Medical Advances and Immortality

For this page, this is various readings I’ve done and tried to put it together over time as sort of a research paper. It’s been slow and for many years, I actually was just doing all of this for myself, so I haven’t recorded many of my references, although I have presented a few here and there once I felt I should likely go ahead and include some. This ‘paper’ was originally supposed to try to tie in to both my dragon research and religious studies, so it started off with a bit of background information on them and then tries to build up to some more modern method ways people try to extend their lives. I know that some is not precise, some is just portions of copy and paste from sites I went to because they literally did not need rewording in my opinion. I have a desire for a long life, and so that is why I eventually began this particular ‘paper’ to begin with, and also since I did feel I could put all things together as both a history and methods of practices. I’ve seen books that show me parts here and there, however never just one complete ‘story’ necessarily. I know ancient folks used to try to do this, and they were successful in a number of ways for their time. So, if you find this useful, I’m glad. Someday, I hope to be able to further my typing and be able to get things more precise. I think it would be good. I would like to thank teachers I’ve had though, and also a person I met only a few times named something similar to Gaelin. They, along with my mother, and a feeling for correct information, inspired me to try to research anything at all many years ago.

--Image to the left is me, Olli Copperwolf, and was taken by me in what’s known as an event mascot/fursuit to some.--

 

Who is God, where did he come from, and what relation does the name Yahweh have to things? (need to state that Yahweh was the mountain god, but also was compared to the god/alien El Elion/El/Enki(du) (also Jesus), and is therefore just another name for the original name of Enki.

What is Immortality?

Immortality (or eternal life) is the concept of living in a physical or spiritual form for an infinite or inconceivably vast length of time.

As immortality is the negation of mortality—not dying or not being subject to death—it has been a subject of fascination to humanity since at least the beginning of history. The Epic of Gilgamesh, one of the first literary works, dating back at least to the 22nd century BC, is primarily a quest of a hero seeking to become immortal. What form an unending human life would take (as well as whether it is subject to incapacitation), or whether the soul exists and possesses immortality, has been a major point of focus of religion, as well as the subject of speculation, fantasy, and debate.

It is not known whether human physical immortality is an achievable condition. Biological forms have inherent limitations which may or may not be able to be overcome through medical interventions or engineering. As of 2009, natural selection has developed biological immortality in at least one species, the jellyfish Turritopsi nutricula, one consequence of which is a worldwide population explosion of the organism.

What are some things said to cause aging and why? (14 theories of aging here)

1. Programmed cell death and the telomere "end replication problem" are found even in the earliest and simplest of organisms. Telomere is a 'cap' on the ends of DNA that help cells to split and recreate. These eventually wear down and at that point a cell actually dies because it can no longer replicate itself anymore. This can be caused by oxidation on the body, which can increase as a person ages due to leakage of electrons from mitochondria in a cell. Leakage increases as energy production increases without the proper protection. This can be lessened, as even pidgeons have this leakage issue, however their protection is greater. Cutting down on the leakage causing oxidation, ie the release of ROS (reactive oxidative substances) in experiments, has caused extension in lifespans.

2. Cell death and telomere shortening may have originally became noticeable after the other set of beings (Gods) took a typical creature from earth and injected some of the being dna into them in order to increase the evolutionary change of the creatures which became a more modern man and have them take on more of an image of the ‘creators’. Something in this either caused longer life or for aging to be rapidly progressed from what it was. Either way, there was a change in lifespans of people during these times that these beings were supposedly here.

3. Mutation accumulation is another theory, formulated by Peter Medawar in 1952, to explain how evolution would select for aging. Essentially, ageing is never selected against, as organisms have offspring before the mortal mutations surface in an individual.

4. Yet another theory is the disposable soma theory was proposed in 1977 by Thomas Kirkwood, which states that an individual body must allocate energy for metabolism, reproduction, and maintenance, and must compromise when there is food scarcity. Compromise in allocating energy to the repair function is what causes the body gradually to deteriorate with age, according to Kirkwood.

Has anyone or anything ever actually lived forever?

1.     A jellyfish, after becoming a sexually mature adult, can transform itself back into a child (the polyp stage) using the cell conversion process of transdifferentiation. Turritopsis nutricula repeats this cycle, meaning that it may have an indefinite lifespan.- why? how does it do it? what is its secret?

The fertilized eggs develop in the stomach and in the screen formed by the cave in the jellyfish planula. The eggs are then planted on the seabed in polyp colonies. The jellyfish hatches after two days. The jellyfish becomes sexually mature after a few weeks (the exact duration depends on the ocean temperature; at 20 °C (68 °F) it is 25 to 30 days and at 22 °C (72 °F) it is 18 to 22 days).

Jellyfish usually die after propagating; however, the Turritopsis nutricula has developed the ability to return to a polyp state. This is done through a cell change in the external screen (exumbrella). The cells revert to a different state. The medusa is transformed into a stolon and the polyps into a hydroid colony. The umbrella turns inside out; middle section and tentacles are reabsorbed before the polyp spawns. Stolons form two days before the polyps differentiate. The ability to reverse the life cycle is probably unique in the animal kingdom, and allows the jellyfish to bypass death, rendering the Turritopsis nutricula biologically immortal. Lab tests showed that 100% of specimens reverted to the polyp stage

2.     Next on the list of immortals is supposedly the Vedic and the post-Vedic rishis (such as Markandeya) attained physical immortality, Sri Aurobindo states, which includes the ability to change one's shape at will, and create multiple bodies simultaneously in different locations.

3.     Jesus

4.     Enki(du) (in one version of the tablets), and the ‘gods’ others from the Sumerian stories from the Epic of Gilgamesh. (Jesus is Enki, still alive after a very incredibly long time) (Jesus has been compared to the sun and to some degrees, can be understood in an astrological sort of way.)

The Epic of Gilgamesh, an epic poem from Mesopotamia, is amongst the earliest surviving works of literature. The literary history of Gilgamesh begins with five independent Sumerian poems about 'Bilgamesh' (Sumerian for Gilgamesh), king of Uruk. Four of these were used as source material for a combined epic in Akkadian. This first, "Old Babylonian" version of the epic dates to the 18th century BC and is titled Shūtur eli sharrī ("Surpassing All Other Kings"). Only a few fragments of it survive. The later, Standard Babylonian version dates from the 13th to the tenth centuries BC and bears the title Sha naqba īmuru ("He who Saw the Deep"). Fragments of approximately two thirds of this longer, twelve-tablet version have been recovered. Some of the best copies were discovered in the library ruins of the 7th-century BC Assyrian king Ashurbanipal.

The story centers on a friendship between Gilgamesh and Enkidu. Enkidu is a wild man created by the gods as Gilgamesh's equal to distract him from oppressing the people of Uruk. Together, they journey to the Cedar Mountain to defeat Humbaba, its monstrous guardian. Later they kill the Bull of Heaven, which the goddess Ishtar sends to punish Gilgamesh for spurning her advances. As a punishment for these actions, the gods sentence Enkidu to death.

The later half of the epic focuses on Gilgamesh's distress at Enkidu's death, and his quest for immortality. In order to learn the secret of eternal life, Gilgamesh undertakes a long and perilous journey to find the immortal flood hero, Utnapishtim. He learns that "The life that you are seeking you will never find. When the gods created man they allotted to him death, but life they retained in their own keeping." His fame however lived on after his death, because of his great building projects, and his account of what Utnapishtim told him happened during the flood.

5.     Utnapishtim, the immortal flood hero whom Enki(du) was looking for from the Epic of Gilgamesh stories so as to gain immortality. Various themes, plot elements, and characters in the Epic have counterparts in the book of Genesis, notably in the stories of the Garden of Eden and Noah's Flood.

The parallels between the stories of Enkidu/Shamhat and Adam/Eve have been long recognized by scholars.[15] In both, a man is created from the soil by a god, and lives in a natural setting amongst the animals. He is introduced to a woman who tempts him. In both stories the man accepts food from the woman, covers his nakedness, and must leave his former realm, unable to return. The presence of a snake that steals a plant of immortality from the hero later in the epic is another point of contact.

Andrew R. George submits that the flood story in Genesis 6–8 matches the Gilgamesh flood myth so closely, "few doubt" that it derives from a Mesopotamian account.[16] What is particularly noticeable is the way the Genesis flood story follows the Gilgamesh flood tale "point by point and in the same order", even when the story permits other alternatives.[17]

In a 2001 Torah commentary released on behalf of the Conservative Movement of Judaism, rabbinic scholar Robert Wexler stated: "The most likely assumption we can make is that both Genesis and Gilgamesh drew their material from a common tradition about the flood that existed in Mesopotamia. These stories then diverged in the retelling."

Anunaki?

All of these are said to have had an immortal body in one way or another.

What’s are some other bodies aside from those that are placed as human (includes human-like bodies people were created from) that have been placed as Immortal? (have to change this up some perhaps due to newfound information and should be taken from the what are immortal bodies from dragon research)

If jesus is god .. enki is god, that means they are either of the original group of advanced beings that came to earth and/or made of pure blood.. Enki tells a melchazedick, and then melch prophesise of a child that will come in the future, Jesus, who would be the god as a man (implying that the dna had been worked around some more). That atleast tells how god could have told of himself and still been different people, because the term god represented the upper class of advanced beings, just as the term Satan(which actually means wise man in older days) applied to the lower class of advanced beings. Enki would have already been familiar with the workings of dna, so could have worked things out where mary could be impregnated without having to have been with a man. This would have not made a creature as what’s known as a nephilim as direct contact would (possibilities of all sorts of anomalies cropping up (example similarity : STD).

What have some of these been compared to and what do they have to do with immortality? (what are some different types of immortal bodies section combined with comparisons. Need to make sure to separate what is considered somewhat fiction/religious necessarily from the scientific as alternates, but need to shift in to some of the dragon research so it can be placed below for a book. Try to keep things separated for your own purposes after you are done creating a single document for the book)

(Rest of Dragon Research goes here?)

What are some things being researched to help lengthen life?

1.     Scientists believe that boosting the amount or proportion of a naturally forming enzyme, telomerase, in the body could prevent cells from dying and so may ultimately lead to extended, healthier, lifespans. Telomerase is a protein that helps maintain the protective caps at the ends of chromosomes.[23] A team of researchers at the Spanish National Cancer Centre (Madrid) tested the hypothesis on mice. It was found that those mice which were genetically engineered to produce 10 times the normal levels of telomerase lived 50% longer than normal mice.[24]

2.     In normal circumstances, without the presence of telomerase, if a cell divides recursively, at some point all the progeny will reach their Hayflick limit. With the presence of telomerase, each dividing cell can replace the lost bit of DNA, and any single cell can then divide unbounded. While this unbounded growth property has excited many researchers, caution is warranted in exploiting this property, as exactly this same unbounded growth is a crucial step in enabling cancerous growth.

3.     Telomerase was boosted by 30 percent in prostate cancer patients who followed a plant-based, whole-grain diet with very little fat or sugar for three months. The men also took fish oil supplements, did daily 30-minute bouts of exercise, and practiced yoga or meditation for an hour a day. "Telomerase turns up those genes associated with disease prevention and turns down the genes associated with heart disease, diabetes, and cancer," explains Ornish. Excersice upregulates a thing called PCG-1alpha, which has been shown to help extend lifespan.

4.     Transdifferentiated stem cells are another way of slowing down mortality and increasing life span. Differentiation means ability of a cell of a certain type of dna to change itself depending on what job it is supposed to do, in size shape, etc, although the code is the same. The only cells able to differentiate fully for everything are stem cells. Transdifferentiation means that a cell such as a stem cell has already changed/differentiated and has a set path it is taking, but it is taken from that path, mixed with other cells that are not the same type, and caused to differentiate again off of its original intentions and begin mimicking the newly introduced cells. Basically, one cell changing into another type of cell. An example of this would be in salamanders and chickens when the lens of the eye is removed, cells of the iris turn into lens cells.

5.      Another ‘theory’ is regular exposure to low dose ionized radiation is elt to be another way to atleast cut down on various types of cancer, rather than causing it. This is called radiation hormesis. In a publication from 2009, using a revised hormetic relative risk model for cancer induction that accounts for both epigenetic activation (epiactivation) and episilencing of genes, it was demonstrated at one point that, on average, >80% of alpha-radiation-induced rat lung cancers were prevented by chronic, low-rate gamma ray ANP. Interestingly, lifetime exposure to residential radon at the Environmental Protection Agency’s action level of 4 pCi L−1 appears to be associated with on average a > 60% reduction in lung cancer cases, rather than an increase. The title of the publication was Radiation-Stimulated Epigenetic Reprogramming of Adaptive-Response Genes in the Lung: An Evolutionary Gift for Mounting Adaptive Protection Against Lung Cancer.

6.      The next item, NF-kB, is one of the body’s regulatory means for handling situations of stress, cancer, damage or disease. Activating hundreds of the body’s natural antioxidant and stress defense genes, the Nrf2/Keap1 pathway provides a central mechanism for most if not all forms of generally favorable biological responses to low exposures of toxins and other stressors, also known as hormesis. In eukaryotic cells NF-kB is an important regulator of genes that control cell proliferation and cell survival. NF-kB regulates anti-apoptotic genes that protect healthy cells from cell death and activates the expression of genes that keep cells proliferating. On the other hand, activated NF-kB binding to genes has long been known to play a central role in promoting runaway inflammation and inflammation’s negative consequences. — These consequences include promotion of angiogenesis, proliferation, metastasis and invasiveness in cancer tumors, autoimmune diseases, neurodegenerative diseases and contributing to the activation of human immunodeficiency virus (HIV) leading to AIDS.  – There appears to be increasing evidence that inhibition of expression of NF-kB could be a key approach for fighting cancers, controlling inflammatory diseases, AIDS, neurodegenerative conditions like Parkinson’s Disease and a number of other significant age-related maladies. — Recent studies position NF-kB even more centrally with respect to longevity. It is likely that NF-kB expression is central to a programmed set of changes which we call aging. One study(ref1) confirms that that in multiple mammalian tissues (including skin fibroblasts, kidney, cortex, kidney medulla, abdominal muscle, skeletal muscle, and brain), aging involves continuing changes in expression of hundreds of genes. And, further, NF-kB signaling appears to be a major regulator of gene expression related to the aging progress. In fact, by inhibiting NF-kB cell signaling the researchers were able to cause the epidermal tissue of old mice to revert to the state of very young mouse tissue, both in observable characteristics and in genetic expression profile. The authors show that NF-kB cell signaling is a meta-factor for determining aging of nine other key cell types as well, and they argue that the results should apply equally to humans and other mammals.” NF-kB can be regulated more though by creating an anti-inflammatory environment, which is hostile to cancer cells since there is a relationship between Nrf2 and cancer. This can be helped by eating the right foods, and taking the right supplements.

7.     Moving on, you should eat some foods that are natural HDAC (?) inhibitors. These are foods which are already on my list of foods, but here they are here as well. Some natural HDAC inhibitors are broccoli and broccoli sprouts (both have sulforaphane), garlic (1 garlic bulb per day), chives, shallots, regular and purple onions (higher in vitamin c though), brussels sprouts, cabbage (also saur kraut which is made from cabbage), cauliflower, horseradish, kale, mustard, watercress, tomatoes, apples, citrus (ruby red grapefruit), turmeric (curcumin)(chicken curry), soybean, coffee, cinnamon, tea, broccoli, cashew nuts, grapes

8.     A certain level of mitochondrial antioxidatives can be good to have, but having too much can also have a negative effect on mitochondria. While increasing mitochondrial antioxidation can be useful for life extension, a recent idea to cut down on a leak of electrons from mitochondria has been found might be better. Some key mitochondrial antioxidants are alpha-lipoic acid, acetyl-l-carnitine, melatonin and buckyballs in particular. Another item, known as buckyballs mixed with olive oil, is a mitochondrial antioxidant, and could be useful to keep the mitochondria giving energy, but due to leakage of electrons, the extra energy might still cause aging and harm to the mitochondria itself, however this item also has a ‘possibility’ of increasing lifespan substantially according to experiments done with rats. Certain mitochondrial mutation polymorphisms appear to be associated with exceptional longevity in human subpopulations, and mitochondrial antioxidant interventions extend the lives of mice and other lower species. Analyzing single mutations in 10 different degenerative conditions across five species, Wright and collaborators found that age of onset and severity of disease correlates closely with the rate of ROS leakage. “If we could slow ROS leakage, there’s a prospect we could delay the onset of a wide spectrum of degenerative diseases,” he says. Since mtDNA spin off so much ROS and are damage-prone and have limited self-repair capability, it seems logical to surmise that what is going on with aging is increasing amounts of mutationally damaged mtDNA and that this is correlated with greatly increased susceptibility to age-related neurological and other diseases.  This is actually a quite established view of aging, articulated the years ago in the publication Oxidative Stress, Mitochondrial DNA Mutation, and Impairment of Antioxidant Enzymes in Aging1.  “Mitochondria do not only produce less ATP, but they also increase the production of reactive oxygen species (ROS) as by-products of aerobic metabolism in the aging tissues of the human and animals. So from how I understand it, as we get older, the mitochondria release more electrons that causes oxidation wear and tear, and the body can't keep up with it, and we should try to cut down on the ‘key’ mitochondrial antioxidents, but not completely, especially since necessary.

What are different ideas ‘claiming’ as possibilities to achieve Immortality or increase lifespan?

Metaphysical universals and abstract phenomena have an eternal existence, and if they can be interacted with by human beings, then a person might obtain a degree of immortality by interacting with them.

Quantum immortality is not widely regarded by the scientific community as being a verifiable or even necessarily correct offshoot of the many worlds interpretation. In the many worlds interpretation of quantum mechanics, the wavefunction never collapses, and thus all possible outcomes of a quantum event exist simultaneously, with each event apparently spawning an entirely new universe in which a single possible outcome exists. In this theory, a person could hypothetically live forever as there might exist a string of possible quantum outcomes in which that individual never dies.

Life extension technologies promise a path to complete rejuvenation. Cryonics holds out the hope that the dead can be revived in the future, following sufficient medical advancements. Modern cryonics procedures use a process called vitrification which creates a glass-like state rather than freezing as the body is brought to low temperatures. This process reduces the risk of ice crystals damaging the cell-structure, which would be especially detrimental to cell structures in the brain, as their minute adjustment evokes the individual's mind.

Mind uploading is the concept of transference of consciousness from a human brain to an alternative medium providing the same functionality. Assuming the process to be possible and repeatable, this would provide immortality to the consciousness, as predicted by futurists such as Ray Kurzweil. With mind uploading, the individuals memory may be loaded to a computer or to a newly born baby's mind. The baby will then grow with the previous person's individuality, and may not develop its own personality. Extropian futurists like Moravec and Kurzweil have proposed that, thanks to exponentially growing computing power, it will someday be possible to upload human consciousness onto a computer system, and live indefinitely in a virtual environment. This could be accomplished via advanced cybernetics, where computer hardware would initially be installed in the brain to help sort memory or accelerate thought processes. Components would be added gradually until the person's entire brain functions were handled by artificial devices, avoiding sharp transitions that would lead to issues of identity. After this point, the human body could be treated as an optional accessory and the mind could be transferred to any sufficiently powerful computer.

Robert Freitas, a nanorobotics theorist, suggests tiny medical nanorobots could be created to go through human bloodstreams, find dangerous things like cancer cells and bacteria, and destroy them. Freitas anticipates that gene-therapies and nanotechnology will eventually make the human body effectively self-sustainable and capable of living indefinitely, short of severe trauma. This supports the theory that we will be able to continually create biological or synthetic replacement parts to replace damaged or dying ones. This is the most likely concept to try to work towards achieving and understanding, and would basically be turning a person into a cyborg of sorts, and could possibly lead to even more implants that would possibly lead to full robotic body replacement, however nanorobots should be sufficient enough until further studies done on mind transfers from human body to robot body.

6.     Yet another view of immortality is traced to the Vedic tradition by the interpretation of Maharishi Mahesh Yogi:

 

That man indeed whom these (contacts)

do not disturb, who is even-minded in

pleasure and pain, steadfast, he is fit

for immortality, O best of men. 

 

To Maharishi Mahesh Yogi, the verse means, "Once a man has become established in the understanding of the permanent reality of life, his mind rises above the influence of pleasure and pain. Such an unshakable man passes beyond the influence of death and in the permanent phase of life: he attains eternal life… A man established in the understanding of the unlimited abundance of absolute existence is naturally free from existence of the relative order. This is what gives him the status of immortal life." This, to me, is saying that the responsible steadfast person will be able to make wise descisions and control various influences on his life well enough to be able to use them to extend life, and can make it through any circumstance with ease.

7.     Buddhism teaches that there is a cycle of birth, death, and rebirth and that the process is according to the qualities of a person's actions. This constant process of becoming ceases at the fruition of Bodhi (enlightenment) at which a being is no longer subject to causation (karma) but enters into a state that the Buddha called amata (deathlessness)

8.     Bible passages in Christianity are interpreted as teaching that the resurrected body will, like the present body, be both physical (but a renewed and non-decaying physical body) and spiritual. Honestly, with what I have read in religion, and the things I have learned, come to understand, and now believe, I feel that this was a look at the future, or at a present that was leftover from another time which fell greatly. We, as people are working towards this… to try to make heaven on earth.

How are the so-called magical orders tied in with these things? (talk about how they are old ways of showing worship and such to the old gods which are not around currently except for any which were killed, which in that case, some of them have met the same fate as many people… life after death and still being able to interact)(they had early interaction with the aliens and were the brighter people of the time)

What is a good plan to follow to help try to live longer?

Vitamins (reasons for some, and a daily regimen below that):

Any and all vitamins below are what I plan to take. They may possibly more effective if allowed to integrate with a liquid. They have 0 to extreme low calories usually. The same plan may not work for you. I am attempting to follow someone else’s regimen. Basically, as he learns, I learn. Some of the ones listed on the chart are obtainable enough through eating the right foods. Some of these, and certain of the foods, are also supposed to help increase the Hayflick limit, but so is exercise.

Take these vitamins * = not necessary when right foods are eaten:

1.       -TMG – trimethylglycene - 500mg tabs – used for homocystiene levels to avoid various older age diseases for longer

2.       *-B50 Vitamin Complex in correct amounts - used for homocystiene levels to avoid various older age diseases for longer. atleast 400mcg of folic acid daily if not more for memory and for controlling homocystiene levels to avoid various older age diseases for longer, and do not go over 2000mg of niacin in a day. Try not to take too much niacin, as it is more for aging.

3.       *-Vitamin C – Good as an antioxidant. It can cause kidney stones, diahrea, and other unpleasant things in too high of amounts. Usually 1000mg is fine daily. It is easy to get this from right foods though.

4.       *-Calcium - Nothing over 2000mg per day.

5.       *-Magnesium - detrimental to many functions inside the body. Magnesium can help with practically all things. It lowers histamine levels in the body (what antihistamines do), which can help clear up allergy type symptoms, help with schitzophrenia, help with tmj issues, etc. If no money to purchase the vitamin, then go with okra. Take milk with this at a high enough level so there's no shortage. Calcium and magnesium are absorbed better when together, but not so well when one is higher than the other. (400 mg). Get with a multivitamin if available in right amount.

6.       *-Fish oil supplements - naturally increase telomerase production some and cuts down on the rate at which telomeres degrade, as well as find high omega fats that help control and lower weight. Make sure to get purified for mercury types and with atleast a 400mg combined between DHA and EHA. Eat 1-2 cans of bumblebee light tuna in oil for this daily if unable to get or afford supplements.

7.       *-Quercitin - inhibits the expression of HSP70 in cancer cells. Found in broccoli, raspberries, black tea, green tea, red wine, red onions, tomatos. Red onion and the teas contain the most. Eat red onion skin.

8.       *-L-Carnosine – 3 – 4 grams daily (8oz (1cup) daily of either chicken or beef). Helps slow down the methylation of dna strands and greatly increases the amount of times cells can divide, thereby inturn helping to stay younger for longer. Increases GABA in the body and can increase pain and stress tolerance. Carnosine is very abundant in protein-rich foods. Some common examples of such foods include milks, eggs and cheese. However, the best food sources of carnosine include beef, poultry and pork products. Beef has about 1,500 mg carnosine per pound. Poultry has about 2,000 mg carnosine per pound. Pork has about 2,000 mg per pound.

9.       *-L-theanine – found in green tea. If you want natural occurring l-theanine, switch over to a high grade green tea, which may contain as much as 50 milligrams per cup. High grade green tea is normally made from young tea buds harvested early spring. They need not be expensive. As far as theanine goes, my personal favorites are the Dragon Well and Biluochun tea.

10.   -astragalaside IV - helps various stem cells in the body to begin producing again instead of sitting around and doing nothing; telomerase activator by RevGenetics. antiinflammatory, antifibrotic and antioxidant. take before resveratrol because it increases ability to get through blood brain barrier

11.   -cycloastragenol - replacement for astragalaside IV. Helps various stem cells as well as regular cells in the body to begin producing again instead of sitting around and doing nothing. telomerase activator by RevGenetics. 10x nire effective than astragaloside IV. take before resveratrol because it increases ability to get through blood brain barrier

12.    -Reserveratrol - orally and hold in mouth for a few minutes and let it soak through and then swallow the rest. Take max amount allowed daily once less expensive. Reduces inflammation. It can be found in red wines and /japanese knotroot for amounts that do any good. activates sirt1. Reservatrol also increases natural testosterone and helps protect the lungs from cigarette smoke to a degree. Oral administration of resveratrol (5mg/kg b.w) to streptozotocin-nicotinamide-induced experimental diabetic rats for 30 days significantly normalizes the levels of blood glucose, plasma insulin, glycosylated hemoglobin, AST, ALP, ALT, and modulates the altered activities of carbohydrate metabolizing enzymes in the liver and kidney tissus of diabetic rats. (take into account a rat’s average weight vs. human weight, and also take into consideration any notices for overdose). It was seen to increase ampk which is released during muscle stimulation, but in this case there is no stimulation in occurance. Ampk basically turns on various energy producing pathways and is also seen as life extending qualities. In a study of 123 Finnish adults, those born with certain increased variations of the SIRT1 gene had faster metabolisms, helping them to burn energy more efficiently—indicating that the same pathway shown in the lab mice works in humans. Mice fed resveratrol for fifteen weeks had better treadmill endurance than control mice. The study supported Sinclair's hypothesis that the effects of resveratrol are indeed due to the activation of the Sirtuin 1 gene. The sirtuin 1 gene basically increases the regulation by proteins against stressors and helps increase cellular longevity. These sirtuin proteins are usually produced by yeast, some of which can be found in red wines, however tests with red wines show that there is not enough available in drinking of red wine to be effective. Sirt1 genes lock onto the proteins in order to work. In mice, oral resveratrol also produced large reductions in brain plaque in the hypothalamus (-90%), striatum (-89%), and medial cortex (-48%) sections of the brain. In humans it is theorized that oral doses of resveratrol may reduce beta amyloid plaque associated with aging changes in the brain. Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (remove) copper. Nicholas Wade's interview-article with Dr. Auwerx states that the dose was 400 mg/kg of body weight (much higher than the 22 mg/kg of the Sinclair study). For an 80 kg (176 lb) person, the 400 mg/kg of body weight amount used in Auwerx's mouse study would come to 32,000 mg/day. Compensating for the fact that humans have slower metabolic rates than mice would change the equivalent human dose to roughly 4571 mg/day.

13.   -DHEA - Supplementing hormones for men not living with women. 6 months longer in mice and must be quite a bit longer in humans. Inhibits mTOR pathway which is increased with use of niacin (b3). May only mimic calorie restriction for obese people, allowing them to continue eating alot but keep an average lifespan. Can cause hairloss on rare occasions, but not with everyone and mainly women. Otherwise, this is quite safe even in higher amounts. If using synthesized DHEA, then do not take higher doses. Naturally only found in wild yam from Mexico extracts currently. Use 7 Keto DHEA if hairloss begins to be experienced with regular DHEA. If an individual's DHEA levels were healthy enough, there would be no need for estrogen, or testosterone, melatonin or other hormone replacements, as the DHEA hormone would naturally supply your body with whatever hormone your body happened to be lacking.

14.   –Turmeric  / Curcumin – limit to 1 pill per day with lunch. It reduces inflammation. It can be found within turmeric spice or on its own as a spice on shelves in stores. It is a chemo preventive agent with potent anticarcinogenic activity in a wide variety of tumor cells. Curcumin inhibits cancer cell proliferation in part by suppressing cyclin D1 and inducing expression of the cyclin-dependent kinase inhibitor p21. Ground from the root of a plant (Curcuma longa L.) of the ginger family, found wild in the Himalayas and grown across South Asia. Don’t use often or ever. Causes faster telomerase shortening.

15.   -Co Q-10  or COQH - protect mitochondria and also provides energy. This is found highest in sardines, however not enough is provided to make it of any real benefit. Supplementing with it with q-sorb or as coqh vs. coq10 is much better.

16.   -Alpha-lipoic acid - protect mitochondria. Stops unwanted cell death. Can come with carnatine. Can be found in broccoli, spinach, collard greens, and even tomatoes, however it’s effectiveness is significantly less and of no real benefit in such small amounts. Eat natural foods with this in it since they are useful for other things than just ALA, but not taking supplementation for this will cut down on ALA muchly, and too much ALA can harm the mitochondria.

17.   -acytl-l-carnitine - protect mitochondria and reduce telomere shortening. Stops unwanted cell death. Can come with alpha-lipoic.

18.   -Melatonin – natural sleep aid.

19.   -Ginko biloba - activates telomerase in non-cancer cells, and helps to prevent various types of cancer. 60mg most days, and no more than 120mg ever, although up to 300mg on very rare occasions is ok. Increased level of energy and better circulation. This plant also increases circulation to the penis to achieve rock-solid erection for a better sexual performance. More blood coming into the penis results to bigger erection. 78% of men suffering from non-medically related impotence had experienced the powerful results of Gingko Biloba without any side effects.

20.   -Valerian - for now. volproaic acid later when it comes out and trials or done or possibly given by medic at health clinic after being seen. Good for bipolar and depression, as well as an anti-inflammatory and help with twitching. Best taken at night.

21.   *-Vitamin D3 - histone unwrapping inhibitor - helps to prevent an item that causes inflammation, and that enters the nucleus of a cell from activating. A histone is a string down the middle of a set of dna strands. They wrap around the histone, and can unwrap as well. These must be kept wrapped around the histone in order to inhibit inflammation. Get with milk instead of a pill.

22.   -Bromelain – anti-inflammatory, and helps continue to help hair grow well. It is found in pineapples, however not in high enough amounts to do any good.

23.   -Glucosamine Chondroitin sulphate - cartilage structure

24.   -Ashwagandah - cancer prevention and heart, as well as male performance sexual enhancement.

25.   -Boswellia seratta - cancer prevention and heart

26.   -Trichostatin A - histone unwrapping inhibitor - helps to prevent an item that causes inflammation, and that enters the nucleus of a cell from activating. A histone is s string down the middle of a set of dna strands. They wrap around the histone, and can unwrap as well. These must be kept wrapped around the histone in order to inhibit inflammation.

27.   -Nature’s Bounty - covers C, D3, E, zinc, and other important vitamins

28. - Cordyceps - type of chinese mushroom that protects lungs and kidneys by making it easier to breathe and function. Can supposedly cure a few different cancers. Also increases amount of testosterone In the body. Only take if experiencing urinary problems.

If male, take these supplements that are good for enlarging a penis and/or atleast helping to keep function at a more nominal level :

1.       -Hawthorn berry – lowers blood pressure, but has sexual benefits. Other things already lower blood pressure, and therefore this might not be good.

2.       -Catuaba Bark Extract - all around nervous system revitalizer. It restores your nervous system function bringing about increased brain function, reduced nervousness, better sleep and improved sexual function. This is the herb that has helped the 60, 70, 80 even 90 year olds in Brazil have a healthy sex life naturally. There are no known side effects with catuaba except the occasional upset stomach and diarrhea when it is first introduced to the diet. The main concern is that you are actually purchasing real catuaba bark, as there are several exporters who export the bark as catuaba, but it is in fact from the wrong tree. There are 2 forms of catuaba tree that supplies the actual bark that is medicinally known for its benefits and the scientific names for these two is Erythroxylum catuaba and Trichilia catigua. The standard daily dose is 1000mg to 2000mg. There has not been any standardization of the extract’s concentration.

3.       -Damiana - found primarily in Central and South America. It is recorded being used as early back as the ancient Mayan civilization to prepare for lovemaking. Today it is used to relieve headaches, control bed wetting, better control of the muscles in the urinary tract, as an aphrodisiac and to enhance orgasms.

4.       -Safflower oil

5.       -Horny Goat Weed – aka Epimedium Leaf Extract. It had been found to contain icariin which can increase erectile function. It also increases blood circulation to the penis. More blood supply to the penis means a larger and stronger erection. Furthermore, it can stimulate the release of the male hormone, testosterone, which is responsible in increasing a male's libido and sexual endurance. It can come in strengths between 5% and 60%, most higher than that only being used in labs.

6.       -Cuscuta Seed Extract - increases the amount of live sperm cells of a man. It is also a known solution to premature ejaculation, a common problem among some men which greatly affects their sexual relations. A bigger, harder and more sustained erection is the male enhancement benefit of this natural ingredient. It is used in conjunction with other herbs to treat a wide range of conditions, ranging from impotence, premature ejaculation and frequent urination, to blurred vision and dry eyes. Because of its ability to reduce the loss of fluids from the body, cuscuta was once considered a "longevity herb."

7.       -Ginseng is well known as a sexual stimulant. The Chinese have long held this herb in high esteem, it is supposedly the herbal fountain of youth. It is both a stimulant and relaxant on the central nervous system and improves muscle stamina! A herb full of vitality and often used by men who have a loss of sex drive. There are cautions to take when using Ginseng. Do not take consistently and not for more than three weeks at time. Do not take during pregnancy and avoid with high blood pressure.

8.       -Saw Palmetto Berry - Native American Indians considered the ripe fruits of the saw palmetto a tonic and an aphrodisiac. The berries do, in fact, have a toning effect on the male reproductive system and have been employed for impotence and prostate problems. It can be used to treat prostate enlargement and cystitis.

9.       -Fenugreek – a type of spice and seed. It should be available in capsule form if not available in the spices isle. – doesn’t seem to have any relevance at all to sexual functions or growing.

10.   *-L-Arginine - L-arginine is converted to nitric oxide which aids in the relaxation of blood vessels. The effect is better blood circulation in the body and especially in the extremities (eg. genitalia). For this reason L-arginine helps in stimulating and maintaining erection (at least in males). Men with erectile dysfunction may benefit from intake of L-arginine rich foods or l-arginine supplement. L-arginine is a major component of ejaculate (seminal fluid and sperm) and therefore it is important for maintaining healthy ejaculate volume. Other L-arginine benefits include maintainance of nitrogen balance, removal of excess ammonia, liver detoxification, reduction of alcohol toxicity effects, wound healing, and treatment of sterility in men. 4oz to 9oz per day.

Obtained and slightly edited by me after reading more recent info than when this originally made from http://www.vincegiuliano.com/Antiagingfirewalls.htm :

Vitamin C - 1gm

500mg morning, 500mg evening

Vitamin D-3 – 2000 IU

Twice daily

Probiotic - 10 major strains + fructooligosaccharides, a prebiotic

Twice daily

Curcumin extract – 1160 mg

Twice daily

B-50 complex - (50 mg for most)

Twice daily

Vitamin B-12 - 500mcg - Included in B50

Once daily

Benfotiamine – 80mg

Twice daily

Vitamin B-6 – 100mg - Included in B50

Twice daily

Pantothenic acid – 500mg

Twice daily

Mixed carotenes

Once daily

Folic acid – 900mcg included in B-50. Do not exceed

Once daily

N-Acetyl Cysteine (NAC) 600mg

Once daily

Chelated copper 2.5mg

Once daily

Potassium gluconate 100mg

Once daily

Calcium (as carbonate, aspartate, citrate) 1 Gm

Twice daily

Magnesium (as oxide, aspartate, gluconate) – 500mg

Twice daily

Zink (as oxide, aspartate, gluconate) – 30mg

Twice daily

Selenium – 200 mcg

Once daily

R-alpha-lipoic acid 100 mg

Twice daily

Acetyl-l-carnitine 500mg

Twice daily

L-carnosine - 500mg

Before breakfast, before bed

Co-enzyme Q-10 (Ubiquinol) – 300mg (100mg Ubiq.)

Twice daily

Bitter melon extract (mordica charantia) 500 mg

Twice daily

Bromelain – 250mg

Twice daily

Lycopene – 15mg

Twice daily

Quercetin – 500mg

Twice daily

Ginkgo Biloba extract (stand. to contain 24% flavone glycosides and 6% terpene lactones) - 60 mg

Once daily

Saw palmetto (stand. to 85-95% fatty acids) – 200mg

Twice daily

Ashwagandah extract (stand. to 1.5% withanolides) -  470mg

Twice daily

Boswellia Seratta (stand. to 70% organic acids and 20% boswellic acid)extract - 300mg

Twice daily

Horny Goat Weed Extract (Epimedium sagittatum)
(standardized to 20% icariin)(leaf) 1000mg

Once daily

Olive leaf extract (stand.to 20% oleuropein) - 750mg

Twice daily

Green tea extract (stand. to 60% polyphenols) – 1.5gm

Morning

OPC  grape seed extract (stand. 120 seeds/mg)

Twice daily

Omega-3 oils: DHA - 400mg; EPA - 800mg

Three morning; one evening

Micronized resveratrol - 250mg

Twice daily

Avena Sativa 19:1 extract – 1,150mg

Twice daily

Allicin or garlic extract- 1gm

Twice daily

Milk Thistle Extract (Silybum marianus) (seeds)
[Standardized to 80% flavonoids as silymarin (120 mg)]

Twice daily

Bacopa (Bacopa monnieri) (whole herb)
[standardized for 45% bacosides 135 mg)] 300mg

Twice daily

Stinging Nettle Each capsule supplies 250 mg of stand. nettle extract (1% silicic acid) and 270 mg of powdered root.

Twice daily

L-theanine 100mg

Twice daily

Phosphatidylcholine – 385mg

Once daily

Glucosamine sulfate 750mg -- Do not exceed

Twice daily

Piracetam - 800 mg

Morning

Meclofenoxate  (centrophenoxine) - 500mg

Morning

DHEA 50mg (25mg for now for me)

Morning

Pregnenalone - 60mg

Morning

Melatonin - 3mg

Before bedtime

 

Eat these Foods - Follow mainly plant-based whole grain diet with very little fat or sugar - naturally increase telomerase production some. :

1.       -Tuna – lower calories and also containing omega 3 for weight and heart health. Occasionally have instead of beef. It’s better to take fish oil with high enough DHA and EHA amounts though, which combined should be 400 to 500mg at minimum daily. 1000 should be plenty otherwise. 2 cans of Bumblebee tuna with omega 3’s daily will work just fine.

2.       -Fat free turkey sausage or slices – beef is better as long as eaten with or after antioxidant foods.

3.       -Eggs – certain brands are high in omega 3, vitamin e, and other good vitamins. 1 or 2 daily. Cholesterol contained in eggs is not bad. Eggland’s best is currently best.

4.       -Water - metabolism

5.       –White tea or Green Tea – metabolism and various cancer prevention. Heavy in antioxidant power. Find teas that use young leaves, as there is more natural theanine in it, and typically atleast about 30-50mg per cup. Most likely available as leaf packages rather than prepared. The thenine also helps to cancel out too much caffination. Has Quercitin. White tea is better.

6.       -Diet Dr. Pepper – no calories or sugar, and good for soda cravings.

7.       -Blueberries - cognition, neural inflammation,  alzheimer’s disease, cancer, and cardiovascular health - powerful anti-inflammatory. ½ to 1 cup per day (2oz to 4oz (8oz only when have the money) per day).

8.       -Red wine – 8-16 oz per day (1 – 2 cups). Has quercitin.

9.       -Extra lean ground beef or larger 80/20 logs if low on money - has some vitamin benefit, but just do not overdo. 8 oz is plenty by itself daily, and mixed with vegetables or on side. 8oz of Turkey Sausage equals about the same as this amount. Beef does have a higher amount of carnosine over the turkey though.

10.   -Non-fat refried beans - higher calories but more filling in smaller amounts, so actually low calories, fiber, protien

11.   -Brocolli - low calories in 1 cup, massive vitamin C and K, has sugars but low amounts . Make very regular in the diet. Delays lung cancers and helps with breathing as well as coagulation to cut down on blood loss. Has quercitin. Try to only do 4oz (1/2 cup per day so as to control the vitamin k). Contains sulforathane

12.   -Baby dill pickles - don't eat more than 3 whole in a day (stops vitamin k from being as effective. vitamin k helps with blood clotting). 0 calories with right ones. Not too many, as these have vinegar in them, and vinegar is not a good product to have a lot of.

13.   -Okra - high vitamin k, 14% magnesium, good vitamin C, fiber, low calories in 1 cup raw. Only do ½ cup if eating this in order to avoid too much vitamin k(4oz)

14.   -Cucumbers – caffeic acid which is anti-inflammatory.

15.   -Tomatoes and tomato sauces and pastes – Contain lycopene. Low calories though, so sugars should be as well. It is better to heat them up just a little, as that makes more lycopene for some reason. Has quercitin.

16.   Lettuce – just good as a little extra tastes and filler.

17.   -Red onion – has quercitin in highest, and most bioavailable amounts. The dry skin must be eaten with these.

18.   -Grapefruit, orange, etc. and their peals – anti-inflammatories with caffeic acid.

19.   -Bell/Green Peppers – Caffeic acid with anti-inflammatory properties.

20.   -Fat free cheddar cheese - no fat, it's cheese, it has 40% calcium per slice. 30 calories per slice.

21.   -Fat free milk – 2 - 3 cups of milk in one day. Water and/or tea needs to be drank along with milk. Take magnesium with this. (1000mg calcium daily). Try to use 1 cup (90 calories), and have cheese or supplementation otherwise.

22.   -Special K original  – decent calories and vitamins for cereal. 4 oz daily.

23.   –Walnuts - improves memory deficits and learning skills. Also contains L-arganine which is good for sexual function. 5.5 oz per day. Have this or peanuts for 1 day, but not both.

24.   -Sugar free Chocolate syrup – good for extra tastes on things occasionally. Has no fat or sugar, and low calories.

25.   -Peanuts – Contain l-arganine which is good for sexual function. 4oz per day. Have this or wal-nuts for 1 day, but not both. Plain.

26.   -Fat free yogurt – better than milk in vitamins, and more filling. Not much higher in calories, and also still fat free. 4 to 8oz daily (1/2 to 1  cup or heaping spoons to 10 heaping spoons).

27.   -Various herbs and spices - good for various things. Try to stick with cinnamon (with breakfast only), cayenne pepper (blood thinner. Put 1 – 2 tsp on breakfast item), black pepper (lunch), and oregano (blood thinner. Use this only with dinner), curry spices, garlic powder. These are all good as anti-oxidants and anti-inflammatories, and In some cases anti-viral.

28.   -Horseradish - strong antibiotic, expectorant, bronchodilatator, antibacterial, coronary vasodilatator, it increases the blood pressure, it heats up the body, stimulates the body's immune system, anti-inflammatory, antiparasitic, antianemic, antiscorbutic, diuretic. It can stimulate the appetite. It has a cardiotonic effect and is recommended to the people that suffer from high blood pressure. Also it is known that horseradish has aphrodisiacal properties.

29.   -Raw Garlic - garlic may have health benefits such as lowering cholesterol and blood pressure, protecting the heart and arteries, boosting immunity, increasing anti-allergy effects, and helping in cancer prevention and therapy.

30.   -Extra virgin olive oil - reduces pro-inflammatory, pro-oxidant and pro-thrombotic markers. Regular olive oil will not do. Try to make sure to get authentic EVOO vs. the bad stuff.

31.   -Dark chocolate - phytochemical and caffeic acid. Have 2-3 squares per day depending on the brand, sugar, and fat content.

32.   -Salt - needed for healthy synapses, but most things come with this, so not really very necessary unless after iodine content.

Do these other things:

1.     30 minutes of exercise a day - naturally increase telomerase production some. Do not over excersise, as this is actually harmful to the body. More than 30 minutes is ok, but better to do short and fast exercising in increments. ( about 15 minutes multiple times a day in order to really benefit)

2.     Follow breathing techniques on kundalini while doing meditation for 1 hour or longer. It is basically the same idea as a practice so-called rebirthers take, but is done to simply relieve stress and let the energy that some people believe in to come up through the spine and give enlightenment, power, and more energy to do things. It naturally increases telomerase production some.

3.     Become established in life and have understanding to it. Do not be shaken at anything, but do not give in when it is not necessary.  By doing this, a person could actually gain a title of sāttvika. A person or creature can be called sāttvika if the creature has predominantly sāttvika tendencies. The word Sattva itself means ‘pure’. A sāttvika (pure person) individual always works for the welfare of the world. He is always hardworking, alert and lives life moderately. He leads a chaste life. He eats moderately. He speaks the truth and is bold. He never uses vulgar or insulting language. He does not feel jealous nor is he affected by greed and selfishness. He does not cheat or mislead anyone. He does not even allow any evil tendencies to enter his mind. He has good memory and concentration. He also has keen interest in improving his spiritual knowledge, and spends time worshiping god or meditating. In the extreme state he may even perform penance or uninterrupted meditation. A satvic individual can be recognized if his mind, speech and actions synchronize. Manasa, vacha, karmana are the three Sanskrit words used to describe such a state. In the Indian language, these three words are together used to describe a state of consistency expected of an individual. These three aspects of an individual must synchronize. An individual is expected to speak exactly what he thinks, and do only those things that he believes in. He must not do something which his mind asks him not to do. Neither must he speak something that he does not believe in. It also means that the individual must promise exactly what he can deliver. He must not promise something that he cannot or does not intend to do. It also means that he must think before doing anything or saying something. That essentially means his mind has complete control over his body. Such a thing is not easy, and the expectation is that the individual would strive to attain such a noble ideal

4.     Watch for updates on technological life increasing items.

5.     Have orgasms regularly, even if not to completion. This will extend life, as well as help blood flow, and possibly enlargement, and if dairing enough, eat it, as it does contain nutrition, including creatine.

6.     Keep a positive attitude, and stay calm, as not doing so will shorten a life span. One type of name given to a certain type of person who has achieved high levels on a number of grounds with these things is known as Sattva – pure.

A person or creature can be called sāttvika if the creature has predominantly sāttvika tendencies.

A sāttvika (pure person) individual always works for the welfare of the world. He is always hardworking, alert and lives life moderately. He leads a chaste life. He eats moderately. He speaks the truth and is bold. He never uses vulgar or insulting language. He does not feel jealous nor is he affected by greed and selfishness. He does not cheat or mislead anyone. He does not even allow any evil tendencies to enter his mind. He has good memory and concentration. He also has keen interest in improving his spiritual knowledge, and spends time worshiping god or meditating. In the extreme state he may even perform penance or uninterrupted meditation. A satvic individual can be recognized if his mind, speech and actions synchronize. Manasa, vacha, karmana are the three Sanskrit words used to describe such a state.

In the Indian language, these three words are together used to describe a state of consistency expected of an individual. These three aspects of an individual must synchronize. An individual is expected to speak exactly what he thinks, and do only those things that he believes in.

He must not do something which his mind asks him not to do. Neither must he speak something that he does not believe in. It also means that the individual must promise exactly what he can deliver. He must not promise something that he cannot or does not intend to do. It also means that he must think before doing anything or saying something. That essentially means his mind has complete control over his body. Such a thing is not easy, and the expectation is that the individual would strive to attain such a noble ideal.

Another similar example would the 3 wise monkeys (hear no evil, see no evil, do no evil)

What is reservatrol and How does it help?

-resveratrol ends up on longer life span page on wikipedia after it ends up on a page about my head pressure problem..-what is this and what does it do and where can get it from?

Oral administration of resveratrol (5mg/kg b.w) to streptozotocin-nicotinamide-induced experimental diabetic rats for 30 days significantly normalizes the levels of blood glucose, plasma insulin, glycosylated hemoglobin, AST, ALP, ALT,[20] and modulates the altered activities of carbohydrate metabolizing enzymes in the liver and kidney tissus of diabetic rats. (take into account a rat’s average weight vs. human weight, and also take into consideration any notices for overdose). It was seen to increase ampk which is released during muscle stimulation, but in this case there is no stimulation in occurance. Ampk basically turns on various energy producing pathways and is also seen as life extending qualities.

In a study of 123 Finnish adults, those born with certain increased variations of the SIRT1 gene had faster metabolisms, helping them to burn energy more efficiently—indicating that the same pathway shown in the lab mice works in humans. Mice fed resveratrol for fifteen weeks had better treadmill endurance than control mice. The study supported Sinclair's hypothesis that the effects of resveratrol are indeed due to the activation of the Sirtuin 1 gene. The sirtuin 1 gene basically increases the regulation by proteins against stressors and helps increase cellular longevity. These sirtuin proteins are usually produced by yeast, some of which can be found in red wines, however tests with red wines show that there is not enough available in drinking of red wine to be effective. Sirt1 genes lock onto the proteins in order to work.

In mice, oral resveratrol also produced large reductions in brain plaque in the hypothalamus (-90%), striatum (-89%), and medial cortex (-48%) sections of the brain. In humans it is theorized that oral doses of resveratrol may reduce beta amyloid plaque associated with aging changes in the brain. Researchers theorize that one mechanism for plaque eradication is the ability of resveratrol to chelate (remove) copper.

Reservatrol increases natural testosterone and helps protect the lungs from cigarette smoke to a degree.

Nicholas Wade's interview-article with Dr. Auwerx states that the dose was 400 mg/kg of body weight (much higher than the 22 mg/kg of the Sinclair study). For an 80 kg (176 lb) person, the 400 mg/kg of body weight amount used in Auwerx's mouse study would come to 32,000 mg/day. Compensating for the fact that humans have slower metabolic rates than mice would change the equivalent human dose to roughly 4571 mg/day.

Resveratrol has been found to be natural in a number of different foods, and to some degrees actually bioavailable now. (shift this up to the vitamins section if resveratrol becomes quite common, and update foods with this in it).

What is the Hayflick Limit?

The so-called "Hayflick limit" is a finding by Dr. Hayflick, many years ago, that fibroblast cells, in culture, will only have a finite number of doublings, after which they stop dividing and become senescent. However, a fibroblast is a somatic terminally differentiated cell which produces collagen. In contrast, all tissues which make extensive use of fibroblasts, including skin, bone, etc., are also well well supplied with fibrocytes.

Fibrocytes are undifferentiated stem cell versions of fibroblasts. They are not yet functioning to produce anything. When you were young, they continually produced replacement skin cells for no other reason other than the fact that they could. But, with increasing age, fibrocytes, and other stem cells become more and more likely to just sit there, waiting, in your skin, and elsewhere. Sometimes they may wait for many years, until some kind of serious damage is perceived by the body. This might include peeling by acids, lasers or otherwise. In the face of massive injury, the fully differentiated fibroblasts generate large numbers of signalling molecules, chemicals such as cytokines, which tell the fibrocytes

"It is time to come out of slumber. You need to make new fibroblasts."

Generally, the fibrocyte will then divide, producing one fibroblast destined copy, and one fibrocyte to replace itself. Depending on how bad the damage is, and how persistently the existing fibroblasts call for help, this same process may repeat itself, over and over again, until many eventual fibroblasts may be produced by one fibrocyte. But, always, one replacement fibrocyte will remain.

Like all stem cells, fibrocytes produce a certain amount of telomerase, and we are able to measure this in skin, after injury. Telomerase is an enzyme that acts to elongate the chromosomal "caps" called telomeres/ In mitosis, other enzymes, which stimulate division and duplication of the chromosomes, bind to each chromosome by holding it at the telomere. As a result, the particular nucleotides are blocked, and they cannot be copied. This results in a progressive shortening of the telomere caps.

Thankfully, there is a lot of telomere, at least to begin with. And, furthermore, the telomeres don't code for any needed proteins. So, losing a bit of nucleotide sequence is not devastating to the cell. However, the telomeres are essential for chromosomal stability. A measurable length of telomeric nucleotides are sacrificed with each population doubling. The telomere eventually becomes so short there is barely anything left for the mitosis enzymes to latch onto, and the cell stops dividing. That is called senescence, and the maximum number of times that a fibroblast can divide is called the "Hayflick Limit.

Fibrocytes, however, unlike fibroblasts, produce a sub-optimal amount of telomerase. This enzyme functions to add back sections to the telomere after mitosis, restoring the chromosomes to the pristine state it once enjoyed, prior to the time that the cell divided itself. I say sub-optimal because adult stem cells do not produce enough telomerase to quite equal the rate of telomere shortening. Unlike embryonic stem cells, therefore, adult stem cells do, eventually, become senescent. The time it takes for that to happen, however, is so far beyond the so-called "Hayflick Limit", that an adult stem cell is essentially "immortal," when we are talking about people who currently live to a maximum life span of about 120 years. We have enough skin stem cells, producing enough telomerase, to last a lifetime of well over 1,000 years.

How can this be? Well, as stated, your existing stock of stem cell fibrocytes are sufficient to regenerate your skin for 1,000 years. Indeed, if you believe the quasi-historical accounts in the Bible, people, like Methuselah, once did live that long. We could, potentially, even lengthen stem cell productivity far beyond that. All you would need to do is, somehow, figure out how to upregulate the production of telomerase in adult stem cells. If you did that, successfully, you would have the potential of eternal life, and eternally renewing skin. You could do as much peeling as you wanted, and never ruin your skin.

We actually have some idea on how to upregulate the transcription of telomerase, in individual cells. It has been done in the laboratory, most recently by the Geron Corporation. The most important hurdle to achieving eternal life is not in upregulating telomerase. What we don't understand is how, why, and what signaling mechanisms are involved in causing the normally quesient stem cells to activate to the point where they replace worn out somatic cells, as they do when we are young.

It has been shown that blood, from a young animal, transfused into an older animal, stimulates stem cell activity, and replacement of somatic cells, especially in areas of the body that have been injured. Scientists have shown that the healing response, of old animals, can be restored to the level of youth, simply by transfusing young blood into them. Conversely, by transfusing old blood into younger animals, healing can be retarded.

All of this takes us back to the Bible, once again. In Genesis, God says that "the life is in the blood." Well, now, we know that this is true. The problem, as always, is that we don't know why or how.

It is abundantly obvious that there is an unknown substance, in the blood of younger animals which is in much shorter supply, in older blood. This unknown chemical(s) stimulates mobilization of stem cells. Mobilization of stem cells, in turn, acts to maintain the organism in a youthful state. Stem cells are stimulated, to regularly replace worn out somatic cells (such as fibroblasts, in the skin). Such microscopic activity can be seen, macroscopically, by the increased turnover of skin cells and healthier looking skin of the young, compared to the aged. In a very primitive way, by utilizing techniques that burn off the outer layer of skin with acid, lasers, etc., we are trying to stimulate some of the chemicals of youth.

Beyond all this, we just learned, about 2 years ago, in addition to normal stem cells, our skin, and that of all other animals, also has abundant reserves of an unusual type of stem cell, dubbed "spore-like" stem cells. We call them spore-like because, like the spores from fungus or bacteria, these mammalian spores are very basic packages of DNA, and lack most of the baggage of full developed stem cells and somatic cells.

From their structure, spore-like stem cells probably should function like a sort of emergency "backup" DVD. If the computer fails, you put this backup in, to restore the system. Similarly, if the stem cells fail, the spore like stem cells can take their place. These cells have all the same basic DNA codes of normal cells, but the DNA is tightly wound, the tiny amount of cytoplasm surrounding the DNA has a very limited number of mitochrondria, and they are coated with tough membranes, designed to withstand great stress. If called into action (and we don't know how to do that yet) spore-like stem cells can quickly absorb nutrients from the surrounding serum, multiply mitochondria to full numbers, activate their nuclei, and convert themselves from "compressed archives" into full fledged stem cells. These can then further differentiate, like any other stem cell, into terminal somatic cells, repairing damaged tissues.

Spore-like stem cells are highly resistent to heat. acids, radiation, etc. If we knew more about stimulating them, we could, potentially, use one single spore-like stem cell to reconstitute the entire organism.

For unknown reasons, at the present time, not only are spore-like stem cells "disabled", but normal stem cells stop replacing worn out parts, for unknown reasons, simply because we reach a certain age. And, humans are not the only animals that suffer from aging. All mammals, and almost all (but not quite all) other species, do, also.

Theoretically, aging is an aberration that the living organisms should not be subject to. We can see, in experiment after experiment, that the human body can and should be fully capable of maintaining itself for a 1,000 years, or more, even without direct genetic tampering. Yet, this does not happen. It seems as if some very knowlegeable person (God?) has deliberately turned off the backup systems, forcing aging and death. All the talk about anti-oxidants only addresses the issue of prolonging the life of somatic cells. Stem cells, with limited exceptions, are not susceptible to being worn out by oxidation.

The term somatic (from the Greek σωματικός) refers to cells of the body, rather than gametes (eggs or sperm). In humans, somatic cells contain two copies of each chromosome (diploid), whereas gametes only contain one copy of each chromosome (haploid). Although all somatic cells of an individual are genetically identical in principle, they evolve a variety of tissue-specific characteristics during the process of differentiation, through epigenetic and regulatory alterations.

Somatic is also defined as relating to the wall of the body cavity, particularly as distinguished from the head, limbs or viscera. It is also of or relating to the portion of the vertebrate nervous system which regulates voluntary movements.

Perhaps, "God" has ceased to exist, or is preoccupied with other things. Or, maybe, a genetic error randomly occured billions of years ago, in an early organism, which, over time, transformed itself in most of the current forms of life we see on earth. Whatever the reason, our job, as scientists, is to learn how to switch these backup systems back "on" again. If and when we do, it will no longer be necessary to worry about anti-oxidants and similar treatments to keep worn-out somatic cells running as long as possible.

 

Medical Advancement:

1.     With major neurological diseases such as ALS, Huntington’s disease (HD), Multiple Scleroris (MS), Parkinson’s Disease and Alzheimer’s Disease – and even autism, the root cause is thought to be mitochondrial dysfunction resulting from mtDNA damage and leading to excess levels of reactive oxygen and nitrogen species.

Extra Notes:

-telomerase - increased amount can protect cells and stop the 'caps' from being broken down slowly off of dna, however how it works is very similar to how cancer forms. it is found in embryonic stem cells, and only in the cells that need to divide in adults, unlike with embryos they are creating everything and therefore found in all parts. - where get from? how to increase it?

According to Blackburn's opinion at most of her lectures, it is a big mistake to think that telomerase is involved with only extending telomeres. Stopping glycolysis in cancer stem cells and preventing the upregulation of 70 bad genes is probably what is killing cancer stem cells if they are using alternative methods.

Basically, the telomerase items available stop telomerase from actually being used by cancer cells, extend the telomeres, and provide a type of immortality to various cells by keeping the telomeres on DNA strands from shortening, however the telomeres are not the clock for a person’s life..

 The Aghori are a Hindu sect believed to have split off from the Kapalika order (which dates from 1000 AD) in the fourteenth century AD. Most other Hindus condemn them as non-Hindu because of their cannibalistic rituals. Aghoris or Aughads command extreme reverence from rural populations as they are supposed to possess powers to heal and relieve pain gained due to their intense practices.

The Aghoris distinguish themselves from other Hindu sects and priests by their alcoholic and cannibalistic rituals. The corpses, which may be either pulled from a river [including Ganges] or obtained from cremation grounds, are consumed both raw and cooked on open flame, as the Aghoris believe that what others consider a "dead man" is, in fact, nothing but a natural matter devoid of the life force it once contained. Therefore while for ordinary folks cannibalism may be seen as primitive, barbaric as well as unclean, for aghori's it's being both resourceful and subverting the common stereotypes placed on such taboos into a spiritual ascertainment that indeed nothing is profane nor separate from God, who is hailed to be all and in all. In fact, the Aghoris see it as a scientific approach in trying to discover how matter converts from one form to another

Rhodiola (aka golden seal) can supposedly help quite a bit with Alzeimers, as well as Parkinson’s

An adaptogen is a metabolic regulator which increases the ability of an organism to adapt to environmental factors, and to avoid damage from such factors.

Following individuals who expose themselves to radon gas in the US (4 old mines near the towns of Boulder and Basin in Montana) and Europe (Gasteiner Heilstollen, Austria; Schlema & Sybyllenbad, Germany; Radium Palace, Czech Republic) for health effects. Some of these individuals have been doing this on a regular basis for 10-20 years. A study of NR2F/Keap pathway gene expression in a leukocyte microarray transcriptome post exposure would be of great interest. Here is an article on this: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2477705/

 

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