Q. Hi. I started taking Lamictal on Friday and want to know about the rash that sometimes come with it. What is it like and how will I know if I am getting it. I have eczema already and am scared I won't be able to tell. My psychiatrist told me to report any rash at all, but with the eczema and other allergies I always seem to have some kind of rash. Thanks, Mark.

A. Dear Mark,

Stevens Johnson Syndrome (SJS) is a very severe form of erythema multiforme that affects the skin and mucous membranes. The rash often appears similar to chickenpox and sometimes blisters. Sores also develop in the mucous membranes including the eyes, mouth, nose, and vagina. Fever and pain is very common. This reaction can be life threatening, and if you suspect you may be devloping it you should immediately discontinue the medication and contact your doctor.

Allergy to medication is a common cause of SJS, and Lamictal is a medication known to induce it. Children are at greater risk than adults. Symptoms generally begin before the 8th week after starting Lamictal. To decrease risk, the medication dose should be very gradually increased over time.

For more information, I suggest you visit the Stevens Johnson Syndrome Foundation.

Anna