ACT 1: It is midday in New York City. People are out and about when suddenly a loud humming noise makes itself heard. The source of the humming, an exquisitely beautiful woman clad in a stunning black dress, emerges from a dark limousine. Meanwhile, at the Parker's homestead, Mary Jane is enjoying an 8-hour marathon of the world's most revolting crime scenes on the Detective Channel while Peter heads into the bathroom to wash up. As he washes his hands, his nose and ears start bleeding and he falls to the floor; pain seeping through his body. Startled, MJ rushes over to his side. Peter tells her that his spider-sense is going ballistic like he's never felt before. Meanwhile, on the rooftop of a nearby building, Captain America stands tall, looking out towards the horizon. A chopper suddenly appears, hovering a few feet away. Onboard the chopper is Nick Fury, colonel of S.H.I.E.L.D. He simply tells Cap that S.H.I.E.L.D. could really used his help.

ACT 2: Meanwhile, the stunningly beautiful woman seen earlier seems to now have a herd of followers who do her every bidding, from simply hurting bystanders to killing cops and whomever stands in her way. Accompanied by her newfound supporters, she makes her way to the rooftop of a nearby building. In the mean time, Spider-Man has made his way to the commotion, guided by his trusty spider-sense. Minutes after arriving at the aforementioned building, he is joined by Captain America who parachutes down to the location courtesy of S.H.I.E.L.D.. After coming up with some semblance of a plan, the two heroes make their way to the rooftop. A police chopper present at the scene tries to negotiate with the woman but she sends it into a tailspin and it begins falling down towards the concrete pavement. In a stroke of luck, the chopper somehow immobilizes itself when it smashes into the side of the building and the tangled heap of metal holds it in place there. Spider-Man, who had been climbing up the side of the building, finally reaches the rooftop, where the woman and her followers are hanging around, seemingly waiting for something or someone. Spider-Man confronts the woman but she is revealed to be a lot more powerful than he had thought. He tries his best to overpower her but ends up struggling to even land a solid punch. Captain America, who has now reached the rooftop by taking the stairs, yells at Spider-Man to back away from her while he struggles to fight off the woman's followers. Spider-Man does just that. However, the woman suddenly emits a scream that sends him crashing to the ground, nose and ears bleeding once again. Two of the followers grab Spider-Man and they stand him upright, facing the woman. As she pulls his mask halfway up his face, Captain America manages to send his shield flying towards the woman. However, one of the followers leaps to protect his "queen" and takes the shield in the chest. The woman turns around and faces Captain America, whom she seems to recognize. Cap calls her "Ana" and tells her to surrender now and no lives will be lost. Using her extraordinary powers, Ana uses a dozen of her followers as projectiles and sends them flying in the air towards Captain America. Cap averts being struck by some of the flying bodies but is not quick enough to prevent from being hit by his shield, which Ana has thrown back in his direction. With one swift quick in the face, Ana renders Captain America unconscious, while Spider-Man struggles to free himself from Ana's followers, who are holding him down. Screaming once again, Ana renders Spider-Man unconscious as well. With his mask still halfway up his face, Ana begins kissing a bloody Spider-Man.