| Issue Date | Song | Artist |
| June 6 1960 | "Cathy's Clown" | The Everly Brothers |
| June 13 | "Cathy's Clown" | The Everly Brothers |
| June 20 | "Cathy's Clown" | The Everly Brothers |
| June 27 | "Everybody's Somebody's Fool" | Connie Francis |
| July 4 | "Everybody's Somebody's Fool" | Connie Francis |
| July 11 | "Alley Oop" | Hollywood Argyles |
| July 18 | "I'm Sorry" | Brenda Lee |
| July 25 | "I'm Sorry" | Brenda Lee |
| August 1 | "I'm Sorry" | Brenda Lee |
| August 8 | "Itsy Bitsy Teenie Weenie Yellow Polka Dot Bikini" | Brian Hyland |
| August 15 | "It's Now or Never" | Elvis Presley |
| August 22 | "It's Now or Never" | Elvis Presley |
| August 29 | "It's Now or Never" | Elvis Presley |
| September 5 | "It's Now or Never" | Elvis Presley |
| September 12 | "It's Now or Never" | Elvis Presley |
| September 19 | "The Twist" | Chubby Checker |
| September 26 | "My Heart Has a Mind of Its Own" | Connie Francis |
| October 3 | "My Heart Has a Mind of Its Own" | Connie Francis |
| October 10 | "Mr. Custer" | Larry Verne |
| October 17 | "Save the Last Dance for Me" | The Drifters |
| October 24 | "I Want to Be Wanted" | Brenda Lee |
| October 31 | "Save the Last Dance for Me" | The Drifters |
| November 7 | "Save the Last Dance for Me" | The Drifters |
| November 14 | "Georgia on My Mind" | Ray Charles |
| November 21 | "Stay" | Maurice Williams and the Zodiacs |
| November 28 | "Are You Lonesome Tonight?" | Elvis Presley |
| December 5 | "Are You Lonesome Tonight?" | Elvis Presley |
| December 12 | "Are You Lonesome Tonight?" | Elvis Presley |
| December 19 | "Are You Lonesome Tonight?" | Elvis Presley |
| December 26 | "Are You Lonesome Tonight?" | Elvis Presley |
| January 2 1961 | "Are You Lonesome Tonight" | Elvis Presley |
| January 9 | "Wonderland by Night" | Bert Kaempfert |
| January 16 | "Wonderland by Night" | Bert Kaempfert |
| January 23 | "Wonderland by Night" | Bert Kaempfert |
| January 30 | "Will You Love Me Tomorrow" | The Shirelles |
| February 6 | "Will You Love Me Tomorrow" | The Shirelles |
| February 13 | "Calcutta" | Lawrence Welk |
| February 20 | "Calcutta" | Lawrence Welk |
| February 27 | "Pony Time" | Chubby Checker |
| March 6 | "Pony Time" | Chubby Checker |
| March 13 | "Pony Time" | Chubby Checker |
| March 20 | "Surrender" | Elvis Presley |
| March 27 | "Surrender" | Elvis Presley |
| April 3 | "Blue Moon" | The Marcels |
| April 10 | "Blue Moon" | The Marcels |
| April 17 | "Blue Moon" | The Marcels |
| April 24 | "Runaway" | Del Shannon |
| May 1 | "Runaway" | Del Shannon |
| May 8 | "Runaway" | Del Shannon |
| May 15 | "Runaway" | Del Shannon |
| May 22 | "Mother-in-Law" | Ernie K-Doe |
| May 29 | "Travelin' Man" | Ricky Nelson |