-Acts by neutralizing gastric acid and by increasing lower esophageal sphincter tone
-Used in treatment of PUD, GER, Stress ulcer prophylaxis
-All are best given 30 min - 2 hr postprandially and at hs
-All antacids can decrease absortion of H2-blockers, and interfere with effectiveness of sucralfate
-Mg-containing antacids have osmotic laxative effects
-Al-containing antacids are phosphate binders
PUD: 5 - 10 ml PO per dose pc and hs
Stress ulcer prophylaxis:
15 - 30 ml pNG/PO q1-4h for gastric pH < 4.5 (If pH < 3.5 dose is doubled)
Adverse effects:
Mg- diarrhea, Mg intoxication in CRF
Al- constipation, Al intoxication in CRF
Alginic acid - containing (Gaviscon)
-Forms a floating layer on gastric contents, acting as barrier to GER
-Alginic acid is not absorbed
-PUD: 15 - 30 ml PO pc and hs
-Stress ulcer prophylaxis: same as in Mg-Al antacids
