Dr. Michaela Quinn-------------Jane Seymour
Byron Sully---------------------Joe Lando
Matthew Cooper----------------Chad Allen
Colleen Cooper------------------Erika Flores, seasons 1-3
Colleen Cooper Cook------------Jessica Bowman, seasons 3-6
Brian Cooper--------------------Shawn Toovey
Katie Sully----------------------Alexandra,McKenzie & Megan Calabrese
Loren Bray---------------------Orson Bean
Dorothy Jennings---------------Barbara Babcock
Jake Slicker---------------------Jim Knoblock
Hank Lawson------------------William Shockley
Robert E------------------------Henry G. Sanders
Grace---------------------------Jonelle Allen
Anthony------------------------Brenden Jefferson, season 4
Anthony------------------------Brandon Hammond, seasons 5 & 6
Horace Bing--------------------Frank Collison
Myra Bing----------------------Helen Udy
Samantha Bing----------------Holli Coleman
Rev. Timothy Johnson--------Geoffrey Lower
Ingrid---------------------------Jennifer Youngs
Preston A. Lodge III------------Jason Leland Adams
Dr. Andrew Cook----------------Brandon Douglas
Emma Morrison-----------------Charlotte Chatton
Teresa Morelas-----------------Michelle Bonilla, season 5
Teresa Morelas Slicker----------Alex Meneses, season 6
Daniel Simon--------------------John Schneider
Cloud Dancing-------------------Larry Sellers
Snow Bird-----------------------Tantoo Cardinal
Black Kettle---------------------Nick Rumas
Elizabeth Quinn-----------------Georgann Johnson
Rebecca Quinn------------------Elinor Donahue
Marjorie Quinn------------------Ally Mills
Charlotte Cooper----------------Diane Ladd
Emily Donavan------------------Heidi Kozak
Olive Bray Davis----------------Gail Strickland
General Custard----------------Jason Leland Adams
Sergeant O'Connor-------------Patrick Kilpatrick
Sergeant McKay----------------David Beecroft
Wolf-----------------------------Cody/Chaz

Want to know more about the characters? Take a look at the Character Insights.