U.S. Federal Route 40 run east-west across Madison County. Most of this is on interstates. U.S. Rt. 40 passes through the following towns in Madison County. Highland
Troy Maryville Collinsville U.S. Rt. 40 is multi-plexed in Madison County. Interstate 70, from the Bond/Madison County Line to near Highland. Illinois State Route 143, at Highland.
A BGS on WB I-70/U.S. Rt. 40. EB U.S. Rt. 40/IL St Rt 143 near Highland. EB U.S. Rt. 40/IL St Rt 143; SB IL St Rt 160 at Highland. BGS on SB I-55/WB I-70. A set of BGS's on SB I-55/WB I-70. NB I-55; EB I-70/U.S. Rt. 40 in Collinsville. A junction marker on SB IL St Rt 159. A interesting bridge support on NB I-55; EB I-70/U.S. Rt. 40 near I-255 in Collinsville. NB I-55; EB I-70/U.S. Rt. 40 near Fairmont City.