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Benfotiamine Research
Bergfeld R, Matsumara X. Du, Brownlee M. Benfotiamin prevents the consequences of hyperglycemia-induced mitochondrial overproduction of reactive oxygen species, and experimental diabetic retinopathy. “diabetic rats were treated with benfotiamin (80 mg/kg weight) for 36 weeks…Benfotiamin decreases AGE formation by 60%...These data suggest that treatment with benfotiamin may be an effective approach to prevent the development of diabetic complications” Lin J, Alt A, Liersch J, Bretzel R, Brownlee M, Hammes H. Benfo inhibits intracellular formation of advanced glycation end products in vivo “Here, we studied the effect of benfo, a lipid-soluble thiamine derivative with known AGE-inhibiting properties in vitro on the intracellular formation of (CML) and methylgloxal-derived AGE in red blood cells. Blood was collected from 6 type 1 diabetic patients before and after treatment with 600 mg/day benfo for 28 days…Thiamine derivatives, in particular the lipid-soluble prodrug benfo, are effective inhibitors of intracellular formation of AGE and CML” note that "benfo" was substituted for "benfotiamine"
