| Item | Description |
| Antidote | Cures Poison |
| Awakening | Cures Sleep |
| Bicycle | Allows you to travel faster |
| Bike Voucher | Used to buy a bike |
| Burn Heal | Used to heal burn |
| Calcium | Boosts Special rating |
| Carbos | Boosts Speed rating |
| Card Key | Opens Silph Co. doors |
| Coin | Used to play slot machines |
| Coin Case | Holds coins |
| Dire Hit | Boosts attack effectiveness |
| Dome Fossil | Used to clone new Pokémon (Kabuto) |
| Elixer | Gives 10 PP to all abilities |
| Escape Rope | Used to escape current area |
| Ether | Gives 10 PP to one ability |
| Exp. All | In battle, allows experience points to be divided to all Pokémon |
| Fire Stone | Triggers Evolution of some Fire Pokémon |
| Fresh Water | Quenches thirst, restores 50 HP |
| Full Heal | Cures any condition |
| Full Restore | Cures, restores all HP |
| Gold Teeth | Helps Warden in Fushia City speak |
| Good Rod | Used to fish for Pokémon |
| Great Ball | Used to catch wild Pokémon |
| Guard Spec. | Disables Special Attacks |
| Helix Fossil | Used to clone new Pokémon (Omanyte) |
| HP Up | Boosts HP meter by one point |
| Hyper Potion | Restores 200 HP |
| Ice Heal | Thaws frozen Pokémon |
| Iron | Boosts Defense rating |
| Item Finder | Exposes hidden items |
| Leaf Stone | Triggers Evolution of some plant Pokémon |
| Lemonade | Quenches thirst, restores 80 HP |
| Lift Key | Activates elevator |
| Master Ball | Only Ball that catches Pokémon 100% of the time |
| Max Elixer | Restores all PP |
| Max Ether | Restores all PP to one ability |
| Max Potion | Restores all HP |
| Max Repel | Prevents random attacks |
| Max Revive | Revives fainted Pokémon, restores all HP |
| Moon Stone | Triggers evolution of some Moon Pokémon |
| Nugget | Can be sold for $5,000 |
| Oak's Parcel | Belongs to Professor Oak |
| Old Amber | Used to clone new Pokémon (Aerodactyl) |
| Old Rod | Used to fish for Pokémon |
| Paralyze Heal | Cures Paralysis |
| Poké Ball | Used to catch wild Pokémon |
| Poké Doll | Distracts opponent |
| Poké Flute | Wakes sleeping Pokémon |
| Pokédex | Used to store Pokémon data |
| Potion | Restores 20 HP |
| PP Up | Boosts PP Meter by one point |
| Protein | Boosts Attack rating |
| Rare Candy | Boosts experience level by one |
| Repel | Prevents Random attacks |
| Revive | Revives fainted Pokémon |
| S.S. Ticket | Used to board the S.S Anne |
| Safari Ball | Used to catch wild Pokémon in the Safari Zone |
| Secret Key | Opens Cinnabar Island Gym |
| Silph Scope | Used to identify Ghost Pokémon |
| Soda Pop | Quenches thirst, restores 60 HP |
| Super Potion | Restores 50 HP |
| Super Repek | Prevents random attacks |
| Super Rod | Used to fish for Pokémon |
| Thunder Stone | Triggers evolution of some Electric Pokémon |
| Town Map | Map of the entire game |
| Ultra Ball | Used to catch wild Pokémon |
| Water Stone | Triggers evolution for some Water Pokémon |
| X Accuracy | Boosts Accuracy temporarily |
| X Attack | Boosts Attack temporarily |
| X Defend | Boosts Defense temporarily |
| X Special | Boosts Special temporarily |
| X Speed | Boosts Speed temporarily |
