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When C.E.O. Ozzy Osborn of Oscorp became President of the United States of America, he created a regime that rooted out subversion and weakness. Oscorp created the Variable Engagement Neuro-sensitive Organic Mesh (or V.E.N.O.M.) to empower Ozzy's brutal police force known as the Thunderbolt Department.

Elsewhere, punk-rocker Hobie Brown developed spider-powers due to illegal chemical dumping. He was able to create the Spider Army and fought against Osborn, who eventually fell in battle with them.

Captain Anarchy
The Hulk
M.C. Strange

Norman Osborn
Adrian Toomes
Kang the Conglomerator

Villainous Groups:
Thunderbolt Department
Toomestone Records
Annihilation Wave
The U-Foes
The Universal Church of Truth