Pinky and the Brain, WB
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Listen, I haven't seen as much of this as I should have, and I'm sorry about that. Anyway, so we have these lab mice at Acme Labs. Pinky, who is stupid and crazy and hilarious, NARF! And the Brain, who is brilliant and wants to take over the world and is always annoyed at Pinky, his friend and assistant. He always has some brilliant and crazy plan to take over the world. It's all really clever and funny and you need to watch it. I should say more... but then again, it really is the same thing every time, trying to take over the world. Also I guess it was a spin-off from Animaniacs.