In London around the time of 1880 Drusilla met William, a sad, wimpy poet. She liked him and turned him into a vampire who was called Spike. They went to Prauge and was attacked by a mob. She was extremely weak but she had her new man, Spike, to take care of her. He took her to Sunnydale to find the blood of her sire, Angel, to make her strong again. She eventually regained her strength. She was strong again and at the end of season two she killed the slayer, Kendra. Spike took her and ran off. They went to South America where Dru ended up cheating on Spike with a chaos demon and leaving him for good. She shortly returns in season five, in hopes of getting back together with Spike, but doesnt't stay long, or with Spike.