dorsal root ganglia neurons is linked to mitochondrial dysfunction and sensory neuropathy in diabetes. Submitted, Brain, 2011.
3. Roy Chowdhury SK, Fernyhough P. Impaired mitochondrial bioenergetics in diabetic sensory neuropathy. In preparation (invited review, submission by October 31, 2011), Neurobiology of Disease, 2011.
4. Saleh A, Roy Chowdhury SK, Smith DR, Balakrishnan S, Akude E, Van der Ploeg R, Martens C, Mutch E, Glazner GW, Calcutt NA, Fernyhough P. Cytokines modulate an NF-kB-dependent signal transduction pathway that enhances neurite outgrowth in adult and that is impaired in diabetic sensory neuropathy. In preparation, Diabetes, 2011.
5. Roy Chowdhury SK, Smith DR, Gomes S, Saleh A, Frizzie K, Kotra L, Calcutt NA, Fernyhough P. Altered AMPK, PGC1a and mitochondrial respiratory chain dysfunction in streptozotocin-induced diabetic rats/mice were prevented by certain drug treatment. In preparation, Nature Medicine, 2011.
6. Akude E, Zherebitskaya E, Roy Chowdhury SK, Smith DR, Dobrowsky RT, Fernyhough P. Diminished superoxide generation is associated with respiratory chain dysfunction and changes in the mitochondrial proteome of sensory neurons from diabetic rats. Diabetes, 60 (1), 1082-91, 2011.
7. *Chowdhury SK, Zherebitskaya E, Smith DR, Akude E, Chattopadhyay S, Jolivalt CG, Calcutt NA, Fernyhough P. Mitochondrial respiratory chain dysfunction in dorsal root ganglia of streptozotocin-induced diabetic rats and its correction by insulin treatment. Diabetes, 59 (4), 1082-91, 2010.
8. Roy Chowdhury SK, Sangle GV, Xie X, Stelmack GL, Halayko AJ, Shen GX. Effects of extensively oxidized low-density lipoproteins on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. American Journal of Physiology – Endocrinology and Metabolism, 298 (1), E89-98, 2010.
9. Sangle GV, Chowdhury SK, Xie X, Stelmack GL, Halayko AJ, Shen GX. Impairment of mitochondrial respiratory chain activity in aortic endothelial cells induced by glycated LDL. Free Radical Biology and Medicine, 48 (6), 2010.
10. Fernyhough P, Roy Chowdhury SK, Schmidt RE. Mitochondrial stress and the pathogenesis of diabetic neuropathy. Expert Review of Endocrinology and Metabolism, 5(1): 39-49, 2010.
11. Xie X, Chowdhury SR, Sangle GV, Shen GX. Impact of diabetes-associated lipoproteins on oxygen consumption and mitochondrial enzymes in porcine aortic endothelial cell. Acta Biochimica Polonica, 57(4): 393-398, 2010.
12. Akude E, Zherebitskaya E, Roy Chowdhury SK, Girling K, Fernyhough P. 4-hydroxy-2-noneal induces mitochondrial dysfunction and aberrant axonal outgrowth in adult sensory neurons that mimics features of diabetic neuropathy. Neurotoxicity Research, 17(1): 28-38, 2010.
13. Chowdhury SK, Raha S, Tarnopolsky MA, Singh G. Increased expression of mitochondrial glycerophosphate dehydrogenase and antioxidant enzymes in prostate cancer cell lines/cancer. Free Radical Research, 41(10): 1116-1124, 2007.
14. Chowdhury SK, Gemin A, Singh G. High activity of mitochondrial glycerophosphate dehydrogenase and glycerophosphate-dependent ROS generation in prostate cancer cell lines. Biochemical and Biophysical Research Communications, 333:1139-1145, 2005.
15. Pecina P, Capkova M, Chowdhury SK, Drahota Z, Dubot A, Vojtiskova A, Hansikova H, Houstkova H, Zeman J, Godinot C, Houstek J. Functional alteration of cytochrome c oxidase by SURF1 mutations in Leigh syndrome. Biochimica et Biophysica acta, 1639(1): 53-63, 2003.
16. Drahota Z, Chowdhury SK, Floryk D, Mracek T, Wilhelm J, Rauchova H, Lenaz G, Houstek J. Glycerophosphate-dependent hydrogen peroxide production by brown adipose tissue mitochondria and its activation by ferricyanide. Journal of Bioenergetics and Biomembranes, 34(2): 105-113, 2002.
17. Williams Sion L, Taanman JW, Hansikova H, Houstkova H, Chowdhury SK, Zeman J, Houstek J. A novel mutation in SURF1 of a patient with cytochrome c oxidase deficient Leigh syndrome causes skipping of exon 8. Molecular Genetics and Metabolism, 73(4): 340-343, 2001.
18. Chowdhury SK, Drahota Z, Floryk D, Calda P, Houstek J. Activities of mitochondrial oxidative phosphorylation in cultured amniocytes. Clinica Chimica Acta, 298(1-2): 157-173, 2000.
19. Houstek J, Klement P, Floryk D, Antonicka H, Hermanska J, Kalous M, Hansikova H, Houstkova H, Chowdhury SK, Rosipal S, Kmoch S, Stratilova L, Zeman J. A novel deficiency of mitochondrial ATPase of nuclear origin. Human Molecular Genetics, 8(11): 167-174, 1999.
1. Roy Chowdhury SK, Saleh A, Schapansky J, Smith DR, Gomes S, and Fernyhough P. Impaired AMPK/ PGC-1 is linked to mitochondrial dysfunction and sensory neuropathy in diabetes. 21st Annual Meeting of Neurodiab, Porto, Portugal, September 7-11, 2011.
2. Smith DR, Roy Chowdhury SK, Frizzie K, Kotra L, Calcutt NA, and Fernyhough P. Muscarinic receptor antagonism corrects deficits in mitochondrial protein expression and function in dorsal root ganglia tissue of streptozotocin-induced diabetic rodents. 21st Annual Meeting of Neurodiab, Porto, Portugal, September 7-11, 2011.
3. Roy Chowdhury SK, Raha S, Tarnopolsky MA, and Singh G. The role of mitochondrial glycerophosphate dehydrogenase in prostate cancer. "Innovative Minds in Prostate Cancer Today - IMPaCT", Orlando, Florida, USA, March 9-11, 2011.
4. Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Aberrant mitochondrial proteome expression and physiology in sensory neurons in diabetic neuropathy. 20th Annual Meeting of Neurodiab, Stockholm, Sweden, September 17-19, 2010.
5. Akude E, Roy Chowdhury SK, Zherebitskaya E, and Fernyhough P. Mitochondria in the axons of type 1 diabetic rats exhibit aberrant physiology and reduced respiratory chain-dependent ROS generation. 20th Annual Meeting of Neurodiab, Stockholm, Sweden, September 17-19, 2010.
6. Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Abnormalities of mitochondrial physiology and phenotype in sensory neurons in diabetes. 16th European Bioenergetics Conference (EBEC 2010 - selected for oral presentation), Warsaw, Poland, July 17-22, 2010. Biochimica et Biophysica Acta, Suppl. (1797), 76, 2010.
7. Roy Chowdhury SK, Xie X, Sangle GV, Shen GX. Impact of diabetes-associated lipoproteins on oxygen consumption, enzymatic activities of mitochondrial respiratory chain complexes. 16th European Bioenergetics Conference, Warsaw, Poland, July 17-22, 2010. Biochimica et Biophysica Acta, Suppl. (1797), 53, 2010.
8. Akude E, Roy Chowdhury SK, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Diabetes induces aberrant mitochondrial physiology and phenotype in sensory neurons: relevance to oxidative stress and associated neurodegeneration. Physiology 2010, Manchester, England, June 30-July 2, 2010.
9. Roy Chowdhury SK, Akude E, Zherebitskaya E, Smith DR, Dobrowsky R, and Fernyhough P. Mitochondrial respiratory chain dysfunction of dorsal root ganglia in type 1 diabetic rats is the result of down-regulation of the mitochondrial proteome. Annual Canadian Neuroscience Meeting, Ottawa, Ontario, Canada, May 15-18, 2010.
10. Zhao R, Sangle GV, Roy Chowdhury SK, and Shen GX. Mechanism for oxidized and glycated LDL-induced oxidative stress in vascular endothelial cells: role of mitochondrial dysfunction and NADPH oxidase. Arteriosc Thromb Vasc Biol 2010 Scientific Sessions, P76, 2010.
11. Roy Chowdhury SK, Zherebitskaya E, Smith DR, and Fernyhough P. Impaired mitochondrial respiratory chain in dorsal root ganglia of streptozotocin-induced diabetic rats. International Symposium on Diabetic Neuropathy (ISDN/Neurodiab - selected for oral presentation), Toronto, Ontario, Canada, October 15-18, 2009.
12. Akude E, Zherebitskaya E, Roy Chowdhury SK, and Fernyhough P. Lipid peroxidation product-dependent alteration of mitochondrial activity and inhibition of axonal outgrowth in sensory neurons isolated from streptozotocin diabetic rats. International Symposium on Diabetic Neuropathy (ISDN/Neurodiab), Toronto, Ontario, Canada, October 15-18, 2009.
13. Roy Chowdhury SK, Smith DR, and Fernyhough P. Mitochondrial respiratory chain dysfunction of dorsal root ganglia in streptozotocin-induced diabetic rat and its correction by insulin treatment (selected for oral presentation). Biennial Meeting, The Peripheral Nerve society, Wurzburg, Germany, July 4-8, 2009.
14. Akude E, Zherebitskaya E, Roy Chowdhury SK, and Fernyhough P. 4-Hydroxy-2-noneal modifies mitochondrial proteins, impairs mitochondrial activity and causes suboptimal axonal outgrowth in cultured adult sensory neurons. Biennial Meeting, The Peripheral Nerve society, Wurzburg, Germany, July 4-8, 2009.
15. Fernyhough P, Akude E, Roy Chowdhury SK, Smith DR, and Zherebitskaya E. Mitochondrial stress and the pathogenesis of diabetic neuropathy. Complications of diabetes and obesity, Vancouver, British Columbia, Canada, February 24 – March 1, 2009.
16. Sangle GV, Roy Chowdhury SK, Xie X, and Shen GX. Impairment of electron transport chain activity in mitochondria of endothelial cells induced by glycated LDL. 6th Meeting of Canadian Oxidative Stress Consortium, Winnipeg, Manitoba, Canada, P89, 2009.
17. Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial respiratory chain activity and enzymes in arterial endothelial cells. Atherosclerosis, 10 (suppl. P275), 2009.
18. Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial function and reactive oxygen species in porcine aortic endothelial cells. Canadian lipoprotein conference, P42, 2009.
19. Roy Chowdhury SK, Sangle GV, Xie X, and Shen GX. Effect of oxidized and glycated LDL on mitochondrial respiration chain activity and enzymes in arterial endothelial cells. International Diabetes Federation, Canadian Journal of Diabetes, 33:231, 2009.
20. Roy Chowdhury SK, and Shen GX. Effects of oxidized or glycated low-density lipoproteins on mitochondrial function in porcine aortic endothelial cells (selected for oral presentation). 5th Meeting of Canadian Oxidative Stress Consortium, Montreal, Quebec, Canada, May 3-6, 2007.
21. Roy Chowdhury SK, Raha S, Tarnopolsky MA, and Singh G. Role of mitochondrial glycerophosphate dehydrogenase in prostate cancer (selected for oral presentation). "Innovative Minds in Prostate Cancer Today - IMPaCT", Atlanta, Georgia, USA, September 5-8, 2007.
22. Roy Chowdhury SK, and Shen GX. Effects of oxidized or glycated low-density lipoproteins on mitochondrial function in porcine aortic endothelial cells (selected for oral presentation). 5th Meeting of Canadian Oxidative Stress Consortium, Montreal, Quebec, Canada, May 3-6, 2007.
23. Roy Chowdhury SK, and Shen GX. Alterations in mitochondrial function in vascular endothelial cells exposed to oxidized or glycated LDL, Canadian Journal of Diabetes, 31:290, 2007.
24. Roy Chowdhury SK, and Shen GX. Attenuated activities of mitochondria function in vascular endothelial cells exposed to oxidized or glycated low density lipoproteins, Circulation, 116II:81, 2007.
Provide upon request