|
| |
Major
drugs used to treat Status Epilepticus
05 November 2004
|
|
Diazepam
|
Lorazepam
|
Fosphenytoin
|
Phenobarbital
|
|
Adult iv dose, mg/kg range
(total dose)
|
0.15-0.25
|
0.1 (4-8mg)
|
15-20
|
20
|
|
Pediatric iv dose, mg/kg range
(total dose)
|
|
|
|
|
|
Maximal administration rate,
mg/min
|
5
|
2
|
150
|
100
|
|
Time to stop status
|
1-3
|
6-10
|
10-30
|
20-30
|
|
Effective duration of action, hr
|
0.25-0.5
|
>12-24
|
24
|
>48
|
|
Elimination half-life, hr
|
30
|
14
|
24
|
100
|
|
Volume of distribution, L/kg
|
1-2
|
0.7-1.0
|
0.5-0.80
|
0.7
|
|
Potential side effects
|
|
|
|
|
|
Depression
of consciousness
|
10-30 min
|
Several Hours
|
None
|
Several days
|
|
Respiratory
depression
|
Occasional
|
Occasional
|
Infrequent
|
Occasional
|
|
Hypotension
|
Infrequent
|
Infrequent
|
Occasional
|
Infrequent
|
|
Cardiac
arrhythmias
|
-
|
-
|
In patients with CAD etc
|
Infrequent
|
|
