The last hallucinatory mists of the Mysterio trio had barely faded when Spider-Man made one of the biggest decisions in his life and turned against Tony Stark, a.k.a. Iron Man, and the United States government. And by joining Captain America's rebellion against the Superhuman Registration Act while is secret identity is already revealed to the world, Peter has put himself and his loved ones in a dangerous position – they are now fugitives from justice and prime targets for the government and its shadowy conspirators.

Meanwhile, school nurse Miss Arrow has her own plan for Peter Parker and it involves keeping him at Midtown High. She has already demonstrated the shocking ability to produce spikes from her wrists, but what else does she have up her sleeve?

ACT 1: The story opens at the home of Deborah Whitman, one time girlfriend of Peter Parker. Deb, as she is referred to, is on the phone with Alex, the man with whom she is collaborating on a tell-all book about Peter. Deb tells Alex she is concerned with the title of the book – "Two-Faced – How Peter Parker ruined my life" and the fact that her manuscript has been altered, giving the book a totally different tone. Alex replies by explaining that the publisher felt it needed punching up and tells her that they can further discuss the book when she comes to New York City for a book signing; he then hangs up. Furious, Deb throws a nearby pile of books to the ground. Deb's mother, who is upstairs, calls for her and asks if everything is all right. Deb responds that everything is fine and her mother answers back, offering words of advice.

ACT 2: In New York City, outside Midtown High School, a small white van pulls over in a no-parking zone and three armed men wearing ski masks spring out its side door. The trio immediately head for the school – seemingly there to attack Peter – only to be stopped in their tracks by none other than Wolverine. The feisty X-Men recaps the details of their flawed plan – in the process revealing that J. Jonah Jameson is offering a cash reward for whoever captures Peter – and proceeds to pop his claws out. The three men, even more stupid than they look, aim their guns at Wolverine and prepare to shoot. Moving at lighting speed, Wolverine disarms them and incapacitates two of them. The third miscreant takes off running – ditching his ski mask along the way – praying that Wolverine is not coming after him. As he comes around a corner, his thoughts are interrupted by the appearance of the Punisher, who pulls a gun and aims it at his head. Terrified, the man begs the Punisher not to kill him. The Punisher lowers his gun, grabs hold of the thug, and slams him headfirst into a brick wall. Still holding on to the thug, the Punisher tells him that he is releasing him only because he wants him to spread the word that Midtown High is off-limits to scum like him and that there is a squad of heroes guarding the place 24/7 to make sure it stays that way. The man promptly agrees and is then thrown into a pile of garbage cans by the Punisher. When the man gets back on his two feet, the Punisher is nowhere to be found. Feeling extremely lucky to be alive, the man takes off in a hurry. On a nearby rooftop, the Punisher watches on, a small cylindrical device in his hand. Pressing on one of its buttons, the Punisher transforms into Wolverine, and then transforms into Spider-Man!

ACT 3: Flashback to a few days earlier, after the Mysterio(s) fiasco, Peter – as Spider-Man – is accosted by Miss Arrow, the school nurse, who calls him selfish and irresponsible for leaving the school and his students. Peter is taken aback by her comment and explains that he is now too well recognized and, as such, his presence at the school is and will always be a constant threat to the students and teaching staff. Nurse Arrow argues that his absence will actually be more detrimental, as no one will be there to protect them, should another villain decide to strike at the school. Peter replies that he understands that; however, the students' parents want him out. Nurse Arrow explains that, at that very moment outside, parents are all breathing a sign a relief that their kids are safe thanks to him. She, on the other hand, is holding her breath until the next attack, which could very well be the following day, or the day after, etc. She knows that villains will continuously try to use the students to lure him back to the school, because of his emotional attachment to Midtown High. Peter understands her position but has no idea what he is supposed to do.

ACT 4: Back in the present, inside prison walls, the Vulture sits in a dark cell, only slightly illuminated by a single spotlight in the ceiling. Via an intercom system, someone tells the Vulture that he is incarcerated there because of the whole Superhuman Registration Act and the fact that he is a known thief and murderer. Despite this, the Vulture is offered freedom in exchange for taking care of Spider-Man, who recently decided to join the anti-registration movement led by Captain America. When presented with his costume and associated gauntlet, the Vulture gladly accept.

ACT 5: Later that day, at Midtown High, a man by the name of Ben Reilly meets with Roger, the school principal, as he is interested in coming to work at the school.

ACT 6: In a flashback sequence, taking place a few days earlier, Spider-Man meets with Beast, of the X-Men, in an abandoned church. After discussing their individual stance with the Superhuman Registration Act, Beast hands Spidey a small remote control in the shape of a cylinder. When Spidey asks what it is for, Beast explains that it is an image projector, which will change his appearance and will allow him to blend in the crowd (thus revealing that Spidey used it to pass as both Wolverine and the Punisher, as well as changing his appearance to "become" Ben Reilly). Thanking Beast, Spidey spins a web and takes off. As he swings away from the church, he notices a giant busted-up cocoon in the gable of the church rooftop. For an instant, he wonders what could have been in it (Please read Marvel Knights Spider-Man #22 for additional information).

ACT 7: Back in the present, Peter-as-Ben is informed by the school principal that the position of science teacher, for which he was applying, has been filled. Disappointed, Peter-as-Ben prepares to leave but Roger tells him that they have a vacant position as assistant-teacher in the physical education department. Despite knowing that he is going to have to work for Flash Thompson, Peter accepts the offer.

ACT 8: On his way home, Peter is stunned when he walks by a Daily Bugle newspaper vending machine and catches a glimpse of the latest edition's front page, which has an article about Deb Whitman's book about him. Ripping the door off the vending machine, Peter grabs a copy of the paper and begins to read the article, which has excerpts from her book that are not flattering towards Peter to say the least. Furious that she would say such thing about him, Peter decides to confront her about it at her book signing to be held later that day.

ACT 9: Coincidently, elsewhere, the Vulture plans to crash the book signing, as he is confident that Peter Parker will show up because Peter always seeks approval from those who hate him. Because he is weak and Vultures pray on the weak.

To be continued.