To be able penetrate to must have quickness and a number of different type crossover moves. Without it a good defender can stay in front of you not allowing you to drive to the basketball whether your purpose is to score a jumpshot or a layup.
The above image is just one of many ways to penetrate or drive towards the whole. Without another teammate to perform a screen for you, you will need quickness and a series of moves to fake out or go past your defender to create an open shot.