The vulcano of Nisyros is the most important attraction of the island.

The main town of the island of Nisyros is very picturesque. There are beautiful white washed houses and there are two castles: a Venetian fortress on the hill in the village and an old fort called Kastro. The latter fortress is situated at 1 kilometer distance inland and has walls of so called cylopean stones (very large) and an entrance that is made of blocks of lava rock. This is the site of the ancient Acropolis. Inside the walls there is not much more to see. You can reach the fort by taking the road that heads south from Mandraki.

The Venetian fortress that was built by the Knights of St. John after they conquered the island 1315, stands on a hill west of Mandraki. Next to the Venetian fortress is the Spiliani Panagia monastery that was built in 1600 around a cave. There are other monasteries on the island of Nisyros to be found, but the largest one is the monastery Panagia Spiliani.

Sometimes there are boat trips from Nisyros to the nearly island Giali / Yali, a small island with two hills and a beautiful beach, and sometimes there are boat trips to the beach on the tiny islet of San Antonio.

In the village of Loutra in the north of the island, not far from Mandraki there are hot springs which supposedly have a healing power against diseases such as arthritis and rheumatism. These hot springs originate directly from the vulcano. Other hot springs can be found in Avlaki, situated in the south of the island.