CANNABIS and TOURETTE'S SYNDROME
If you've even watched a documentary on this sad condition, you can realize the drastic effect this disease has on those who cannot express themselves or improperly express themselves. This society is not big on compassion and seem not to realize that sometimes the person who needs a hug the most, appears to deserve it the least. The explosive sounds and cuss words that may come from the mouth of someone with Tourettes are uncontrollable but cannabis may make life easier for these sufferers. Kay Lee
Treatment of Tourette syndrome with delta-9-tetrahydrocannabinol (delta 9-THC): no influence on neuropsychological performance.
Muller-Vahl KR, Prevedel H, Theloe K, Kolbe H, Emrich HM, Schneider U.
Department of Clinical Psychiatry and Psychotherapy, Medical School Hannover, Hannover, Germany. firstname.lastname@example.org
Previous studies provide evidence that marijuana (Cannabis sativa) and delta-9-tetrahydrocannabinol (Delta(9)-THC), the major psychoactive ingredient of marijuana, respectively, are effective in the treatment of tics and behavioral problems in Tourette syndrome (TS).
It, therefore, has been speculated that the central cannabinoid receptor system might be involved in TS pathology. However, in healthy marijuana users there is an ongoing debate as to whether the use of cannabis causes acute and/or long-term cognitive deficits.
In this randomized double-blind placebo-controlled study, we investigated the effect of a treatment with up to 10 mg Delta(9)-THC over a 6-week period on neuropsychological performance in 24 patients suffering from TS. During medication and immediately as well as 5-6 weeks after withdrawal of Delta(9)-THC treatment, no detrimental effect was seen on learning curve, interference, recall and recognition of word lists, immediate visual memory span, and divided attention.
Measuring immediate verbal memory span, we even found a trend towards a significant improvement during and after treatment. Results from this study corroborate previous data suggesting that in patients suffering from TS, treatment with Delta(9)-THC causes neither acute nor long-term cognitive deficits.
Larger and longer-duration
controlled studies are recommended to provide more
information on the adverse effect profile of THC in
patients suffering from TS.
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