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Zyban (Bupropion) is used to treat major depressive disorder and seasonal affective disorder. Do not take bupropion if you have taken a monoamine oxidase inhibitor (MAOI) such as isocarboxazid (Marplan), phenelzine (Nardil), rasagiline (Azilect), selegiline (Eldepryl), or tranylcypromine (Parnate) in the last 14 days If you have any of these conditions, you may not be able to use bupropion, or you may need a dosage adjustment or special tests during treatment At least one brand of bupropion (Zyban) is used to help people stop smoking by reducing cravings and other withdrawal effects, Bupropion is an antidepressant medication.