As much as 50 to 75 percent of obesity has genetic influences. Just what those genetic influences are that affect body weight have not been identified. During a binge, 10,000 to 20,000 calories can be consumed throughout the day. Binges usually consist of foods like cookies, candy, chips, ice cream and many other high calorie foods. Binges are often done in secret. After a binge, many of the feelings that caused the binge, like stress, may have subsided only to be replaced with feelings of guilt and lack of self-control. People respond differently to appetite suppressant medications, and some people experience more weight loss than others. Some obese patients using medication lose more than 10 percent of their starting body weight- an amount of weight loss that may reduce risk factors for obesity - related diseases, such as high blood pressure or diabetes. Most studies of appetite suppressant medications show that a patient's weight tends to level off after four to six months while still on medication treatment. While some patients and physicians may be concerned that this shows tolerance to the medications, the leveling off may mean that the medication has reached its limit of effectiveness. Based on the currently available studies, it is not clear if weight gain with continuing treatment is due to drug tolerance.
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