Fat distribution can influence a person's risk of disease. Fat carried around the waist and in the abdominal area, characterized by the "apple shape", is associated with an increased risk for many medical problems such as heart disease, cancer, high blood pressure, and diabetes. Fat that is mostly distributed around the buttocks and thighs is associated with a lower risk of developing these diseases. To achieve lasting weight loss, commitment must be given to making real changes in eating patterns. Individuals are who not committed will gain back their weight. Obesity is a chronic disease that affects many people and often requires long-term treatment to promote and sustain weight loss. As in other chronic conditions, such as diabetes or high blood pressure, long-term use of prescription medications may be appropriate for some individuals The medications most often used in the management of obesity are commonly known as "appetite suppressant" medications. Appetite suppressant medications promote weight loss by increasing metabolism and by decreasing appetite or increasing the feeling of being full. These medications work by increasing the serotonin and/or catecholamine - two brain chemicals that affect mood, appetite and metabolism. Over the short term, weight loss in obese individuals may reduce a number of health risks. Studies looking at the effects of appetite suppressant medication treatment on obesity-related health risks have found that some agents lower blood pressure, blood cholesterol, triglycerides (fats) and decrease insulin resistance (the body's inability to use blood sugar) over the short term. Long-term studies are currently being done to determine if weight loss from appetite suppressant medications can improve health.
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