Active ingredients, metabolism,
Of the approximately 400 different chemicals found in Cannabis, the main active ingredient is tetrahydrocannabinol (delta-9-tetrahydrocannabinol, THC).

THC can degrade to CBL and CBN (other cannabinoids), which can make one feel sleepy and disoriented.
Different cannabis products have different ratios of these and other cannabinoids.

Depending on the ratio, the quality of the "high" will vary. THC has an effect on the modulation of the immune system which may have an effect on malignant cells, but there is insufficient scientific study to determine whether this might promote or limit cancer.

Cannabinoid receptors are also present in the human reproductive system, but there is insufficient scientific study to conclusively determine the effects of cannabis on reproduction. Mild allergies to cannabis may be possible in some members of the population.
and method of activity:
A study has shown that holding cannabis smoke in one's lungs for longer periods of time does not conclusively increase THC's effects

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