Imiquimod 5% Cream for the Treatment of Actinic Keratoses
| Figure 1: Imiquimod stimulation of TLR-7 results in activation of IKK, which
phosphorylates IêB. Unphosphorylated IkB keeps NFkB inactive. ... http://www.skintherapyletter.com/2005/10.2/1.html |
Toll-Like Receptor-7 Modulates Immune Complex Glomerulonephritis ...
| C RNA (TLR3), imiquimod and RNA40 (TLR7), and CpG-ODN (TLR9). Consistent with
their respective TLR expression profile, mesangial cells produced the ... http://jasn.asnjournals.org/cgi/content/full/17/1/141 |
Expert Opinion - Expert Opinion on Therapeutic Targets - 10(1):69 ...
| Imiquimod exerts its antitumoural effect, at least in part, through agonistic
stimulation of TLR-7 and TLR-8 on dendritic cells, followed by NF-κB-dependent ... http://www.ashley-pub.com/doi/abs/10.1517/14728222.10.1.69 |
Combined TLR and CD40 Triggering Induces Potent CD8+ T Cell ...
| Similar to other TLR agonists, IRMs such as imiquimod, resiquimod (R-848), and
S-27609 (27609) induce a variety of cellular effects such as DC cytokine ... http://www.jem.org/cgi/content/full/199/6/775 |
UroToday - Conference Reports - Conference Reports
| CONCLUSIONS: These results demonstrate that the TLR-7 agonist, imiquimod, has
direct biologic activity against J82, T24, and TCC-SUP bladder cancer cell ... http://www.urotoday.com/prod/contents/confreport/article.asp?cat=confReport&sid=184&tid=398&aid=2671 |
| These observations extend the therapeutic spectrum of imiquimod to cutaneous
B-cell lymphomas and suggest the use of TLR-7/8 agonists in CLL immunotherapy. ... http://lib.bioinfo.pl/auth:Miller,RL |
Toll-Like Receptor (TLR) Antibodies: Monthly updates of Toll-Like ...
| Members of the Toll-Like Receptor (TLR) family, first discovered in Drosophila,
have been shown ... The immune response modifiers, imiquimod and resiquimod, ... http://www.ebioscience.com/ebioscience/whatsnew/tlr.htm |
LICR | News | Testing Different Vaccine Approaches To Defeat One ...
| Impact of Toll-like receptor (TLR)-7 ligand, imiquimod, on immune responses to
cancer antigens in vaccine recipients receiving Flt3-Ligand (FL) and peptide ... http://www.licr.org/C_news/archive.php/2003/06/02/testing-different-vaccine-approaches-to-defeat-one-disease/ |
| The TLR agonist kits represent convenient and economical tools to study the
stimulation ... TLR7 Agonist: Imiquimod (25 µg) - TLR8 Agonist: ssRNA40 (25 µg) ... http://www.invivogen.com/family.php?ID=140&ID_cat=2&ID_sscat=77 |
| Imiquimod exerts its antitumoural effect, at least in part, through agonistic
stimulation of TLR-7 and TLR-8 on dendritic cells, ... http://lib.bioinfo.pl/auth:Sch%C3%B6n,M |
Blackwell Synergy: J Cutan Pathol, Vol 32, Issue 4, pp. 257-262 ...
| Recently, it was discovered that imiquimod acts through the toll-like receptor (TLR)
7. We hypothesize that TLR7-signaling strongly induces the production ... http://www.blackwell-synergy.com/doi/abs/10.1111/j.0303-6987.2005.00297.x |
Journal of Drugs in Dermatology: Immunomodulators for skin cancer
| TLR-7 is an essential receptor for imiquimod-induced immune response (7).
Imiquimod also generates production of IFN-[gamma] after CD4 cells are stimulated ... http://www.findarticles.com/p/articles/mi_m0PDG/is_5_3/ai_n13457666 |
Toll-Like Receptor-7 Modulates Immune Complex Glomerulonephritis ...
| In vivo, a single injection of the TLR7 ligand imiquimod increased serum levels
... Different TLR expression profiles on immune cell subsets and nonimmune ... http://jasn.asnjournals.org/cgi/content/abstract/17/1/141 |
Immunology - There are two sides of the antitumoral activity of ...
| "Imiquimod exerts its antitumoral effect, at least in part, through binding to
TLR-7 and TLR-8 on dendritic cells followed by secretion of a multitude of... ... http://www.newsrx.com/issue_article/Pain-and-Central-Nervous-System-Week/2004-06-28/06282004333468W.html |
Methods and compositions related to irm compounds and toll-like ...
| Methods for identifying a compound that activates a TLR-mediated cellular ...
For example, the small molecule IRM imiquimod is useful for the treatment of ... http://www.freshpatents.com/Methods-and-compositions-related-to-irm-compounds-and-toll-like-receptor-pathways-dt20051103ptan20050245564.php |
Blackwell Synergy: Br J Dermatol, Vol 147, Issue 1, pp. 1-6 ...
| Imiquimod acts through TLR 7 and stimulates rapid synthesis and release of cytokines
... Imiquimod is the first small molecule disclosed to act through TLR ... http://www.blackwell-synergy.com/doi/abs/10.1046/j.1365-2133.2002.04945.x |
Project: Design, synthesis and application of molecularly defined ...
| Toll like receptors (TLR) bind small sized molecules generally derived from
microorganisms, ... The synthesis of CpG DNA and imiquimod molecules. ... http://www.onderzoekinformatie.nl/en/oi/nod/onderzoek/OND1301892/print |
Project: Design, synthesis and application of molecularly defined ...
| Key objectives are: understanding of TLR action, its effect on DC and exploitation
of this knowledge ... The synthesis of CpG DNA and imiquimod molecules. ... http://www.onderzoekinformatie.nl/en/oi/nod/onderzoek/OND1301892/ |
DermoTopics | Issue 2/2003 | 7th Annual Meeting of the Society for ...
| Imiquimod, approved for topical treatment of virus-induced papillomae in genital
regions is an antagonist for TLR-7 and TLR-8 present in dendritic cells. ... http://www.dermotopics.de/english/issue_2_03_e/7jahrestagung_2_2003_e.htm |
| Imiquimod is the first of the immune response modifiers to stimulate a localized
immune response to treat infectious skin conditions. The reported TLR-7 ... http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=12757252&dopt=Abstract |
news @ nature.com - From the analyst's couchTLR-targeted ...
| The most advanced TLR based therapeutic, 3M Pharmaceutical's imiquimod (Aldara),
is currently marketed for actinic keratosis, superficial basal cell ... http://www.nature.com/news/2005/051031/full/nrd1880.html |
Cancer Spectrum: Urosevic et al., pp. 1143-1153.
| Imiquimod directly activates innate immune effectors through a Toll-like
receptor (TLR) 7/MyD88-dependent pathway (13). Through the induction of the surface ... http://jncicancerspectrum.oxfordjournals.org/cgi/content/full/jnci;97/15/1143 |
| In marked contrast to responses to other TLR agonists, Dr. Levy has discovered that
... lipopolysaccharide, and imiquimod but preserves response to R-848. ... http://www.childrenshospital.org/cfapps/research/data_admin/Site364/mainpageS364P0.html |
From the Th1/Th2 Paradigm towards a Toll-Like Receptor/T-Helper ...
| Several drugs used successfully in the treatment of infections are potent TLR
agonists. Imiquimod is a strong TLR7 and TLR8 activator which induces IFN- ... http://aac.asm.org/cgi/content/full/49/10/3991 |
Focus on - Antibodies to TLR Family - Acris Antibodies
| The TLR family has significant homology in its cytoplasmic domain to the IL-1
receptor Type I. ... The immune response modifiers, imiquimod and resiquimod, ... http://www.acris-antibodies.com/focuson/focuson-new-004.html |
| Imiquimod exerts its antitumoral effect, at least in part, through binding to
TLR-7 and TLR-8 on dendritic cells followed by secretion of a multitude of ... http://www.ihop-net.org/UniPub/iHOP/gg/99334.html |
Selective Impairment of TLR-Mediated Innate Immunity in Human ...
| Such analysis was performed for each of the TLR ligands tested: tBLP, MALP, LPS,
imiquimod, and R-848. For all TLR ligands except R-848, adult plasma ... http://jimmunol.highwire.org/cgi/content/full/173/7/4627 |
| Nature.com (subscription), The most advanced TLR based therapeutic, 3M Pharmaceutical's
imiquimod (Aldara), is currently marketed for actinic keratosis, ... http://www.onconews.org/medications/imiquimod.html |
The TLR-7 agonist, imiquimod, enhances dendritic cell survival and ...
| The TLR-7 agonist, imiquimod, enhances dendritic cell survival and promotes tumor
antigen-specific T cell priming: relation to central nervous system ... http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16365406&dopt=Citation |
| InvivoGen strives to provide TLR ligands of the highest quality. ... RNA as well
as small synthetic molecules such as imiquimod and loxoribine. TLR9 Ligands ... http://www.invivogen.com/sscat.php?ID=9&ID_cat=2 |
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