The portly Wade is content living with his roommate Brian and watching television, playing video games, and showing off his Huge Arse Crack! But when Brian's girlfriend refuses to move in because of Wade's penchant for baggy pants, Brian decides he has no choice... He must kill Wade. After the funeral, Wade's vengeful voodoo sister zombifies his ass, as well as the rest of his body, to terrorize Brian. But Brian counterattacks and enlists the spiritual aid of the bible-banging Preacher Man Bob to help ward off the evil undead BUTTCRACK.