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KNIFE The weapon I prefer to get rid of right away. This weapon is close to useless unless you're in desperate need. I recommend not using it at all unless you have to. Like at the beginning of both character's adventure. It may be good against crows and other small enemies but I still would recommend the handgun instead. So in short terms just throw the damn thing in your item box.
PISTOL The most preferred weapon for pretty much the whole first 1/4th of the game. You should use this on all of the easy enemies like zombies, Cerberus, crows, and snakes. But once you get through the police station and up to the sewer by then you should be using the shotgun as your all around weapon because the handgun isn't very effective against the stronger enemies. Keep it in your inventory for pretty much the whole game because you'll come across a couple of weak enemies every once in awhile. You can upgrade this weapon once you receive the handgun parts.
CUSTOM HANDGUN A better upgraded version of the handgun. Once you receive the handgun parts combine them with your pistol and it'll be quicker allowing you to fire 5 shots at once. You can set it to auto, the 5 bullet at once shot, or normal where it just shoots one bullet at a time. Use this rather then the standard handgun once received.
SHOTGUN Probably the best all around weapon throughout the whole game. You find a pretty good amount of ammo for it and it's quick in killing enemies. Take out zombie's heads with it because you'll save ammo instead of chest shots, which take 2 or 3. Don't use it against dogs because it'll take the same amount of shotgun shells to kill it, as it will handgun bullets. But I recommend always having it equipped up until the lab. By the way, only Leon can receive this weapon.
CUSTOM SHOTGUN A very powerful weapon. Once you receive the shotgun parts you can combine them with your old shotgun to get this upgrade and what a damn good upgrade it is. This thing can kill just about any enemy in a shot or two besides big guys but yet it is also very powerful against them. Aim it up at zombies heads to blast their whole head and shoulders off from the massive blast. It has a very powerful kick to it also. Only available to Leon.
CROSSBOW A majorly unreliable weapon. It shoots 3 arrows at once, holds 15 arrows, and ammo is extremely rare. Plus the 3 arrows shoot in 3 different directions so it's pretty unpredictable wether it's gonna hit an enemy or not. The enemies like zombies even take about 6-9 arrows before dying which is alot. So I recommend only using it when your near big crowds of enemies or when you have no other weapon to use. Only Claire can receive this weapon.
GRENADE LAUNCHER Another weapon that should only be used on tougher enemies. Although not as powerful as the magnum you can get up to 3 different types of ammo for it- Grenade rounds, Flame rounds, and Acid rounds. All of the ammo does about the same amount of damage. Flame rounds are more rare to find then Acid rounds and Grenade rounds. Don't use the bazooka for long range shooting because the rounds don't fire that far. Only Claire can receive this weapon.
MAGNUM Another weapon that you should always have in your inventory during your return to the mansion. It's one of the most powerful besides for the custom magnum, custom shotgun, and rocket launcher. You should always use this against Mr. X because it'll take him out in a couple shots. Since you don't get very much ammo for it only use it on the tougher enemies. Definitely use it against the big guys if you don't have the sparkshot or custom shotgun. You can also upgrade this weapon once you receive the magnum parts in the weapon box locker in the lab. Only available in Leon's game.
CUSTOM MAGNUM The ultimate most powerful weapon. You need to receive the magnum parts from the weapon box locker in the lab before you can use this. Once you receive it you can kill just about any enemy in one shot. Besides for the big guys that is. But even on the big guys this can do some major damage. I definitely recommend using this on the big mutation at the end of the game. Only Leon can receive this weapon.
FLAME THROWER You can only find and use this weapon towards the very end of the game and isn't very powerful. Once you find it in the lab you can use it on the plant ivy enemies but that's pretty much it. It's ammo runs out quickly since it only has 100%. It also takes up 2 slots on your inventory screen. Don't use it on the big guys because it's too slow. SPARKSHOT Claire's most powerful weapon. It's found in the factory on a dead
zombie's body. Don't forget to pick it up because it's easy to pass. It takes up 2 inventory slots and uses alot of it's ammo for every shot. Only use on the big enemies because you can't get more ammo for it and the ammo you do have runs out very fast. So only use it on big guys because it'll just be a waste on the smaller ones. Only available to Claire.
SUBMACHINE GUN A quick but not very powerful weapon. It's pretty much what it says. A machine gun and everyone should know what a machine gun is. It's one of the few weapons that both Claire and Leon can equip. Found in the weapon room locker in the police station basement. It's only there in the B game if you decide to leave it there in the A game. As well as the sidepack. You can earn this gun with unlimited ammo after beating the B game. Read how in the secrets section.
GATLING GUN A Terminator 2 resembling weapon which is very quick and can take out groups of enemies in seconds. This sucker takes a second to start but once it does every thing in it's path will be gone. Although it's not available in the game you can receive it with unlimited ammo once beating the B game. Read more about it in the secrets section. Available to both Claire and Leon.
ROCKET LAUNCHER The all-time most powerful weapon in the game but then again most rare. You can only get it at the very end of the game in the final battle against the Mr. X Tyrant. With only 2 rockets that is. This can kill all the enemies, besides the bosses, in one shot. If you can manage to beat the B game with an A then you'll be awarded with the rocket launcher and unlimited ammo in your next game. If you save it to a memory card that is. Read more about it in the secrets section.