When Clark looks out of the window of his Metropolis apartment in Kansas, you can see fairly mountains in the background. Kansas is not known for its mountains.
Since when did Kansas have mountains and dense forests?
In a closeup of Clark's hand holding the silver talisman, the hand had a callus - how does invulnerable super-healing Clark get calluses?
At one point Tom Welling accidentally says "Bellevue" rather then "Belle Reve." (Close-captioning confirms the line should have mentioned "Belle Reve.")
Why is a blind Clark getting his books out of his locker and taking them to class? It's not like he can read them.
When Molly removes the hard drive from Chloe's computer, the screen near the computer goes blank. But in the shot before then, we can see that the computer isn't connected to anything.
Lana attacked Chloe with an axe and her punishment was just suspension? This was an assault with a deadly weapon on school grounds which is a criminal offence.
Clark says Molly was "recruited by MIT" - MIT doesn't recruit students.
When Clark, Chloe, and Lana were listening to the playback of the tape, you hear Lana say "Clark, it's happening" with the rain in the background. But when Lana said that, she was still inside the building.
Chloe mentions Clark's "baby blues". Traditionally, Superman does indeed have blue eyes; Tom Welling does not.
Only in Smallville would someone be able to use a cell phone in a hospital. They interfere with all the equipment.
What type of jail or prison allows visitors to vist the inmates at their cells?
Goofs and Nitpicks are courtesy of Tvtome.com.