Gator Football Schedule 1981
| Opponent | Date | Location | Score |
| Ball State | 2 Sep 2000 | Gainesville | |
| Middle Tennessee State | 9 Sep 2000 | Gainesville | |
| Tennessee | 16 Sep 2000 | Knoxville | |
| Kentucky | 23 Sep 2000 | Gainesville | |
| Mississippi State | 30 Sep 2000 | Starkville | |
| LSU | 7 Oct 2000 | Gainesville | |
| Auburn | 14 Oct 2000 | Gainesville | |
| Georgia | 28 Oct 2000 | Jacksonville | |
| Vanderbilt | 4 Nov 2000 | Nashville | |
| South Carolina | 11 Nov 2000 | Gainesville | |
| Florida State | 18 Nov 2000 | Tallahassee | |
| SEC Championship Game | 2 Dec 2000 | Atlanta, Georgia | |
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