Immune System Pathway Identified To Fight Allergens, Asthma |
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Immune System Pathway Identified To Fight Allergens, Asthma![]() For first time, researchers from University of Pittsburgh School of Medicine have identified genetic components of dendritic cells that are key to asthma and allergy-related immune response malfunction. Targeting these elements could result in more effective drugs to treat allergic disorders and asthma, according to a study reported in May edition of the journal Nature Medicine. Dendritic cells are vital to immune response in that they recognize, capture and introduce threatening organisms to T lymphocytes-other immune cells that secrete potent proteins called cytokines that surround and destroy invaders. However, the Pittsburgh team's study goes further to illuminate a pathway that allergens use to act directly on dendritic cells to propel differentiation into T lymphocytes that fight back. " We now have identified a molecule, c-Kit, that's central to process of allergic response, " said Anuradha Ray, Ph. D. , co-corresponding author and professor of medicine and immunology in Division of Pulmonary, Allergy and Critical Care Medicine, University of Pittsburgh School of Medicine. " We show that genes encoding for c-Kit and cytokine interleukin 6 ( IL-6 ) are significantly activated when allergens are present, but c-Kit is very first molecule that gets triggered. " Interactions between viruses and bacteria and molecular steps that initiate the immune defense have remained largely unknown. Using cells cultured from c-Kit mutant mice, Doctor Ray, her husband and co-corresponding author Prabir Ray, Ph. D. , and their colleagues studied molecular reactions to assaults by cholera toxin and a standard allergen, house dust mites. In addition to c-Kit and IL-6, they found effects on stem cell factor and Jagged-2-immune system molecules that are parts of the activation process. " We've known T-cell side of the story for many years, and we know that dendritic cells are important, but what we did not know was how the dendritic cell does what it does, " said Doctor Prabir Ray. " Therapy directed against c-Kit specifically on dendritic cells using compounds coupled to c-Kit inhibitors such as Gleevec, a drug that is already FDA-approved and used in cancer treatment, may alleviate allergic diseases and, potentially, inflammatory bowel disease. " The Pittsburgh team incubated dendritic cells with cholera toxin and house dust mite allergens, finding that both substances induced significant secretion of c-Kit and IL-6, initial steps in a cascade resulting in activation of T helper cells. " Dual upregulation of c-Kit and stem cell factor has been noted in some cancers, such as small cell lung cancer. IL-6 has been associated with cancers such as multiple myeloma, " said Doctor Anuradha Ray. " Collectively, similar approaches to inhibit c-Kit, in addition to Gleevec or other inhibiting compounds could alleviate multiple cancers. " The University of Pittsburgh School of Medicine has filed a patent application regarding finding. This study makes up doctoral dissertation of first author Nandini Krishnamoorthy, a student in Immunology Graduate Program, and was conducted in laboratory of Doctor Prabir Ray, associate professor of medicine and immunology, University of Pittsburgh School of Medicine. In addition to Drs. Ray and Krishnamoorthy, authors are Timothy Oriss, Ph. D. , Melissa Paglia, B. S. , Mingjian Fei, M. S. , and Manohar Yarlagadda, M. S. , all of University of Pittsburgh School of Medicine; and Bart Vanhaesebroeck, Ph. D. , Queen Mary's School of Medicine and Dentistry, London. The study was funded by the National Heart, Lung, and Blood Institute and the National Institute of Allergy and Infectious Diseases at National Institutes of Health. University of Pittsburgh Medical Center See payment and shipping options and choose online pharmacy suit you the best |
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Botulism Risk from Canned Green Beans. FDA is warning consumers about potentially contaminated canned cut green beans manufactured by New Era Canning Company, New Era, Mich. New Era is voluntarily recalling the green beans because they may be contaminated with Clostridium botulinum (C. botulinum), the bacterium that causes botulism. Use Eye Cosmetics Safely. April is Women's Eye Health and Safety Month. Here are tips from FDA about storing, applying, wearing, and removing eye cosmetics. Food Label Helps Consumers Make Healthier Choices. The food label allows you to compare foods quickly and easily to choose the ones that best fit your dietary needs. Pet Food Products Seized at PETCO Distribution Center. Consumers who bought animal food products from PETCO in 16 states should take certain precautions Warning About Contaminated Pre-Filled Syringes. FDA has announced a nationwide recall of all lots of heparin and saline pre-filled flush syringes manufactured by AM2 PAT, Inc., of Angier, N.C. Consumers and health care facilities with any of the recalled syringes should stop using the product immediately |
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Immune System Pathway Identified To Fight Allergens, Asthma Understanding Strattera. Strattera with worldwide delivery Botulism Risk from Canned Green Beans. FDA is warning consumers about potentially contaminated canned cut green beans manufactured by New Era Canning Company, New Era, Mich. New Era is voluntarily recalling the green beans because they may be contaminated with Clostridium botulinum (C. botulinum), the bacterium that causes botulism. See payment and shipping options and choose online pharmacy suit you the best |