Cocaine         

-          Snorting cocaine produces a slow onset of effects that can last from 15 to 30 minutes

-          smoking cocaine last from 5 to 10 minutes and produce a more intense high

-          Cocaine produces euphoric effects by building up dopamine in the brain, causing the continuous stimulation of neurons.

-          Users often feel euphoric, energetic, talkative, and mentally alert after taking small amounts of cocaine

-          Cocaine use can also temporarily lessen a user's need for food or sleep

-          Short-term physiological effects include constricted blood vessels, dilated pupils, and increased temperature, heart rate, and blood pressure.

-          Ingesting large amounts of cocaine can intensify the user's high, but can also lead to bizarre, erratic, and violent behavior.

-          Users who ingest large amounts may experience tremors, vertigo, muscle twitches, and paranoia.

-          Other possible effects of cocaine use include irritability, anxiety, and restlessness.

Heroin

-Heroin can be injected, smoked, or snorted.

-Intravenous injection produces the greatest intensity and most rapid onset of euphoria. Effects are felt in 7 to 8 seconds.

-sniffing or smoking develop more slowly, beginning in 10 to 15 minutes, sniffing or smoking heroin has increased in popularity because of the availability of high-purity heroin and the fear of sharing needles.

-After ingestion, heroin crosses the blood-brain barrier. While in the brain, heroin converts to morphine and binds rapidly to opioid receptors.

-Users tend to report feeling a “rush” or a surge of pleasurable sensations.

-The rush is usually accompanied by a warm flushing of the skin, dry mouth, and a heavy feeling in the user’s arms and legs.

-The user may also experience nausea, vomiting, and severe itching.

-Following the initial effects, the user will be drowsy for several hours with clouded mental function and slow cardiac function.

-Breathing is slowed, possibly to the point of death.

-Repeated heroin use produces tolerance and physical dependence.

-Withdrawal symptoms begin within a few hours of last use and can include restlessness, muscle and bone pain, insomnia, diarrhea, vomiting, cold flashes with goose bumps, and involuntary leg movements.

-These symptoms peak between 24 and 48 hours after the last dose and subside after about a week, but may persist for up to a month.

-can cause death to the fetus of a pregnant addict

Inhalants

-Heavy or sustained use of inhalants can cause tolerance and physical withdrawal symptoms within several hours to a few days after use. Withdrawal symptoms may include sweating, rapid pulse, hand tremors, insomnia, nausea, vomiting, physical agitation, anxiety, hallucinations, and grand mal seizures. Indicators of inhalant abuse include paint or stains on the body or clothing, spots or sores around the mouth, red or runny eyes and nose, chemical odor on the breath, a drunken or dazed appearance, loss of appetite, excitability, and/or irritability.