Intersections from west to east:

US52 joins IL251 south near Mendota

<251>

US34 in Mendota

<34>

US52 breaks off of IL251 to head easterly again

I-39/US51 near Troy Grove

Signage on US52 eastbound at I-39/US51

IL23 joins from the south in rural LaSalle County

IL23 splits off to the north again shortly after

IL71 near Serena

IL47 near Lisbon

It passes through these towns: Mendota, Troy Grove, Serena, Lisbon.