| Rank | Song | Artist | Points | |
| 50 | |
I Call It Love | Lionel Richie | 555 |
| 49 | |
Change Me | Ruben Studdard | 556 |
| 48 | |
Far Away | Nickelback | 556 |
| 47 | |
Dear Mr. President | Pink f/ Indigo Girls | 556 |
| 46 | |
Unappreciated | Cherish | 561 |
| 45 | |
Snap Yo Fingers | Lil' Jon f/ E-40 & Sean Paul of the YoungBloodz | 572 |
| 44 | |
I'm N Luv (Wit A Stripper) | T-Pain f/ Mike Jones | 587 |
| 43 | |
My Love | Justin Timberlake f/ T.I. | 598 |
| 42 | |
Grillz | Nelly f/ Paul Wall, Ali, & Gipp | 598 |
| 41 | |
What You Know | T.I. | 606 |
| 40 | |
Sexy Love | Ne-Yo | 607 |
| 39 | |
Check On It | Beyonce f/ Slim Thug | 608 |
| 38 | |
In My Mind | Heather Headley | 614 |
| 37 | |
Wanna Love U Girl | Robin Thicke f/ Pharrell | 616 |
| 36 | |
Say Goodbye | Chris Brown | 626 |
| 35 | |
Ridin' | Chamillionaire f/ Krayzie Bone | 627 |
| 34 | |
Can't Let Go | Anthony Hamilton | 628 |
| 33 | |
Money Maker | Ludacris f/ Pharrell | 629 |
| 32 | |
Buttons | Pussycat Dolls f/ Snoop Dogg | 630 |
| 31 | |
Enough Cryin' | Mary J. Blige | 635 |
| 30 | |
DJ Play A Love Song | Jamie Foxx f/ Twista | 650 |
| 29 | |
SexyBack | Justin Timberlake | 677 |
| 28 | |
Everytime Tha Beat Drop | Monica f/ Dem Franchize Boyz | 688 |
| 27 | |
Unpredictable | Jamie Foxx f/ Ludacris | 697 |
| 26 | |
Crazy | Gnarls Barkley | 701 |
| 25 | |
Get Up | Ciara f/ Chamillionaire | 702 |
| 24 | |
Too Little, Too Late | JoJo | 704 |
| 23 | |
Dani California | Red Hot Chili Peppers | 710 |
| 22 | |
Say I | Christina Milian | 715 |
| 21 | |
Bossy | Kelis f/ Too Short | 717 |
| 20 | |
Crowded | Jeannie Ortega f/ Papoose | 718 |
| 19 | |
Ain't No Other Man | Christna Aguilera | 719 |
| 18 | |
Not Ready To Make Nice | Dixie Chicks | 741 |
| 17 | |
London Bridge (Oh Snap!) | Fergie | 749 |
| 16 | |
Gallery | Mario Vazquez | 750 |
| 15 | |
So Sick | Ne-Yo | 754 |
| 14 | |
So What? | Field Mob f/ Ciara | 760 |
| 13 | |
Pullin' Me Back | Chingy f/ Tyrese | 769 |
| 12 | |
S.O.S. (Rescue Me) | Rihanna | 777 |
| 11 | |
Call On Me | Janet Jackson f/ Nelly | 779 |
| 10 | |
Yo (Excuse Me Miss) | Chris Brown | 781 |
| 9 | |
Hips Don't Lie | Shakira f/ Wyclef Jean | 783 |
| 8 | |
The Real Thing | Bo Bice | 795 |
| 7 | |
Give It Up To Me | Sean Paul f/ Keyshia Cole | 802 |
| 6 | |
Promiscuous | Nelly Furtado f/ Timbaland | 817 |
| 5 | |
Savin' Me | Nickelback | 858 |
| 4 | |
Do It To It | Cherish f/ Sean Paul of the YoungBloodz | 869 |
| 3 | |
Temperature | Sean Paul | 894 |
| 2 | |
Be Without You | Mary J. Blige | 919 |
| 1 | |
One | Mary J. Blige f/ U2 | 1047 |
Music Central's Top 150 Songs Of 2006 (150 - 101)
Music Central's Top 150 Songs Of 2006 (100 - 51)
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