since last Heparin dose,
Dose, mg/100 U of Heparin
Maximum dose of 50mg. Infusion rate of a 10-mg/mL solution should not
exceed 5 mg/min. Hypersensitivity reactions to protamine sulfate may
occur in patients with known hypersensitivity reactions to fish or those
previously exposed to protamine therapy or protamine-containing insulin.
Ref: Michelson, AD, Bovill, E, Monagle, P, Andrew,
M. Antithrombotic Therapy in Children. CHEST 1998; 114:748S-769S.